Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Amit Gaggar"'
Autor:
Teodora Nicola, Nancy Wenger, Xin Xu, Michael Evans, Luhua Qiao, Gabriel Rezonzew, Youfeng Yang, Tamas Jilling, Camilla Margaroli, Kristopher Genschmer, Kent Willis, Namasivayam Ambalavanan, J. Edwin Blalock, Amit Gaggar, Charitharth Vivek Lal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Bronchopulmonary dysplasia (BPD) is a chronic lung disease of prematurity. Exposure to noxious stimuli such as hyperoxia, volutrauma, and infection in infancy can have long-reaching impacts on lung health and predispose towards the developme
Externí odkaz:
https://doaj.org/article/194ba58ce72542aaab48a844418a8020
Autor:
Kyle T. Mincham, Samia Akthar, Dhiren F. Patel, Garance F. Meyer, Clare M. Lloyd, Amit Gaggar, James E. Blalock, Robert J. Snelgrove
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114630- (2024)
Summary: Leukotriene A4 hydrolase (LTA4H) is a bifunctional enzyme, with dual activities critical in defining the scale of tissue inflammation and pathology. LTA4H classically operates intracellularly, primarily within myeloid cells, to generate pro-
Externí odkaz:
https://doaj.org/article/6caf61c0a2154fe5a0c686927b68274e
Autor:
Nirmal S. Sharma, Kapil Patel, Ezgi Sari, Shruti Shankar, Maria G. Gastanadui, Diego Moncada-Giraldo, Yixel Soto-Vazquez, Delores Stacks, Louise Hecker, Kevin Dsouza, Mudassir Banday, Edward O’Neill, Paul Benson, Gregory Payne, Camilla Margaroli, Amit Gaggar
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 16 (2023)
Externí odkaz:
https://doaj.org/article/b8cd25c16b7d406fb31b8898b8183d5a
Autor:
Michael John Patton, Carlos J. Orihuela, Kevin S. Harrod, Mohammad A. N. Bhuiyan, Paari Dominic, Christopher G. Kevil, Daniel Fort, Vincent X. Liu, Maha Farhat, Jonathan L. Koff, Charitharth V. Lal, Anuj Gaggar, Robert P. Richter, Nathaniel Erdmann, Matthew Might, Amit Gaggar
Publikováno v:
Critical Care, Vol 27, Iss 1, Pp 1-12 (2023)
Abstract Background Recent single-center reports have suggested that community-acquired bacteremic co-infection in the context of Coronavirus disease 2019 (COVID-19) may be an important driver of mortality; however, these reports have not been valida
Externí odkaz:
https://doaj.org/article/08100dfe0b7b44c1ad101bf1bafeb813
Autor:
Nancy M. Wenger, Luhua Qiao, Teodora Nicola, Zoha Nizami, Isaac Martin, Brian A. Halloran, Kosuke Tanaka, Michael Evans, Xin Xu, Timothy G. Dinan, Charles Kakilla, Gillian DunnGalvin, Namasivayam Ambalavanan, Kent A. Willis, Amit Gaggar, Charitharth Vivek Lal
Publikováno v:
Frontiers in Nutrition, Vol 10 (2023)
IntroductionDysbiosis of the gut microbiome may augment lung disease via the gut-lung axis. Proteobacteria may contribute to tissue proteolysis followed by neutrophil recruitment, lung tissue injury, and perpetuation of chronic inflammation. To study
Externí odkaz:
https://doaj.org/article/d74b1c86a43c49bba760c2f43a762a1b
Autor:
Camilla Margaroli, Timothy Fram, Nirmal S. Sharma, Siddharth B. Patel, Jennifer Tipper, Sarah W. Robison, Derek W. Russell, Seth D. Fortmann, Mudassir M. Banday, Yixel Soto-Vazquez, Tarek Abdalla, Sawanan Saitornuang, Matthew C. Madison, Sixto M. Leal Jr., Kevin S. Harrod, Nathaniel B. Erdmann, Amit Gaggar
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Neutrophilic inflammation characterizes several respiratory viral infections, including COVID-19–related acute respiratory distress syndrome, although its contribution to disease pathogenesis remains poorly understood. Blood and airway immune cells
Externí odkaz:
https://doaj.org/article/99e6187f08e34f4d83544380537612d3
Autor:
Camilla Margaroli, Paul Benson, Maria G. Gastanadui, Chunyan Song, Liliana Viera, Dongqi Xing, J. Michael Wells, Rakesh Patel, Amit Gaggar, Gregory A. Payne
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
ObjectivesOur objective was to examine coronary endothelial and myocardial programming in patients with severe COVID-19 utilizing digital spatial transcriptomics.BackgroundSevere acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has well-establis
Externí odkaz:
https://doaj.org/article/52d9d920acea47819c808732d70ce744
Autor:
Robert P. Richter, Amit R. Ashtekar, Lei Zheng, Danielle Pretorius, Tripathi Kaushlendra, Ralph D. Sanderson, Amit Gaggar, Jillian R. Richter
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Angiopoietin-2 (Ang-2) is a key mediator of vascular disease during sepsis, and elevated plasma levels of Ang-2 are associated with organ injury scores and poor clinical outcomes. We have previously observed that biomarkers of endothelial glycocalyx
Externí odkaz:
https://doaj.org/article/09c6efd531964cad857260ed54088102
Autor:
Robert P. Richter, Gregory A. Payne, Namasivayam Ambalavanan, Amit Gaggar, Jillian R. Richter
Publikováno v:
Matrix Biology Plus, Vol 14, Iss , Pp 100106- (2022)
The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function throu
Externí odkaz:
https://doaj.org/article/1aeae2cd1a314c989f7309dc5a7429f6
Autor:
Amelia Freeman, Luhua Qiao, Nelida Olave, Gabriel Rezonzew, Samuel Gentle, Brian Halloran, Gloria S. Pryhuber, Amit Gaggar, Trent E. Tipple, Namasivayam Ambalavanan, Charitharth Vivek Lal
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants with Bronchopulmonary
Externí odkaz:
https://doaj.org/article/a77a493e93a84952b8f9d5217a92c176