Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Amit U. Sinha"'
Autor:
Shiva Bamezai, Alex Jose Pulikkottil, Tribhuwan Yadav, Vegi Mahalakshmi Naidu, Julia Mueller, Jasmin Mark, Tamoghna Mandal, Kristin Anja Feder, Susann Lehle, Chenlin Song, Reinhild Rosler, Sebastian Wiese, Jessica I Hoell, Andreas Kloetgen, Aly Karsan, Ankita Kumari, Luke Wojenski, Amit U Sinha, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Elisa Donato, Andreas Trumpp, Elisabeth Kruse, Stephan Hamperl, Lee Zou, Vijay P. S. Rawat, Christian Buske
Publikováno v:
Blood Journal.
RNA-binding proteins (RBPs) form a large and diverse class of factors many members of which are overexpressed in hematological malignancies. RBPs participate in various processes of mRNA metabolism and prevent harmful DNA:RNA hybrids or R-loops. Here
Autor:
Margaret A. Shipp, Jeffery L. Kutok, Scott A. Armstrong, Gabriel A. Rabinovich, Amit U. Sinha, Joerg Faber, Andrei Krivtsov, Anna Gaworczyk, Tomasz Szczepanski, Katarzyna Mycko, Wojciech Mlynarski, Kunihiko Takeyama, Evan O'Donnell, Jing Ouyang, Scott J. Rodig, Przemyslaw Juszczynski
Supplementary Data from MLL-Rearranged B Lymphoblastic Leukemias Selectively Express the Immunoregulatory Carbohydrate-Binding Protein Galectin-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad99e6af497ac2f9755535027d554f26
https://doi.org/10.1158/1078-0432.22442699
https://doi.org/10.1158/1078-0432.22442699
Autor:
Margaret A. Shipp, Jeffery L. Kutok, Scott A. Armstrong, Gabriel A. Rabinovich, Amit U. Sinha, Joerg Faber, Andrei Krivtsov, Anna Gaworczyk, Tomasz Szczepanski, Katarzyna Mycko, Wojciech Mlynarski, Kunihiko Takeyama, Evan O'Donnell, Jing Ouyang, Scott J. Rodig, Przemyslaw Juszczynski
Purpose: Patients with mixed lineage leukemia (MLL)–rearranged B-lymphoblastic leukemias (B-ALL) have an unfavorable prognosis and require intensified treatment. Multiple MLL fusion partners have been identified, complicating the diagnostic evaluat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e21d7e989cd49aebae75083d29432c
https://doi.org/10.1158/1078-0432.c.6519368
https://doi.org/10.1158/1078-0432.c.6519368
Autor:
Bärbel Edelmann-Stephan, Andreas Hochhaus, Sabine Brandt, Nicolas Schröder, Florian Perner, Gurumoorthy Krishnamoorthy, Iain Coldham, Amit U. Sinha, Claudia Waskow, Lars Bullinger, Stefanie Jilg, Philipp J. Jost, Martin Ungelenk, Francesca Palandri, Matthias Mann, Rebecca Austin, Frank Edlich, Tina M. Schnöder, Susann Rahmig, Carolin Herzog, Robert Zeiser, Steven W. Lane, Arno Meiler, Thomas Ernst, Christian A. Hübner, Juliane Mohr, Ashok Kumar Jayavelu, Peter R. Mertens, Nicolas Huber, Florian H. Heidel, Ann Mullally, Berend Isermann
Publikováno v:
Nature
Janus kinases (JAKs) mediate responses to cytokines, hormones and growth factors in haematopoietic cells1,2. The JAK gene JAK2 is frequently mutated in the ageing haematopoietic system3,4 and in haematopoietic cancers5. JAK2 mutations constitutively
Autor:
Hong Wen, Anagha Deshpande, Tatiana G. Kutateladze, Sujita Khanal, Mohamad Zandian, Amit U. Sinha, Xiaobing Shi, Pan Zhang, Michael G. Poirier, Brianna J. Klein, Stefan K. Bohlander, Karina Barbosa, Fan Xuan, Yi Zhang, Aniruddha J. Deshpande, Khan L. Cox, Qiong Tong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Chromosomal translocations of the AF10 (or MLLT10) gene are frequently found in acute leukemias. Here, we show that the PZP domain of AF10 (AF10PZP), which is consistently impaired or deleted in leukemogenic AF10 translocations, plays a critical role
Autor:
Vijay P.S. Rawat, Alex Jose Pulikkottil, Leticia Quintanilla-Martinez, Naidu M. Vegi, Ursula Kohlhofer, Shiva Bamezai, Tobias Ammer, Amit U. Sinha, Christian Buske, Fabian Mohr, Kristin Feder, Tamoghna Mandal
Publikováno v:
Leukemia. 36(2)
Acute myeloid leukemia (AML) is considered a poor prognosis malignancy where patients exhibit altered glucose metabolism and stem cell signatures that contribute to AML growth and maintenance. Here, we report that the epigenetic factor, Ten-Eleven Tr
Autor:
Irene Gonzalez-Menendez, Paola Caiafa, Lüder-Hinrich Meyer, Fabian Mohr, Vijay P.S. Rawat, Tobias Herold, Deniz Demir, Leticia Quintanilla-Fend, Geertruy te Kronnie, Alex Jose Pulikkottil, Shiva Bamezai, Fabio Ciccarone, Hartmut Döhner, Maria Götze, Michaela Feuring-Buske, Christian Buske, Irmela Jeremias, Elena Fischbein, Klaus-Michael Debatin, Amit U. Sinha, Chiara Borga, Konstanze Döhner
Publikováno v:
Leukemia 35, 389–403 (2020)
Leukemia
Leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer characterized by skewed epigenetic patterns, raising the possibility of therapeutically targeting epigenetic factors in this disease. Here we report that among differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05765430d5571d4c155eb9fa10d4f63b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59126
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=59126
Autor:
Amit U Sinha, Scott A Armstrong
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31690 (2012)
Increasing use of high throughput genomic scale assays requires effective visualization and analysis techniques to facilitate data interpretation. Moreover, existing tools often require programming skills, which discourages bench scientists from exam
Externí odkaz:
https://doaj.org/article/f178e080ebb64e998d407adcb2825737
Autor:
Michael F. Berger, Nikolaus Schultz, Alessandro Pastore, Ronald C. Hendrickson, Qing X. Li, Kinisha Gala, Francisco Sanchez-Vega, Pedram Razavi, Sarat Chandarlapaty, Madeline Dorso, Amit U. Sinha, Young Rock Chung, Omar Abdel-Wahab, James J. Hsieh
Publikováno v:
Oncogene
Estrogen receptor alpha (ERα) is a ligand-activated nuclear receptor that directs proliferation and differentiation in selected cancer cell types including mammary-derived carcinomas. These master-regulatory functions of ERα require trans-acting el
Autor:
Amit U. Sinha, Stefanie G Ames, Maddie Chrisman, Meg Stanger, Ericka L. Fink, Devin Corboy, Lauren J Alessi
Publikováno v:
Pediatric Quality & Safety
Supplemental Digital Content is available in the text.
Introduction: Critical illness results in physical impairments which may be mitigated by intensive care unit (ICU)-based early mobility. This initiative aimed to develop and implement ICU-ba
Introduction: Critical illness results in physical impairments which may be mitigated by intensive care unit (ICU)-based early mobility. This initiative aimed to develop and implement ICU-ba