Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amit R. Ashtekar"'
Autor:
Robert P. Richter, Amit R. Ashtekar, Lei Zheng, Danielle Pretorius, Tripathi Kaushlendra, Ralph D. Sanderson, Amit Gaggar, Jillian R. Richter
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Angiopoietin-2 (Ang-2) is a key mediator of vascular disease during sepsis, and elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical outcomes. We have previously observed that biomarkers of endothelial glycocalyx
Externí odkaz:
https://doaj.org/article/09c6efd531964cad857260ed54088102
Autor:
Jan O. Jansen, Amit R. Ashtekar, Robert P. Richter, Jeffrey D. Kerby, Jillian R. Richter, Lei Zheng, Shannon C Walker
Publikováno v:
Shock
INTRODUCTION Acute traumatic coagulopathy (ATC) is an endogenous impairment in hemostasis that often contributes to early mortality after trauma. Endothelial glycocalyx damage is associated with trauma-induced coagulation abnormalities; however, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97103d3f99eab44b6cc7f339de108d2c
https://doi.org/10.1097/shk.0000000000001867
https://doi.org/10.1097/shk.0000000000001867
Autor:
Jeffrey D. Kerby, Shannon C Walker, Amit R. Ashtekar, Lindy M Reynolds, Lei Zheng, Robert P. Richter, Jan O. Jansen, Rindi Uhlich, Jillian R. Richter, Parker J. Hu, Alyssa A Kirkman, Russell Griffin
Publikováno v:
Shock. 54:703-709
Traumatic injury and hemorrhagic shock result in endothelial cell activation and vascular dysfunction that, if not corrected, can propagate multiorgan failure. Angiopoietin-1 and angiopoietin-2 are important regulators of endothelial cell function, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d2984ccf40f2e947cb228ede1cc5a6
https://doi.org/10.1097/shk.0000000000001597
https://doi.org/10.1097/shk.0000000000001597
Autor:
Jillian R. Richter, Amit R. Ashtekar, Robert P. Richter, Jean-Francois Pittet, Shannon C Walker, Lei Zheng
Publikováno v:
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 21(9)
OBJECTIVES Results from preclinical and adult sepsis studies suggest that the balance of circulating angiopoietin-1 and -2 levels, represented as angiopoietin-2/-1 ratios, plays a pivotal role in mediating vascular dysfunction and organ injury during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589941d1e5b6caddc9e5388d040b8509
https://pubmed.ncbi.nlm.nih.gov/32740186
https://pubmed.ncbi.nlm.nih.gov/32740186
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50460 (2012)
Francisella tularensis (FT) is a highly virulent pathogen for humans and other mammals. Severe morbidity and mortality is associated with respiratory FT infection and there are concerns about intentional dissemination of this organism. Therefore, FT
Externí odkaz:
https://doaj.org/article/989bd4358ced40e3a32cf21db61c7789
Autor:
Joaquín Zúñiga, Francesca Polverino, Amit Rout, Caroline A. Owen, Xiaoyun Wang, Ilyas Yambayev, Luis Jiménez, Amit R. Ashtekar, Joselyn Rojas-Quintero, Carmen Hernandez, Kevin S. Harrod, Jennifer L. Tipper, Gustavo A. Ramírez, Patrick R. Burkett
Publikováno v:
JCI Insight. 3
Matrix metalloproteinase-9 (MMP-9) cleaves various proteins to regulate inflammatory and injury responses. However, MMP-9's activities during influenza A viral (IAV) infections are incompletely understood. Herein, plasma MMP-9 levels were increased i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7a2087ad78811ac5209bab65081503
https://doi.org/10.1172/jci.insight.99022
https://doi.org/10.1172/jci.insight.99022
Autor:
Amit R. Ashtekar, Jennifer L. Tipper, John E. Trombley, Jeffrey D. Brand, A. Timothy Adewale, Ren-Jay Shei, Ahmed Lazrak, Kevin S. Harrod, Zhihong Yu, Steven M. Rowe, Sadis Matalon
Publikováno v:
JCI Insight. 3
Severe influenza (IAV) infection can develop into bronchopneumonia and edema, leading to acquired respiratory distress syndrome (ARDS) and pathophysiology. Underlying causes for pulmonary edema and aberrant fluid regulation largely remain unknown, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5c70067aa65a0bd0016a110ffcb4c3b
https://doi.org/10.1172/jci.insight.123467
https://doi.org/10.1172/jci.insight.123467
Autor:
Bhaskar Saha, Amit R. Ashtekar
Publikováno v:
Trends in Immunology. 24:485-490
Polymorphonuclear neutrophils (PMNs), comprising about two-thirds of peripheral blood leukocytes, are absent from uninfected, uninjured, ‘healthy' tissues. PMNs, proposed to be terminally differentiated and transcriptionally inactive, are the first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc246fc9bd3694256bfd9e82bdd5eff4
https://doi.org/10.1016/s1471-4906(03)00235-7
https://doi.org/10.1016/s1471-4906(03)00235-7
Autor:
Suzanne M. Michalek, Dalia E. Gaddis, Amit R. Ashtekar, Qingan Xu, Ping Zhang, J. Katz, Mingwen Fan
A Salmonella vector vaccine expressing the saliva-binding region (SBR) of the adhesin AgI/II of Streptococcus mutans has been shown to induce a mixed Th1/Th2 anti-SBR immune response in mice and to require Toll-like receptor 2 (TLR2), TLR4, and MyD88
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d1d277a3d81d8d6a31f9b14fa3f8d9
https://europepmc.org/articles/PMC3165457/
https://europepmc.org/articles/PMC3165457/
Autor:
Ping Zhang, Amit R. Ashtekar, Stefanie N. Vogel, Prasad Rallabhandi, Champion Deivanayagam, Suzanne M. Michalek, Jannet Katz
Francisella tularensis is the causative agent of tularemia, a severe, debilitating disease of humans and other mammals. As this microorganism is also classified as a “category-A pathogen” and a potential biowarfare agent, there is a need for an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d84fbb3d8a933c1f4ec9c031b19683
https://europepmc.org/articles/PMC2614597/
https://europepmc.org/articles/PMC2614597/