Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Amit Sarswat"'
Autor:
Angelica M. Bello, Amit Sarswat, Andrew V. Caprariello, Chithra M. Muthuramu, Lakshmi P. Kotra, Sai Kumar Chakka, Ewa Wasilewski, Shannon E. Dunn, Peter K. Stys
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:2643-2656
Protein arginine deiminases (PAD) are implicated in a variety of inflammatory and neurodegenerative diseases including multiple sclerosis (MS). Following the discovery of an in silico hit containing hydantoin and a piperidine moiety, we hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956c87f1213d1dffc54c5b327fc1a494
https://doi.org/10.1016/j.bmc.2017.03.006
https://doi.org/10.1016/j.bmc.2017.03.006
Autor:
Lalit Kumar, Veenu Bala, Amit Sarswat, Karthik Nandikonda, Santosh Jangir, Nand Lal, Vishnu L. Sharma
Publikováno v:
Journal of Heterocyclic Chemistry. 52:156-162
A green and facile synthesis of dithiocarbamate derivatives containing disulfide linkage by the ring opening reaction of trithiocarbonate with amines under solvent and catalyst-free condition with excellent yields is being reported. Environmental ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8e0d22567f1e7a7ff093d2121c4067
https://doi.org/10.1002/jhet.1995
https://doi.org/10.1002/jhet.1995
Autor:
Pratiksha Singh, Gopal Gupta, Veenu Bala, Vishnu L. Sharma, Nand Lal, Amit Sarswat, Santosh Jangir, Praveen K. Shukla, Bhavana Kushwaha, Lokesh Kumar, Jagdamba P. Maikhuri, Lalit Kumar
Publikováno v:
Org. Biomol. Chem.. 12:3090-3099
1-Substituted piperazinecarbodithioates were obtained by an unusual removal of CS2 in benzyl substituted dithiocarbamate derivatives under acid and basic conditions during design and synthesis of 1,4-(disubstituted)piperazinedicarbodithioates as doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36cc27fc6b53e0bd62d16a41e6f276fd
https://doi.org/10.1039/c4ob00005f
https://doi.org/10.1039/c4ob00005f
Autor:
Vishnu L. Sharma, Mohammad Imran Siddiqi, Praveen K. Shukla, Sanjay Krishna, Amit Sarswat, Tara Rawat, Gopal Gupta, Dhanaraju Mandalapu, Atindra K. Pandey, Veenu Bala, Jagdamba P. Maikhuri, Santosh Jangir, Lokesh Kumar, Ashish Jain, Bhavana Kushwaha, Nand Lal, Lalit Kumar
Publikováno v:
European journal of medicinal chemistry. 115
Trichomoniasis and candidiasis are amongst the most common morbidity-causing reproductive tract infections, generally treated by Metronidazole and Fluconazole respectively. Poor vaginal efficacy, drug-resistance and non-spermicidal nature limit their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec6075838eed043e1f06efd5cbe7e76
https://pubmed.ncbi.nlm.nih.gov/27084496
https://pubmed.ncbi.nlm.nih.gov/27084496
Publikováno v:
Organic Letters. 13:2330-2333
A facile synthesis of S-(2-thioxo-1,3-dithiolan-4-yl)methyl dialkylcarbamothioates (3) and S-thiiran-2-ylmethyl dialkylcarbamothioate (5) has been reported by the reaction of 5-(chloromethyl)-1,3-oxathiolane-2-thione (1) with sodium dialkylcarbamodit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec1eab63c5cdbdc90572753a64a78eb
https://doi.org/10.1021/ol2005825
https://doi.org/10.1021/ol2005825
Autor:
Vikas Verma, Diwakar Dalela, Jagdamba P. Maikhuri, Vishnu L. Sharma, Rajeev Kumar, Ashish Jain, Rajeev K. Jain, Amit Sarswat, Gopal Gupta
Publikováno v:
Investigational New Drugs. 30:582-593
The existing drugs for benign prostatic hyperplasia (BPH) are partially effective with undesirable side-effects; hence new agents acting by different mechanism(s) are required as supplements. Modulation of estrogen receptor signaling using selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a88d8ddc36da3bead2b5f6a6449acc
https://doi.org/10.1007/s10637-010-9620-2
https://doi.org/10.1007/s10637-010-9620-2
Autor:
Gopal Gupta, Rajeev Kumar, Ashish Jain, Yenamandra S. Prabhakar, Vikas Verma, Kirti, Jagdamba P. Maikhuri, Lalit Kumar, Smriti Sharma, Diwakar Dalela, Jawahar Lal, Vishnu L. Sharma, Amit Sarswat, Pandey Shailendra Kumar, Nand Lal
Publikováno v:
Journal of Medicinal Chemistry. 54:302-311
A series of 27 aryl/heteroaryl/aralkyl/aroyl piperazines were synthesized, and most of these compounds reduced prostate weight of mature rats by 15-47%. Three compounds, 10, 12, and 18, had better activity profile (reduced prostate weight by 47%, 43%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33a841d3c1c999658ec7a83da2eef34
https://doi.org/10.1021/jm101163m
https://doi.org/10.1021/jm101163m
Autor:
Karthik Nandikonda, Veenu Bala, Vishnu L. Sharma, Santosh Jangir, Nand Lal, Lalit Kumar, Amit Sarswat
Publikováno v:
ChemInform. 46
A green and facile synthesis of dithiocarbamate derivatives containing disulfide linkage by the ring opening reaction of trithiocarbonate with amines under solvent and catalyst-free condition with excellent yields is being reported. Environmental ben
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3900ae48f516b57de051454a504d4655
https://doi.org/10.1002/chin.201524074
https://doi.org/10.1002/chin.201524074
Autor:
Vikas Sharma, Vikas Verma, Vishnu L. Sharma, Vishal Singh, Jagdamba P. Maikhuri, Gopal Gupta, Amit Sarswat, Rajeev Kumar, Ashish Jain
Publikováno v:
Toxicology and applied pharmacology. 283(3)
Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53181b6c759216188fe7e003f06e28c
https://pubmed.ncbi.nlm.nih.gov/25655200
https://pubmed.ncbi.nlm.nih.gov/25655200
Autor:
Amit Kumar, Vishnu L. Sharma, Vikas Verma, Veenu Bala, Vikas Sharma, Jagdamba P. Maikhuri, Amit Sarswat, Gopal Gupta, Nand Lal, Lalit Kumar, Karan Singh Saini, Hamidullah, Santosh Jangir, Rituraj Konwar
Publikováno v:
European journal of medicinal chemistry. 85
A new series of 2-(alkoxy(hydroxy)phosphoryloxy)ethyl dialkylcarbodithioate derivatives was synthesized and evaluated against endocrine related cancers, acting via modulation of Akt-pathway. Eighteen compounds were active at 7.24–100 μM against MD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f8693e4c4cef967ae2d83f430f577c
https://pubmed.ncbi.nlm.nih.gov/25128666
https://pubmed.ncbi.nlm.nih.gov/25128666