Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Amit Berson"'
Autor:
Amit Berson, Lindsey D. Goodman, Ashley N. Sartoris, Charlton G. Otte, James A. Aykit, Virginia M.-Y. Lee, John Q. Trojanowski, Nancy M. Bonini
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-10 (2019)
Abstract RNA-binding proteins (RBPs) are associated with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), but the underlying disease mechanisms remain unclear. In an unbiased screen in Drosophila for RBPs that genetically intera
Externí odkaz:
https://doaj.org/article/a8dbde8e1b534815af67340eabe6e702
Autor:
Chia-Yu Chung, Amit Berson, Jason R. Kennerdell, Ashley Sartoris, Travis Unger, Sílvia Porta, Hyung-Jun Kim, Edwin R. Smith, Ali Shilatifard, Vivianna Van Deerlin, Virginia M.-Y. Lee, Alice Chen-Plotkin, Nancy M. Bonini
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
TDP-43 is associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTD-TDP). Here, the authors identify the transcriptional elongation factor Ell as a strong modifier of TDP-43-mediated
Externí odkaz:
https://doaj.org/article/b2c2979de7ba485791653b7eba03aec1
Autor:
Chia-Yu Chung, Amit Berson, Jason R. Kennerdell, Ashley Sartoris, Travis Unger, Sílvia Porta, Hyung-Jun Kim, Edwin R. Smith, Ali Shilatifard, Vivianna Van Deerlin, Virginia M. -Y. Lee, Alice Chen-Plotkin, Nancy M. Bonini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)
The original version of this Article contained an error in the author affiliations. The affiliation of Alice Chen-Plotkin with the Department of Neurology, Perelman School of Medicine, Philadelphia, PA, 19104 USA was inadvertently omitted. This has n
Externí odkaz:
https://doaj.org/article/047b45b259744e7ca73ab2b6088f0b28
Autor:
Amit Berson, Shahar Barbash, Galit Shaltiel, Yael Goll, Geula Hanin, David S. Greenberg, Maya Ketzef, Albert J Becker, Alon Friedman, Hermona Soreq
Publikováno v:
EMBO Molecular Medicine, Vol 4, Iss 8, Pp 730-742 (2012)
Abstract Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such errors and the underlying mechanism in sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired
Externí odkaz:
https://doaj.org/article/49e7e34d894b4d9c9423564b115be40a
Autor:
Amit Berson, Hermona Soreq
Publikováno v:
Rambam Maimonides Medical Journal, Vol 1, Iss 2, p e0014 (2010)
In Alzheimer’s disease (AD), premature demise of acetylcholine-producing neurons and the consequent decline of cholinergic transmission associate with the prominent cognitive impairments of affected individuals. However, the enzymatic activities of
Externí odkaz:
https://doaj.org/article/ff4042c32e974eda92c7faea4278fe5e
Autor:
Debra Toiber, Amit Berson, David Greenberg, Naomi Melamed-Book, Sophia Diamant, Hermona Soreq
Publikováno v:
PLoS ONE, Vol 3, Iss 9, p e3108 (2008)
BackgroundAlzheimer's disease (AD) involves loss of cholinergic neurons and Tau protein hyper-phosphorylation. Here, we report that overexpression of an N-terminally extended "synaptic" acetylcholinesterase variant, N-AChE-S is causally involved in b
Externí odkaz:
https://doaj.org/article/2018499a57c049bf8580dad94ba61bb7
Autor:
Lindsey D. Goodman, Mercedes Prudencio, Nicholas J. Kramer, Luis F. Martinez-Ramirez, Ananth R. Srinivasan, Matthews Lan, Michael J. Parisi, Yongqing Zhu, Jeannie Chew, Casey N. Cook, Amit Berson, Aaron D. Gitler, Leonard Petrucelli, Nancy M. Bonini
Publikováno v:
Nature Neuroscience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7602096e29136da8f37cfc01affd94
https://doi.org/10.1038/s41593-023-01274-y
https://doi.org/10.1038/s41593-023-01274-y
Autor:
Nancy M. Bonini, Greg Donahue, Shelley L. Berger, Li-San Wang, Benjamin A. Garcia, Alexandre Amlie-Wolf, Amit Berson, Raffaella Nativio, Xiaolong Cui, John Q. Trojanowski, Oksana Shcherbakova, Ananth R. Srinivasan, Ji Nie, Simone Sidoli, Chuan He, Yemin Lan
Publikováno v:
Nature genetics
Nat Genet
Nat Genet
Protein aggregation is the hallmark of neurodegeneration, but the molecular mechanisms underlying late-onset Alzheimer's disease (AD) are unclear. Here we integrated transcriptomic, proteomic and epigenomic analyses of postmortem human brains to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2383ce0a4b9c74eec67c32e7bbf41e12
http://europepmc.org/articles/PMC8098004
http://europepmc.org/articles/PMC8098004
Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD
Autor:
Casey Cook, Michael Parisi, Luis F. Martinez-Ramirez, Ananth R. Srinivasan, Nicholas J. Kramer, Nancy M. Bonini, Jeannie Chew, Amit Berson, Aaron D. Gitler, Yongqing Zhu, Matthews Lan, Mercedes Prudencio, Lindsey D. Goodman, Leonard Petrucelli
Publikováno v:
Nature neuroscience
An expanded GGGGCC hexanucleotide of more than 30 repeats (termed (G4C2)30+) within C9orf72 is the most prominent mutation in familial frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS) (termed C9+). Through an unbiased large-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38d770f243bd7acdd7da6f181ec35a4
http://europepmc.org/articles/PMC6535128
http://europepmc.org/articles/PMC6535128
Autor:
Alexandre Amlie-Wolf, Amit Berson, Sager J. Gosai, F. Brad Johnson, Yemin Lan, Jon B. Toledo, Greg Donahue, Nancy M. Bonini, Ferit Tuzer, Claudio Torres, John Q. Trojanowski, Li-San Wang, Shelley L. Berger, Raffaella Nativio, Brian D. Gregory
Publikováno v:
Nature Neuroscience. 21:497-505
Aging is the strongest risk factor for Alzheimer’s disease (AD), although the underlying mechanisms remain unclear. The chromatin state, in particular through the mark H4K16ac, has been implicated in aging and thus may play a pivotal role in age-as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339124c304f57be19a3aae365dbca80b
https://doi.org/10.1038/s41593-018-0101-9
https://doi.org/10.1038/s41593-018-0101-9