Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Amit A Upadhyay"'
Autor:
Cordelia Manickam, Amit A Upadhyay, Griffin Woolley, Kyle W Kroll, Karen Terry, Courtney A Broedlow, Nichole R Klatt, Steven E Bosinger, R Keith Reeves
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1012223 (2024)
Natural killer-like B (NKB) cells are unique innate immune cells expressing both natural killer (NK) and B cell receptors. As first responders to infection, they secrete IL-18 to induce a critical cascade of innate and adaptive immune cell infiltrati
Externí odkaz:
https://doaj.org/article/66bb7e6cf16643e8817768d7427341ee
Autor:
Rohini Mopuri, Sarah Welbourn, Tysheena Charles, Pooja Ralli-Jain, David Rosales, Samantha Burton, Areeb Aftab, Kirti Karunakaran, Kathryn Pellegrini, William Kilembe, Etienne Karita, Sandrasegaram Gnanakaran, Amit A Upadhyay, Steven E Bosinger, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011717 (2023)
A protective HIV-1 vaccine has been hampered by a limited understanding of how B cells acquire neutralizing activity. Our previous vaccines expressing two different HIV-1 envelopes elicited robust antigen specific serum IgG titers in 20 rhesus macaqu
Externí odkaz:
https://doaj.org/article/1134d83f0e044f18b5105af8a940f58d
Autor:
Sarah Welbourn, Srirupa Chakraborty, Jie E Yang, Anne S Gleinich, Sailaja Gangadhara, Salar Khan, Courtney Ferrebee, Bhrugu Yagnik, Samantha Burton, Tysheena Charles, S Abigail Smith, Danielle Williams, Rohini Mopuri, Amit A Upadhyay, Justin Thompson, Matt A Price, Shiyu Wang, Zhaohui Qin, Xiaoying Shen, LaTonya D Williams, Nathan Eisel, Tiffany Peters, Lu Zhang, William Kilembe, Etienne Karita, Georgia D Tomaras, Steven E Bosinger, Rama R Amara, Parastoo Azadi, Elizabeth R Wright, Sandrasegaram Gnanakaran, Cynthia A Derdeyn
Publikováno v:
PLoS Pathogens, Vol 18, Iss 5, p e1010488 (2022)
Transmitted/founder (T/F) HIV-1 envelope proteins (Envs) from infected individuals that developed neutralization breadth are likely to possess inherent features desirable for vaccine immunogen design. To explore this premise, we conducted an immuniza
Externí odkaz:
https://doaj.org/article/57b66c8bac8a49fbb543e6148e785893
Autor:
Jacqueline Corry, Gwenddolen Kettenburg, Amit A Upadhyay, Megan Wallace, Michelle M Marti, Elizabeth R Wonderlich, Stephanie J Bissel, Kyndal Goss, Timothy J Sturgeon, Simon C Watkins, Douglas S Reed, Steven E Bosinger, Simon M Barratt-Boyes
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010395 (2022)
Severe influenza kills tens of thousands of individuals each year, yet the mechanisms driving lethality in humans are poorly understood. Here we used a unique translational model of lethal H5N1 influenza in cynomolgus macaques that utilizes inhalatio
Externí odkaz:
https://doaj.org/article/158a2ae8d6714870a76bb7c76eda7ece
Autor:
Michelle Y-H Lee, Amit A Upadhyay, Hasse Walum, Chi N Chan, Reem A Dawoud, Christine Grech, Justin L Harper, Kirti A Karunakaran, Sydney A Nelson, Ernestine A Mahar, Kyndal L Goss, Diane G Carnathan, Barbara Cervasi, Kiran Gill, Gregory K Tharp, Elizabeth R Wonderlich, Vijayakumar Velu, Simon M Barratt-Boyes, Mirko Paiardini, Guido Silvestri, Jacob D Estes, Steven E Bosinger
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009674 (2021)
HIV associated immune activation (IA) is associated with increased morbidity in people living with HIV (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the HIV reservoir. The underlying mechanisms of IA have no
Externí odkaz:
https://doaj.org/article/23f45ec77beb4055b59259a74d913d13
Autor:
Radhakrishna Muttineni, Nagamani Kammili, Thrilok Chander Bingi, Raja Rao M, Kalyani Putty, Pankaj Singh Dholaniya, Ravi Kumar Puli, Sunitha Pakalapati, Saritha S, Shekar K, Mallikarjuna Reddy Doodipala, Amit A Upadhyay, Steven E Bosinger, Rama R Amara, Anand K Kondapi
