Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amit Sarswat"'
Autor:
Angelica M. Bello, Amit Sarswat, Andrew V. Caprariello, Chithra M. Muthuramu, Lakshmi P. Kotra, Sai Kumar Chakka, Ewa Wasilewski, Shannon E. Dunn, Peter K. Stys
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2643-2656
Protein arginine deiminases (PAD) are implicated in a variety of inflammatory and neurodegenerative diseases including multiple sclerosis (MS). Following the discovery of an in silico hit containing hydantoin and a piperidine moiety, we hypothesized
Autor:
Lalit Kumar, Veenu Bala, Amit Sarswat, Karthik Nandikonda, Santosh Jangir, Nand Lal, Vishnu L. Sharma
Publikováno v:
Journal of Heterocyclic Chemistry. 52:156-162
A green and facile synthesis of dithiocarbamate derivatives containing disulfide linkage by the ring opening reaction of trithiocarbonate with amines under solvent and catalyst-free condition with excellent yields is being reported. Environmental ben
Autor:
Pratiksha Singh, Gopal Gupta, Veenu Bala, Vishnu L. Sharma, Nand Lal, Amit Sarswat, Santosh Jangir, Praveen K. Shukla, Bhavana Kushwaha, Lokesh Kumar, Jagdamba P. Maikhuri, Lalit Kumar
Publikováno v:
Org. Biomol. Chem.. 12:3090-3099
1-Substituted piperazinecarbodithioates were obtained by an unusual removal of CS2 in benzyl substituted dithiocarbamate derivatives under acid and basic conditions during design and synthesis of 1,4-(disubstituted)piperazinedicarbodithioates as doub
Autor:
Vishnu L. Sharma, Mohammad Imran Siddiqi, Praveen K. Shukla, Sanjay Krishna, Amit Sarswat, Tara Rawat, Gopal Gupta, Dhanaraju Mandalapu, Atindra K. Pandey, Veenu Bala, Jagdamba P. Maikhuri, Santosh Jangir, Lokesh Kumar, Ashish Jain, Bhavana Kushwaha, Nand Lal, Lalit Kumar
Publikováno v:
European journal of medicinal chemistry. 115
Trichomoniasis and candidiasis are amongst the most common morbidity-causing reproductive tract infections, generally treated by Metronidazole and Fluconazole respectively. Poor vaginal efficacy, drug-resistance and non-spermicidal nature limit their
Publikováno v:
Organic Letters. 13:2330-2333
A facile synthesis of S-(2-thioxo-1,3-dithiolan-4-yl)methyl dialkylcarbamothioates (3) and S-thiiran-2-ylmethyl dialkylcarbamothioate (5) has been reported by the reaction of 5-(chloromethyl)-1,3-oxathiolane-2-thione (1) with sodium dialkylcarbamodit
Autor:
Vikas Verma, Diwakar Dalela, Jagdamba P. Maikhuri, Vishnu L. Sharma, Rajeev Kumar, Ashish Jain, Rajeev K. Jain, Amit Sarswat, Gopal Gupta
Publikováno v:
Investigational New Drugs. 30:582-593
The existing drugs for benign prostatic hyperplasia (BPH) are partially effective with undesirable side-effects; hence new agents acting by different mechanism(s) are required as supplements. Modulation of estrogen receptor signaling using selective
Autor:
Gopal Gupta, Rajeev Kumar, Ashish Jain, Yenamandra S. Prabhakar, Vikas Verma, Kirti, Jagdamba P. Maikhuri, Lalit Kumar, Smriti Sharma, Diwakar Dalela, Jawahar Lal, Vishnu L. Sharma, Amit Sarswat, Pandey Shailendra Kumar, Nand Lal
Publikováno v:
Journal of Medicinal Chemistry. 54:302-311
A series of 27 aryl/heteroaryl/aralkyl/aroyl piperazines were synthesized, and most of these compounds reduced prostate weight of mature rats by 15-47%. Three compounds, 10, 12, and 18, had better activity profile (reduced prostate weight by 47%, 43%
Autor:
Karthik Nandikonda, Veenu Bala, Vishnu L. Sharma, Santosh Jangir, Nand Lal, Lalit Kumar, Amit Sarswat
Publikováno v:
ChemInform. 46
A green and facile synthesis of dithiocarbamate derivatives containing disulfide linkage by the ring opening reaction of trithiocarbonate with amines under solvent and catalyst-free condition with excellent yields is being reported. Environmental ben
Autor:
Vikas Sharma, Vikas Verma, Vishnu L. Sharma, Vishal Singh, Jagdamba P. Maikhuri, Gopal Gupta, Amit Sarswat, Rajeev Kumar, Ashish Jain
Publikováno v:
Toxicology and applied pharmacology. 283(3)
Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activi
Autor:
Amit Kumar, Vishnu L. Sharma, Vikas Verma, Veenu Bala, Vikas Sharma, Jagdamba P. Maikhuri, Amit Sarswat, Gopal Gupta, Nand Lal, Lalit Kumar, Karan Singh Saini, Hamidullah, Santosh Jangir, Rituraj Konwar
Publikováno v:
European journal of medicinal chemistry. 85
A new series of 2-(alkoxy(hydroxy)phosphoryloxy)ethyl dialkylcarbodithioate derivatives was synthesized and evaluated against endocrine related cancers, acting via modulation of Akt-pathway. Eighteen compounds were active at 7.24–100 μM against MD