Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Amit C. Vas"'
Autor:
Katherine L Furniss, Hung-Ji Tsai, Jo Ann W Byl, Andrew B Lane, Amit C Vas, Wei-Shan Hsu, Neil Osheroff, Duncan J Clarke
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003832 (2013)
By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes. In humans, the strand passage reaction of DNA topoisomerase II (Topo II) is the target of s
Externí odkaz:
https://doaj.org/article/925baffde6b44627b6f84bc643f95894
Autor:
Duncan J. Clarke, Amit C. Vas
Publikováno v:
Cell Cycle. 7:293-296
The Aurora kinases comprise a family of evolutionary conserved serine/threonine kinases that have important functions in centrosome duplication, mitotic spindle assembly, chromosome condensation, chromosome biorientation on the spindle and chromosome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456c661f8e94cd620c57333b90fffea3
https://doi.org/10.4161/cc.7.3.5381
https://doi.org/10.4161/cc.7.3.5381
Autor:
Duncan J. Clarke, Juan F. Giménez-Abián, Catherine A. Andrews, Laura A. Díaz-Martínez, Amit C. Vas
Publikováno v:
Cell Cycle. 5:1925-1928
Checkpoint controls confer order to the cell cycle and help prevent genome instability. Here we discuss the Topoisomerase II (Decatenation) Checkpoint which functions to regulate mitotic progression so that chromosomes can be efficiently condensed in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88130ed3d0adb53292bd1677b74c489
https://doi.org/10.4161/cc.5.17.3200
https://doi.org/10.4161/cc.5.17.3200
Publikováno v:
Molecular and Cellular Biology. 21:5767-5777
Cdc2 kinase is a master regulator of cell cycle progression in the fission yeast Schizosaccharomyces pombe. Our data indicate that Cdc2 phosphorylates replication factor Orp2, a subunit of the origin recognition complex (ORC). Cdc2 phosphorylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6102acbb2ed0dbdf9af4c493d71fdd4e
https://doi.org/10.1128/mcb.21.17.5767-5777.2001
https://doi.org/10.1128/mcb.21.17.5767-5777.2001
Autor:
Vincent Guacci, Amit C. Vas, Duncan J. Clarke, Catherine A. Andrews, Juan F. Giménez-Abián, Laura A. Díaz-Martínez
Publikováno v:
Cell Cycle. 4:1555-1557
The spindle assembly checkpoint monitors biorientation of chromosomes on the metaphase spindle and inhibits the Anaphase Promoting Complex (APC) specificity factor Cdc20. If APC-Cdc20 is the sole target of the spindle checkpoint, then cells lacking A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bd1b4745baea4159a4940f7c55a463
https://doi.org/10.4161/cc.4.11.2144
https://doi.org/10.4161/cc.4.11.2144
Autor:
Amit C. Vas, Janet Leatherwood
Publikováno v:
Cell Cycle. 2:572-574
Considerable evidence connects heterochromatin or silenced chromatin with the Origin Recognition Complex (ORC) which is needed for initiation of DNA replication.1-7 In this review we consider biological forces that might be served by this connection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7718fa5e7d82905db85f7878010b4a3a
https://doi.org/10.4161/cc.2.6.578
https://doi.org/10.4161/cc.2.6.578
Autor:
Wei Shan Hsu, Hung-Ji Tsai, Duncan J. Clarke, Catherine A. Andrews, Stacy L. Erickson, Amit C. Vas
Genome stability depends on faithful chromosome segregation, which relies on maintenance of chromatid cohesion during S phase. In eukaryotes, Pds1/securin is the only known inhibitor that can prevent loss of cohesion. However, pds1Δ yeast cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f72d87e98999e4dab5a51cfae06f85b
https://europepmc.org/articles/PMC3133416/
https://europepmc.org/articles/PMC3133416/
Publikováno v:
Methods in Molecular Biology ISBN: 9781607613398
Topoisomerase II activity is crucial to maintain genome stability through the removal of catenanes in the DNA formed during DNA replication and scaffolding the mitotic chromosome. Perturbed Topo II activity causes defects in chromosome segregation du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84febc40b901362af62ed7d5a5a5774b
https://doi.org/10.1007/978-1-60761-340-4_14
https://doi.org/10.1007/978-1-60761-340-4_14
Publikováno v:
Molecular biology of the cell. 18(2)
Although chromosome condensation in the yeast Saccharomyces cerevisiae has been widely studied, visualization of this process in vivo has not been achieved. Using Lac operator sequences integrated at two loci on the right arm of chromosome IV and a L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef61e0031077d41600e806e3eb288344
https://pubmed.ncbi.nlm.nih.gov/17151360
https://pubmed.ncbi.nlm.nih.gov/17151360
Autor:
Julie Green, Juan F. Giménez-Abián, Amit C. Vas, Brian Meier, Wei-Shan Hsu, Stacy L. Erickson, Krystyn E. VanderWaal, Duncan J. Clarke, Catherine A. Andrews, Laura A. Díaz-Martínez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Topoisomerase II (Topo II) performs topological modifications on double-stranded DNA molecules that are essential for chromosome condensation, resolution, and segregation. In mammals, G2 and metaphase cell cycle delays induced by Topo II poisons have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8e509c48136e27acdf4209610c5895
http://hdl.handle.net/10261/96635
http://hdl.handle.net/10261/96635