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246173 (2021)
We report clinical profile of hundred and nine patients with SARS CoV-2 infection, and whole genome sequences (WGS) of seven virus isolates from the first reported cases in India, with various international travel histories. Comorbidities such as dia
Externí odkaz:
https://doaj.org/article/625c4fc214b547b98d6cb04fa3a06ba7
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 4, p e1004862 (2016)
Cellular receptors usually contain a designated sensory domain that recognizes the signal. Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from bacteria to humans. Although PAS domains were described as intracellular
Externí odkaz:
https://doaj.org/article/6018e2d1358b4a4c9ebd3a8130077c0c
Autor:
Colin Havenar-Daughton, Diane G. Carnathan, Archana V. Boopathy, Amit A. Upadhyay, Ben Murrell, Samantha M. Reiss, Chiamaka A. Enemuo, Etse H. Gebru, Yury Choe, Pallavi Dhadvai, Federico Viviano, Kirti Kaushik, Jinal N. Bhiman, Bryan Briney, Dennis R. Burton, Steven E. Bosinger, William R. Schief, Darrell J. Irvine, Guido Silvestri, Shane Crotty
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1756-1766.e8 (2019)
Summary: The first immunization in a protein prime-boost vaccination is likely to be critical for how the immune response unfolds. Using fine needle aspirates (FNAs) of draining lymph nodes (LNs), we tracked the kinetics of the primary immune respons
Externí odkaz:
https://doaj.org/article/4bfc82547cda434c9a02cab1bdb35528
Autor:
Amit A. Upadhyay, Elise G. Viox, Timothy N. Hoang, Arun K. Boddapati, Maria Pino, Michelle Y.-H. Lee, Jacqueline Corry, Zachary Strongin, David A. Cowan, Elizabeth N. Beagle, Tristan R. Horton, Sydney Hamilton, Hadj Aoued, Justin L. Harper, Christopher T. Edwards, Kevin Nguyen, Kathryn L. Pellegrini, Gregory K. Tharp, Anne Piantadosi, Rebecca D. Levit, Rama R. Amara, Simon M. Barratt-Boyes, Susan P. Ribeiro, Rafick P. Sekaly, Thomas H. Vanderford, Raymond F. Schinazi, Mirko Paiardini, Steven E. Bosinger
Publikováno v:
Nature Communications. 14
The immunopathological mechanisms driving the development of severe COVID-19 remain poorly defined. Here, we utilize a rhesus macaque model of acute SARS-CoV-2 infection to delineate perturbations in the innate immune system. SARS-CoV-2 initiates a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e946d9ba9098ddd5cab7fcc5b1e47ef9
https://doi.org/10.1038/s41467-023-37425-9
https://doi.org/10.1038/s41467-023-37425-9
Autor:
Timothy N. Hoang, Elise G. Viox, Amit A. Upadhyay, Zachary Strongin, Gregory K. Tharp, Maria Pino, Rayhane Nchioua, Maximilian Hirschenberger, Matthew Gagne, Kevin Nguyen, Justin L. Harper, Shir Marciano, Arun K. Boddapati, Kathryn L. Pellegrini, Jennifer Tisoncik-Go, Leanne S. Whitmore, Kirti A. Karunakaran, Melissa Roy, Shannon Kirejczyk, Elizabeth H. Curran, Chelsea Wallace, Jennifer S. Wood, Fawn Connor-Stroud, Sudhir P. Kasturi, Rebecca D. Levit, Michael Gale, Thomas H. Vanderford, Guido Silvestri, Kathleen Busman-Sahay, Jacob D. Estes, Monica Vaccari, Daniel C. Douek, Konstantin M.J. Sparrer, Frank Kirchhoff, R. Paul Johnson, Gideon Schreiber, Steven E. Bosinger, Mirko Paiardini
Type-I interferons (IFN-I) are critical mediators of innate control of viral infections, but also drive recruitment of inflammatory cells to sites of infection, a key feature of severe COVID-19. Here, and for the first time, IFN-I signaling was modul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98becb0535e8b6bb904a81ed8536fc97
https://doi.org/10.1101/2022.10.21.512606
https://doi.org/10.1101/2022.10.21.512606
