Zobrazeno 1 - 10
of 486
pro vyhledávání: '"Amit Bar‐Or"'
Autor:
Ali I. Mirza, Feng Zhu, Natalie Knox, Lucinda J. Black, Alison Daly, Christine Bonner, Gary Van Domselaar, Charles N. Bernstein, Ruth Ann Marrie, Janace Hart, E. Ann Yeh, Amit Bar-Or, Julia O’Mahony, Yinshan Zhao, William Hsiao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-10 (2024)
Abstract Background The interplay between diet and the gut microbiota in multiple sclerosis (MS) is poorly understood. We aimed to assess the interrelationship between diet, the gut microbiota, and MS. Methods We conducted a case-control study includ
Externí odkaz:
https://doaj.org/article/db0251094e334aea88de44e1bc83d86a
Autor:
Tobias Derfuss, Robert Bermel, Chien-Ju Lin, Stephen L. Hauser, Ludwig Kappos, Timothy Vollmer, Giancarlo Comi, Gavin Giovannoni, Hans-Peter Hartung, Martin S. Weber, Jianmei Wang, Nikki Jessop, Cathy Chognot, Licinio Craveiro, Amit Bar-Or
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 17 (2024)
Background: Patients with multiple sclerosis (PwMS) have an increased risk of infections. Objectives: To characterize incidence, clinical characteristics, outcomes and risk factors of infections, and serious infections (SIs) in ocrelizumab (OCR)-trea
Externí odkaz:
https://doaj.org/article/aed1889aa6044652a518886ae29cb31b
A cross‐sectional study of MRI features and the gut microbiome in pediatric‐onset multiple sclerosis
Autor:
Feng Zhu, Yinshan Zhao, Douglas L. Arnold, Amit Bar‐Or, Charles N. Bernstein, Christine Bonner, Morag Graham, Janace Hart, Natalie Knox, Ruth Ann Marrie, Ali I. Mirza, Julia O'Mahony, Gary Van Domselaar, E. Ann Yeh, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett, US Network of Pediatric MS Centers, the Canadian Pediatric Demyelinating Disease Network
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 2, Pp 486-496 (2024)
Abstract Objective To identify gut microbiome features associated with MRI lesion burden in persons with pediatric‐onset multiple sclerosis (symptom onset 0.08). At the phylum level, high Tenericutes (relative abundance) was associated with higher
Externí odkaz:
https://doaj.org/article/c3b87d3d518943ee9ec32de4a16ca75c
Autor:
Vinicius A. Schoeps, Xiaoyuan Zhou, Mary K. Horton, Feng Zhu, Kathryn E. McCauley, Zahra Nasr, Akash Virupakshaiah, Mark P. Gorman, Leslie A. Benson, Bianca Weinstock‐Guttman, Amy Waldman, Brenda L. Banwell, Amit Bar‐Or, Ruth Ann Marrie, Gary vanDomselaar, Julia O'Mahony, Ali I. Mirza, Charles N. Bernstein, E. Ann Yeh, T. Charles Casper, Susan V. Lynch, Helen Tremlett, Sergio Baranzini, Emmanuelle Waubant, the US Network of Pediatric MS Centers
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 1, Pp 169-184 (2024)
Abstract Objective The relationship between multiple sclerosis and the gut microbiome has been supported by animal models in which commensal microbes are required for the development of experimental autoimmune encephalomyelitis. However, observationa
Externí odkaz:
https://doaj.org/article/c9e43b903a07463299bbc4354d77e079
Autor:
Bruce A. C. Cree, Rachel Maddux, Amit Bar‐Or, Hans‐Peter Hartung, Amandeep Kaur, Elizabeth Brown, Yicong Li, Yanhua Hu, James K. Sheffield, Diego Silva, Sarah Harris
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 10, Pp 1725-1737 (2023)
Abstract Objective To investigate the serologic response, predictors of response, and clinical outcomes associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) vaccination and infection in ozanimod‐treated participants with
Externí odkaz:
https://doaj.org/article/4a8aee4d3b7d474b98f18866748e3647
Autor:
Stephen L. Hauser, Ludwig Kappos, Amit Bar-Or, Heinz Wiendl, David Paling, Mitzi Williams, Ralf Gold, Andrew Chan, Ron Milo, Ayan Das Gupta, Goeril Karlsson, Roseanne Sullivan, Gordon Graham, Martin Merschhemke, Dieter A. Häring, Patrick Vermersch
Publikováno v:
Neurology and Therapy, Vol 12, Iss 5, Pp 1491-1515 (2023)
Abstract The importance of B cells in multiple sclerosis (MS) has been demonstrated through the advent of B-cell-depleting anti-CD20 antibody therapies. Ofatumumab is the first fully human anti-CD20 monoclonal antibody (mAb) developed and tested for
Externí odkaz:
https://doaj.org/article/eebd67c7598744dda6a94266f7a71dd5
Autor:
Hans-Peter Hartung, Bruce A.C. Cree, Michael Barnett, Sven G. Meuth, Amit Bar-Or, Lawrence Steinman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Disease-modifying therapies for relapsing multiple sclerosis reduce relapse rates by suppressing peripheral immune cells but have limited efficacy in progressive forms of the disease where cells in the central nervous system play a critical role. To
Externí odkaz:
https://doaj.org/article/87bfd7c2d3e74112b55c030c71ee445b
Autor:
Hanane Touil, Rui Li, Leah Zuroff, Craig S. Moore, Luke Healy, Francesca Cignarella, Laura Piccio, Samuel Ludwin, Alexandre Prat, Jennifer Gommerman, Frederick C. Bennett, Dina Jacobs, Joyce A. Benjamins, Robert P. Lisak, Jack P. Antel, Amit Bar-Or
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104789- (2023)
Summary: Background: B cells can be enriched within meningeal immune-cell aggregates of multiple sclerosis (MS) patients, adjacent to subpial cortical demyelinating lesions now recognized as important contributors to progressive disease. This subpial
Externí odkaz:
https://doaj.org/article/7c524e1075d448d58fba5b49832be3e8
Autor:
Amit Bar-Or, Gian-Andrea Thanei, Christopher Harp, Corrado Bernasconi, Ulrike Bonati, Anne H. Cross, Saloumeh Fischer, Laura Gaetano, Stephen L. Hauser, Robert Hendricks, Ludwig Kappos, Jens Kuhle, David Leppert, Fabian Model, Annette Sauter, Harold Koendgen, Xiaoming Jia, Ann E. Herman
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104662- (2023)
Summary: Background: Neurofilament light chain (NfL), a neuronal cytoskeletal protein that is released upon neuroaxonal injury, is associated with multiple sclerosis (MS) relapsing activity and has demonstrated some prognostic ability for future rela
Externí odkaz:
https://doaj.org/article/e7ff9f024a2e4966833fd5346456e54f
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
B cells within secondary lymphoid tissues encompass a diversity of activation states and multiple maturation processes that reflect antigen recognition and transition through the germinal center (GC) reaction, in which mature B cells differentiate in
Externí odkaz:
https://doaj.org/article/04f4ec6920f04fe3a0d79ee8d2d2d2bd