Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Amit, Luthra"'
Autor:
Kristina N. Delgado, Jairo M. Montezuma-Rusca, Isabel C. Orbe, Melissa J. Caimano, Carson J. La Vake, Amit Luthra, Christopher M. Hennelly, Fredrick N. Nindo, Jacob W. Meyer, Letitia D. Jones, Jonathan B. Parr, Juan C. Salazar, M. Anthony Moody, Justin D. Radolf, Kelly L. Hawley
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT The resurgence of syphilis in the new millennium has called attention to the importance of a vaccine for global containment strategies. Studies with immune rabbit serum (IRS) indicate that a syphilis vaccine should elicit antibodies (Abs) th
Externí odkaz:
https://doaj.org/article/a5028a454e21422fb729d7c1f9cd8a9f
Autor:
Ashley M Groshong, André A Grassmann, Amit Luthra, Melissa A McLain, Anthony A Provatas, Justin D Radolf, Melissa J Caimano
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009725 (2021)
In this study, we examined the relationship between c-di-GMP and its only known effector protein, PlzA, in Borrelia burgdorferi during the arthropod and mammalian phases of the enzootic cycle. Using a B. burgdorferi strain expressing a plzA point mut
Externí odkaz:
https://doaj.org/article/ecf504a6e74e4a17837c52e966c55a6a
Autor:
Samanthi Herath Gedara, Evan Wood, Andrew Gustafson, Cui Liang, Shr-Hau Hung, Joshua Savage, Phuc Phan, Amit Luthra, Valérie de Crécy-Lagard, Peter Dedon, Manal A Swairjo, Dirk Iwata-Reuyl
Publikováno v:
Nucleic Acids Research. 51:3836-3854
The modified nucleosides 2′-deoxy-7-cyano- and 2′-deoxy-7-amido-7-deazaguanosine (dPreQ0 and dADG, respectively) recently discovered in DNA are the products of the bacterial queuosine tRNA modification pathway and the dpd gene cluster, the latter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3c63ff6c26c8a2fe375c08043ed2014
https://doi.org/10.1093/nar/gkad141
https://doi.org/10.1093/nar/gkad141
Autor:
Amit Luthra, Jairo M Montezuma-Rusca, Carson J La Vake, Morgan LeDoyt, Kristina N Delgado, Timothy C Davenport, Mary Fiel-Gan, Melissa J Caimano, Justin D Radolf, Kelly L Hawley
Publikováno v:
PLoS Pathogens, Vol 16, Iss 9, p e1008871 (2020)
Deconvolution of syphilis pathogenesis and selection of candidate syphilis vaccinogens requires detailed knowledge of the molecular architecture of the Treponema pallidum outer membrane (OM). The T. pallidum OM contains a low density of integral OM p
Externí odkaz:
https://doaj.org/article/9f2d3a5dcca444ddb23d923afab6a67f
Autor:
Melissa J. Caimano, Ashley M. Groshong, Alexia Belperron, Jialing Mao, Kelly L. Hawley, Amit Luthra, Danielle E. Graham, Christopher G. Earnhart, Richard T. Marconi, Linda K. Bockenstedt, Jon S. Blevins, Justin D. Radolf
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory pathway involving the alternative σ factors RpoN and RpoS and two ancillary trans-acting factors, BosR and Rrp2. Activation of this pathway occurs within tic
Externí odkaz:
https://doaj.org/article/18744cc3668a41179207794464d488a6
Autor:
Valérie de Crécy-Lagard, Manal A. Swairjo, Jo Marie Bacusmo, Christopher Deutsch, Dirk Iwata-Reuyl, William Swinehart, Amit Luthra, Paul F. Agris, Kathryn L. Sarachan
Publikováno v:
RNA. 26:1094-1103
N6-threonylcarbamoyl adenosine (t6A) is a nucleoside modification found in all kingdoms of life at position 37 of tRNAs decoding ANN codons, which functions in part to restrict translation initiation to AUG and suppress frameshifting at tandem ANN co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdd9f9fc7068e08bc47da6d991fd395a
https://doi.org/10.1261/rna.075747.120
https://doi.org/10.1261/rna.075747.120
Autor:
K Delgado, Jairo M. Montezuma-Rusca, Justin D. Radolf, Melissa J. Caimano, Amit Luthra, Kelly L. Hawley
Publikováno v:
Oral presentations.
Background The outer membrane (OM) of Treponema pallidum (Tp) serves as the interface between the syphilis spirochete and its obligate human host and also is key to developing a vaccine with worldwide efficacy. We used structural modeling and bioinfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10a0f5fc46d3073b6c329f23e0bf7c81
https://doi.org/10.1136/sextrans-2021-sti.51
https://doi.org/10.1136/sextrans-2021-sti.51
Autor:
M Moody, Jonathan J. Juliano, Melissa J. Caimano, Irving F. Hoffman, F Nindo, J Rudolf, Lucero Ramírez, Heping Zheng, Juan C. Salazar, E Lopez, Y Jiang, Jonathan B. Parr, David Šmajs, Mitch Matoga, Amit Luthra, T Davenport, Petra Pospíšilová, Li Gang Yang, Arlene C. Seña, C Hennelly, Kelly L. Hawley, Wentao Chen, Bin Yang
Publikováno v:
Late breakers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633968776eb5aea44c333ee0641d78b5
https://doi.org/10.1136/sextrans-2021-sti.167
https://doi.org/10.1136/sextrans-2021-sti.167
Autor:
H Driscoll, Kelly L. Hawley, Justin D. Radolf, S McBride, M Ferguson, Melissa J. Caimano, Amit Luthra, M Weiner, K Delgado, M Kelly, Jairo M. Montezuma-Rusca, M Moody
Publikováno v:
Poster presentations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88eeb653cd488bee840670a617e4d196
https://doi.org/10.1136/sextrans-2021-sti.431
https://doi.org/10.1136/sextrans-2021-sti.431
Autor:
Morgan LeDoyt, Kelly L. Hawley, Amit Luthra, J Montezuma Rusca, C. J. LaVake, M Moody, Melissa J. Caimano, K Delgado, Justin D. Radolf
Publikováno v:
Oral presentations.
Background Development of a vaccine is a necessary step towards curtailing the global syphilis epidemic. Towards this end, our group has utilized bioinformatic and biophysical methods to characterize T. pallidum’s repertoire of outer membrane prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b456e04cc6b99104334d860cc1e51314
https://doi.org/10.1136/sextrans-2021-sti.49
https://doi.org/10.1136/sextrans-2021-sti.49