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Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases

Autor: Gang Chen, Zuping Xia, Philip Lazarus, Amity Platt, Ying Liu

Publikováno v: Pharmacogenetics and Genomics. 26:370-380

Objective Exemestane (EXE) is a potent third-generation aromatase inhibitor used as endocrine therapy in breast cancer treatment and prevention. Characterization of its metabolic pathway is incomplete, with ambiguity existing in the identity of enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99aa73da0b2290ded97014bb7ac6ce40
https://doi.org/10.1097/fpc.0000000000000226

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The immunomodulatory, antitumor and antimetastatic responses of melanoma-bearing normal and alcoholic mice to sunitinib and ALT-803: a combinatorial treatment approach

Autor: Alexander A. Little, Zhaohui Zhu, Kiranjot K. Brar, Alisha A. McBride, Savanna R. Garcia, Amity Platt, Faya Zhang, Gary G. Meadows, Hui Zhang, Kari A. Gaither

Publikováno v: Cancer immunology, immunotherapy : CII. 65(9)

ALT-803, a novel IL-15/IL-15 receptor alpha complex, and the tyrosine kinase inhibitor, sunitinib, were examined for their single and combined effects on the growth of subcutaneous B16BL6 melanoma and on lymph node and lung metastasis. The study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa97893ee3a3dea025d17db13869c4e
https://pubmed.ncbi.nlm.nih.gov/27481107

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Abstract 1345: Antitumor and antimetastatic response of melanoma-bearing normal and alcoholic mice to Sunitinib and ALT-803 treatment

Autor: Kiran K. Brar, Kari A. Gaither, Savanna Castillo, Alisha A. McBride, Dung Luong, Amity Platt, Zhaohui Zhu, Alexander A. Little, Hui Zhang, Gary G. Meadows, Faya Zhang

Publikováno v: Cancer Research. 75:1345-1345

Chronic alcohol consumption (CAC) is a risk factor for melanoma as well as other cancers and can result in decreased patient survival. We previously showed that CAC increases the percentage of IFN-γ-producing CD8+ T cells exhibiting a memory phenoty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::874ee00ad8c7f8ca96fdb4626111aac7
https://doi.org/10.1158/1538-7445.am2015-1345

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Immune cell responses to combined treatment of murine melanoma with ALT-803 and Sunitinib in normal and chronic alcohol consuming mice (TUM2P.1032)

Autor: Alexander Little, Kari Gaither, Alisha McBride, Savanna Castillo, Kiran Brar, Amity Platt, Zhaohui Zhu, Faya Zhang, Dung Luong, Hui Zhang, Gary Meadows

Publikováno v: The Journal of Immunology. 194:69.29-69.29

The immune enhancing IL-15 super agonist ALT-803 and Sunitinib, a tyrosine kinase inhibitor that inhibits immunosuppressive myeloid derived suppressor cells (MDSC) and T regulatory (Treg) cells, were examined for their single and combined effects on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0f35855ef1d9544a67be64c7530eed43
https://doi.org/10.4049/jimmunol.194.supp.69.29

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