Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Amita Datta-Mannan"'
Autor:
Jing Liu, Karen Rowland‐Yeo, Almut Winterstein, Simon Dagenais, Qi Liu, Jeffrey S. Barrett, Rui Zhu, Cyrus Ghobadi, Amita Datta‐Mannan, Joy Hsu, Sujatha Menon, Mariam Ahmed, Pooja Manchandani, Paulien Ravenstijn
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 4, Pp n/a-n/a (2024)
Abstract Real‐world data (RWD) and real‐world evidence (RWE) are now being routinely used in epidemiology, clinical practice, and post‐approval regulatory decisions. Despite the increasing utility of the methodology and new regulatory guideline
Externí odkaz:
https://doaj.org/article/ef7db2fce839459fb90fcc8fc8bede48
Autor:
Amita Datta-Mannan, Hiuwan Choi, Zhaoyan Jin, Ling Liu, Jirong Lu, David J. Stokell, Anthony T. Murphy, Kenneth W. Dunn, Michelle M. Martinez, Yiqing Feng
Publikováno v:
PLoS ONE, Vol 19, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/88740c93e82b4e8cb5d7edb2fd408cba
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
A model-based framework is presented to predict monoclonal antibody (mAb) pharmacokinetics (PK) in humans based on in vitro measures of antibody physiochemical properties. A physiologically based pharmacokinetic (PBPK) model is used to explore the pr
Externí odkaz:
https://doaj.org/article/d38c4c49ffa248d5b8813a33df7d09fe
Autor:
Amita Datta-Mannan, Selina Estwick, Chen Zhou, Hiuwan Choi, Nicole E. Douglass, Derrick R. Witcher, Jirong Lu, Catherine Beidler, Rohn Millican
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Many therapeutic monoclonal antibodies (mAbs) were initially developed for intravenous (IV) administration. As a means to improve mAb drug-ability and the patient experience, subcutaneous (SC) administration is an increasingly important delivery rout
Externí odkaz:
https://doaj.org/article/58c5f4e8c8a14a51b74643d2b367cca2
Publikováno v:
Antibodies, Vol 11, Iss 1, p 2 (2021)
Bispecific antibodies (BsAb) that engage multiple pathways are a promising therapeutic strategy to improve and prolong the efficacy of biologics in complex diseases. In the early stages of discovery, BsAbs often exhibit a broad range of pharmacokinet
Externí odkaz:
https://doaj.org/article/f627a025c5d146a6ae4e14de99764155
Autor:
Donmienne Leung, Jacqueline M. Wurst, Tao Liu, Ruben M. Martinez, Amita Datta-Mannan, Yiqing Feng
Publikováno v:
Antibodies, Vol 9, Iss 1, p 2 (2020)
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past 30 years. Clinical success rates of antibodies have exceeded expectations, resulting in heavy investment in biologics discovery and development in addition to
Externí odkaz:
https://doaj.org/article/fdfc6332ec064146af9777409f73155a
Autor:
Amita Datta-Mannan, Bruce A. Molitoris, Yiqing Feng, Michelle M. Martinez, Ruben M. Sandoval, Robin M. Brown, Daniel Merkel, Johnny E. Croy, Kenneth W. Dunn
Publikováno v:
Drug Metabolism and Disposition. 51:403-412
Autor:
Huyen, Tran, Phenil J, Patel, Aktham, Aburub, Andrea, Sperry, Selina, Estwick, Mohamed E H, ElSayed, Amita Datta, -Mannan
Publikováno v:
Pharmaceutical Research. 39:2555-2567
Oral delivery of therapeutic peptides has been challenging due to multiple physiological factors and physicochemical properties of peptides. We report a systematic approach to identify formulation compositions combining a permeation enhancer and a pe
Publikováno v:
The AAPS Journal. 25
An integrated physiologically based modeling framework is presented for predicting pharmacokinetics and bioavailability of subcutaneously administered monoclonal antibodies in cynomolgus monkeys, based on in silico structure-derived metrics character
Publikováno v:
mAbs. 14
A model-based framework is presented to predict monoclonal antibody (mAb) pharmacokinetics (PK) in humans based on