Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Amit Jairaman"'
Autor:
Hamza Atcha, Amit Jairaman, Jesse R. Holt, Vijaykumar S. Meli, Raji R. Nagalla, Praveen Krishna Veerasubramanian, Kyle T. Brumm, Huy E. Lim, Shivashankar Othy, Michael D. Cahalan, Medha M. Pathak, Wendy F. Liu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Macrophages perform diverse functions during immune responses, but the molecular mechanisms by which physical properties of the tissue regulate macrophage behavior remain unknown. Here the authors find that Piezo1 is a mechanosensor of stiffness, and
Externí odkaz:
https://doaj.org/article/30c02e56c3ed471195876b3588e37e70
Autor:
Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/d74b2e4cb1a84ae98fd95f8389c0a7c0
Autor:
Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H. Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G. Aleph Prieto, Leslie M. Thompson, Joan S. Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jones
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Abstract The discovery of TREM2 as a myeloid-specific Alzheimer’s disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions
Externí odkaz:
https://doaj.org/article/2fc5155c4b834bdf97f0aa5db0218942
Autor:
Amit Jairaman, Amanda McQuade, Alberto Granzotto, You Jung Kang, Jean Paul Chadarevian, Sunil Gandhi, Ian Parker, Ian Smith, Hansang Cho, Stefano L Sensi, Shivashankar Othy, Mathew Blurton-Jones, Michael D Cahalan
Publikováno v:
eLife, Vol 11 (2022)
The membrane protein TREM2 (Triggering Receptor Expressed on Myeloid cells 2) regulates key microglial functions including phagocytosis and chemotaxis. Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD
Externí odkaz:
https://doaj.org/article/69b87460172149e083d3a847b9a787f6
Autor:
Amit Jairaman, Michael Cahalan
Publikováno v:
Bio-Protocol, Vol 11, Iss 19 (2021)
Elevations in cytosolic calcium (Ca2+) drive a wide array of immune cell functions, including cytokine production, gene expression, and cell motility. Live-cell imaging of cells loaded with ratiometric chemical Ca2+ indicators remains the gold standa
Externí odkaz:
https://doaj.org/article/43230d702a0e4ac190888bda39222c3f
Autor:
Tobias X Dong, Shivashankar Othy, Milton L Greenberg, Amit Jairaman, Chijioke Akunwafo, Sabrina Leverrier, Ying Yu, Ian Parker, Joseph L Dynes, Michael D Cahalan
Publikováno v:
eLife, Vol 6 (2017)
Ca2+ influx through Orai1 channels is crucial for several T cell functions, but a role in regulating basal cellular motility has not been described. Here, we show that inhibition of Orai1 channel activity increases average cell velocities by reducing
Externí odkaz:
https://doaj.org/article/c43576b4857b402ca2edd7c7540ca0b0
Autor:
Tobias X Dong, Shivashankar Othy, Amit Jairaman, Jonathan Skupsky, Angel Zavala, Ian Parker, Joseph L Dynes, Michael D Cahalan
Publikováno v:
eLife, Vol 6 (2017)
Calcium is an essential cellular messenger that regulates numerous functions in living organisms. Here, we describe development and characterization of ‘Salsa6f’, a fusion of GCaMP6f and tdTomato optimized for cell tracking while monitoring cytos
Externí odkaz:
https://doaj.org/article/9b0f397a22cd45589cafd282c3004bf4
Autor:
Christel Claes, Whitney E. England, Emma P. Danhash, Sepideh Kiani Shabestari, Amit Jairaman, Jean Paul Chadarevian, Jonathan Hasselmann, Andy P. Tsai, Morgan A. Coburn, Jessica Sanchez, Tau En Lim, Jorge L. S. Hidalgo, Christina Tu, Michael D. Cahalan, Bruce T. Lamb, Gary E. Landreth, Robert C. Spitale, Mathew Blurton‐Jones, Hayk Davtyan
Publikováno v:
Alzheimer's & Dementia. 18:1765-1778
The P522R variant of PLCG2, expressed by microglia, is associated with reduced risk of Alzheimer's disease (AD). Yet, the impact of this protective mutation on microglial responses to AD pathology remains unknown. Chimeric AD and wild-type mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463825c6c305b25a2f0c80da82f03755
https://doi.org/10.1002/alz.12577
https://doi.org/10.1002/alz.12577
Autor:
Timothy S. Kountz, Murali Prakriya, Kenneth A. Stauderman, Candace D Kountz, Amit Jairaman, Robert P. Schleimer
Publikováno v:
The Journal of Immunology. 207:1275-1287
The airway epithelial cells (AECs) lining the conducting passageways of the lung secrete a variety of immunomodulatory factors. Among these, PGE2 limits lung inflammation and promotes bronchodilation. By contrast, IL-6 drives intense airway inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6bf41eddbb94452d0bb2a5796040a862
https://doi.org/10.4049/jimmunol.2100127
https://doi.org/10.4049/jimmunol.2100127
Autor:
Hamza Atcha, Medha M. Pathak, Michael D. Cahalan, Wendy Liu, Amit Jairaman, Elizabeth L. Evans
Publikováno v:
Curr Opin Solid State Mater Sci
The immune system performs critical functions to defend against invading pathogens and maintain tissue homeostasis. Immune cells reside within or are recruited to a host of mechanically active tissues throughout the body and, as a result, are exposed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdb93a8ae0561bab44275bed51abb99
https://pubmed.ncbi.nlm.nih.gov/35645593
https://pubmed.ncbi.nlm.nih.gov/35645593