Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Amiya K. Ghosh"'
Autor:
Gisela G Slaats, Amiya K Ghosh, Lucas L Falke, Stéphanie Le Corre, Indra A Shaltiel, Glenn van de Hoek, Timothy D Klasson, Marijn F Stokman, Ive Logister, Marianne C Verhaar, Roel Goldschmeding, Tri Q Nguyen, Iain A Drummond, Friedhelm Hildebrandt, Rachel H Giles
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004594 (2014)
We recently reported that centrosomal protein 164 (CEP164) regulates both cilia and the DNA damage response in the autosomal recessive polycystic kidney disease nephronophthisis. Here we examine the functional role of CEP164 in nephronophthisis-relat
Externí odkaz:
https://doaj.org/article/8629e9b555ce48b0b8ca20f4fda80cc6
Publikováno v:
The Journals of Gerontology: Series A. 74:1709-1715
Visceral adipose tissue (VAT) inflammation plays a central role in longevity and multiple age-related disorders. Cellular senescence (SEN) is a fundamental aging mechanism that contributes to age-related chronic inflammation and organ dysfunction, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73b053abae954540f162ed6f7b3dd7c
https://doi.org/10.1093/gerona/gly290
https://doi.org/10.1093/gerona/gly290
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21379 (2011)
Genetic mutations are frequently associated with diverse phenotypic consequences, which limits the interpretation of the consequence of a variation in patients. Mutations in the retinitis pigmentosa 2 (RP2) gene are associated with X-linked RP, which
Externí odkaz:
https://doaj.org/article/c0b2f39bf3e749b4bd1b0ab27008ed2a
Publikováno v:
J Gerontol A Biol Sci Med Sci
The National Institute on Aging (NIA)-sponsored Interventions Testing Program (ITP) has identified a number of dietary drug interventions that significantly extend life span, including rapamycin, acarbose, and 17-α estradiol. However, these drugs ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af6aa7ab2d3121a709862155c33da82
https://pubmed.ncbi.nlm.nih.gov/31353414
https://pubmed.ncbi.nlm.nih.gov/31353414
Publikováno v:
Aging (Albany NY)
Adipose tissue dysfunction is associated with inflammation, metabolic syndrome and other diseases in aging. Recent work has demonstrated that compromised autophagy activity in aging adipose tissue promotes ER stress responses, contributing to adipose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fd0396066fefdea4b3f4efe1481cbeb
https://pubmed.ncbi.nlm.nih.gov/29695642
https://pubmed.ncbi.nlm.nih.gov/29695642
Autor:
Rannar Airik, Steve J. Elledge, Zhi Guo, Maddalena Castelli, Andreas Kispert, Simon Bekker-Jensen, Naheed W. Khan, Amiya K. Ghosh, Jens S. Andersen, Gisela G. Slaats, Toby W. Hurd, Alessandra Boletta, Jacob M. Schrøder, Friedhelm Hildebrandt, Anna Carina Weiss, Rachel H. Giles
Publikováno v:
Airik, R, Slaats, G G, Guo, Z, Weiss, A-C, Khan, N, Ghosh, A, Hurd, T W, Bekker-Jensen, S, Schrøder, J M, Elledge, S J, Andersen, J S, Kispert, A, Castelli, M, Boletta, A, Giles, R H & Hildebrandt, F 2014, ' Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling ', Journal of the American Society of Nephrology, vol. 25, no. 11, pp. 2573-2583 . https://doi.org/10.1681/ASN.2013050565
Nephronophthisis-related ciliopathies (NPHP-RCs) are developmental and degenerative kidney diseases that are frequently associated with extrarenal pathologies such as retinal degeneration, obesity, and intellectual disability. We recently identified
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c58042db34754a5a57a675cb32c270
https://doi.org/10.1681/asn.2013050565
https://doi.org/10.1681/asn.2013050565
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 70:1320-1329
Adipose tissue inflammation has been linked to age-related metabolic diseases. However, the underlying mechanisms are poorly understood. Adipose tissue inflammation and insulin resistance in diet associated obesity has been correlated with aberrant e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a091f182e70ce2d4fa0712ceac1d227
https://doi.org/10.1093/gerona/glu186
https://doi.org/10.1093/gerona/glu186
Autor:
Amiya K. Ghosh, Raymond Yung, Tomomi Toubai, Sanjay K. Garg, Ruma Banerjee, Colin Delaney, Pavan Reddy
Publikováno v:
Aging Cell
Regulatory T-cell (Treg, CD4(+) CD25(+)) dysfunction is suspected to play a key role in immune senescence and contributes to increased susceptibility to diseases with age by suppressing T-cell responses. FoxP3 is a master regulator of Treg function,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda7d237a26728f089af8d84f85c7d1c
http://europepmc.org/articles/PMC4032602
http://europepmc.org/articles/PMC4032602
Impaired autophagy activity is linked to elevated ER-stress and inflammation in aging adipose tissue
Publikováno v:
Aging (Albany NY)
Adipose tissue dysfunction in aging is associated with inflammation, metabolic syndrome and other diseases. We propose that impaired protein homeostasis due to compromised lysosomal degradation (micro-autophagy) might promote aberrant ER stress respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80abe1ca82cc22b50e3f8d9f5106366e
https://pubmed.ncbi.nlm.nih.gov/27777379
https://pubmed.ncbi.nlm.nih.gov/27777379
Autor:
Amiya K. Ghosh, Sreyashi Basu
Publikováno v:
Cancer Letters. 324:91-97
Tumor microenvironment contributes to a large extent for failure of immunological destruction of antigenic tumors. Most solid tumors adapt to the microenvironment and escape the host immune system. The dramatic and systemic effectiveness of neuro-imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300cb9f5674e6c4375d7d82cf96b0e39
https://doi.org/10.1016/j.canlet.2012.05.002
https://doi.org/10.1016/j.canlet.2012.05.002