Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Amita M. Chaudhari"'
Autor:
Octerloney B. McDonald, Carla A. Donatelli, William F. Huffman, Toshihiro Hamajima, Christine Thompson, Kelly E. Fisher, Martha A. Sarpong, Jamin C Wang, David Sutton, Dashyant Dhanak, Peter J. Tummino, Jun Tang, Ken A. Newlander, Zhihong V Lai, Hong Xiang, Kosuke Sasaki, Domingos J. Silva, Mary Ann Hardwicke, Jerry L. Adams, Cynthia A. Parrish, Schmidt Stanley J, Denis R. Patrick, Hiroko Nakamura, Jingsong Yang, Catherine A. Oleykowski, Robert A. Copeland, Amita M. Chaudhari, Ramona Plant, David H. Drewry, Kristin K Koretke-Brown, Nicholas D. Adams, Joelle Lorraine Burgess
Publikováno v:
Journal of Medicinal Chemistry. 53:3973-4001
The Aurora kinases play critical roles in the regulation of mitosis and are frequently overexpressed or amplified in human tumors. Selective inhibitors may provide a new therapy for the treatment of tumors with Aurora kinase amplification. Herein we
Autor:
William F. Huffman, Ken A. Newlander, Amita M. Chaudhari, Shu-Yun Zhang, Michael L. Moore, Jeffrey T. Finer, Kevin J. Duffy, Antony N. Shaw, Melody Diamond, David Sutton, Robert A. Copeland, Michael N. Zimmerman, Chiu-Mei M Sung, Leo F. Faucette, Roman Sakowicz, Jeffrey R. Jackson, Lusong Luo, Kurt R. Auger, Kenneth W. Wood, Jeffrey D. Carson, Carla A. Donatelli, Cynthia A. Parrish, Erin D. Hugger, Steven D. Knight, Lance Ridgers, Nicholas D. Adams, Joelle Lorraine Burgess, Dashyant Dhanak
Publikováno v:
Journal of Medicinal Chemistry. 50:4939-4952
Kinesin spindle protein (KSP), an ATPase responsible for spindle pole separation during mitosis that is present only in proliferating cells, has become a novel and attractive anticancer target with potential for reduced side effects compared to curre
Autor:
Duke M. Fitch, Stephen Schauer, Steven D. Knight, Zhengping Wang, Michael N. Zimmerman, Kurt R. Auger, Roman Sakowicz, Dashyant Dhanak, Han-Jie Zhou, Amita M. Chaudhari, Carrie E. Aroyan, Jeffrey T. Finer, Deping Chai, Jeffrey R. Jackson, Lance Ridgers, Luke W. Ashcraft, Seyed Ahmed, Kenneth Wood, Erin D. Hugger, Jennifer Kuo Chen Huang, Melchor V. Marin, John D. Elliott, Andrew Mcdonald, Cynthia A. Parrish, David Sutton, Ramesh Baliga, Mariela Colón, Lisa D. Belmont, Carla A. Donatelli, Nicholas D. Adams, Joelle Lorraine Burgess, Hong Jiang, Rosanna Tedesco, Bing Yao, Jianchao Wang, Kevin J. Duffy, Gustave Bergnes, Xiangping Qian, Chiu-Mei Sung, David J. Morgans, Robert A. Copeland, Bradley P. Morgan, Michael G. Darcy, Jeffrey D. Carson, Latesh Lad, Ken A. Newlander, Lusong Luo, Daniel W. Pierce, Schmidt Stanley J
Publikováno v:
ACS medicinal chemistry letters. 1(1)
Inhibition of mitotic kinesins represents a novel approach for the discovery of a new generation of anti-mitotic cancer chemotherapeutics. We report here the discovery of the first potent and selective inhibitor of centromere-associated protein E (CE
Autor:
Jeffrey R. Jackson, Latesh Lad, Ruth Lehr, Kurt R. Auger, Huizhen Zhao, Amita M. Chaudhari, Sharon Sweitzer, Jeffery D Carson, Neysa Nevins, Lusong Luo, Pearl S. Huang, Kenneth W. Wood, Valery Sudakin, Antony N. Shaw, Dashyant Dhanak, Dean E. McNulty, Cynthia A. Parrish, Roland S. Annan, Robert A. Copeland, Roman Sakowicz
Publikováno v:
Nature chemical biology. 3(11)
The mitotic kinesin KSP (kinesin spindle protein, or Eg5) has an essential role in centrosome separation and formation of the bipolar mitotic spindle. Its exclusive involvement in the mitotic spindle of proliferating cells presents an opportunity for
Autor:
Christine M. Gardiner, Martha A. Sarpong, Kaushik Raha, Ken A. Newlander, Kurt R. Auger, Steven D. Knight, Cynthia A. Parrish, Lance Ridgers, Glenn S. Van Aller, Carla A. Donatelli, Amita M. Chaudhari, Peter J. Tummino, Schmidt Stanley J, Chiu-Mei Sung, Eric Garver, Jeffrey D. Carson, Michael G. Darcy, Lusong Luo, Dashyant Dhanak, Nicholas D. Adams, Joelle Lorraine Burgess, Patricia A. Elkins, Melody Diamond
Publikováno v:
Molecular Cancer Therapeutics. 8:C62-C62
Phosphoinositide 3-kinase (PI3K) is a critical regulator of cell growth and transformation and its signaling pathway is one of the most commonly mutated pathways in human cancer. The mammalian target of rapamycin (mTOR), a class IV PI3K protein kinas
Autor:
Cynthia A. Parrish, Nicholas D. Adams, Kurt R. Auger, Joelle L. Burgess, Jeffrey D. Carson, Amita M. Chaudhari, Robert A. Copeland, Melody A. Diamond, Carla A. Donatelli, Kevin J. Duffy, Leo F. Faucette, Jeffrey T. Finer, William F. Huffman, Erin D. Hugger, Jeffrey R. Jackson, Steven D. Knight, Lusong Luo, Michael L. Moore, Ken A. Newlander, Lance H. Ridgers
Publikováno v:
Journal of Medicinal Chemistry; Oct2007, Vol. 50 Issue 20, p4939-4952, 14p