Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Amish J. Patel"'
Autor:
Juan Yan, Yuedan Chen, Amish J. Patel, Sarah Warda, Cindy J. Lee, Briana G. Nixon, Elissa W.P. Wong, Miguel A. Miranda-Román, Ning Yang, Yi Wang, Mohini R. Pachai, Jessica Sher, Emily Giff, Fanying Tang, Ekta Khurana, Sam Singer, Yang Liu, Phillip M. Galbo Jr., Jesper L.V. Maag, Richard P. Koche, Deyou Zheng, Cristina R. Antonescu, Liang Deng, Ming O. Li, Yu Chen, Ping Chi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 17 (2022)
Immune checkpoint blockade (ICB) has demonstrated clinical success in “inflamed” tumors with substantial T cell infiltrates, but tumors with an immune-desert tumor microenvironment (TME) fail to benefit. The tumor cell–intrinsic molecular mecha
Externí odkaz:
https://doaj.org/article/5f861c04fcd24ec597718aa39450c410
Publikováno v:
Cell Reports, Vol 6, Iss 1, Pp 81-92 (2014)
Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive sarcomas that develop sporadically or in neurofibromatosis type 1 (NF1) patients. There is no effective treatment for MPNSTs and they are typically fatal. To gain insights into M
Externí odkaz:
https://doaj.org/article/39b99f00a8a44294b0cd0b667f9858f9
Autor:
Ping Chi, Yu Chen, Deyou Zheng, Cristina R. Antonescu, Jacob L. Glass, Richard P. Koche, Joseph M. Scandura, Sarat Chandarlapaty, Charles M. Rudin, Jonathan A. Fletcher, Michael T. McCabe, Melissa B. Pappalardi, Emily Giff, Juan Yan, Elissa W.P. Wong, Yinuo Meng, Eve Fishinevich, Gabriella Bayshtok, Naitao Wang, Dan Li, Cindy J. Lee, Mohini R. Pachai, Miguel A. Miranda-Román, Rohan Misra, Jesper L.V. Maag, Sarah Warda, Amish J. Patel
Polycomb repressive complex 2 (PRC2) has oncogenic and tumor-suppressive roles in cancer. There is clinical success of targeting this complex in PRC2-dependent cancers, but an unmet therapeutic need exists in PRC2-loss cancer. PRC2-inactivating mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddd2212905d2044de7e4a7a9f01b27a
https://doi.org/10.1158/2159-8290.c.6549502.v1
https://doi.org/10.1158/2159-8290.c.6549502.v1
Autor:
Ping Chi, Yu Chen, Deyou Zheng, Cristina R. Antonescu, Jacob L. Glass, Richard P. Koche, Joseph M. Scandura, Sarat Chandarlapaty, Charles M. Rudin, Jonathan A. Fletcher, Michael T. McCabe, Melissa B. Pappalardi, Emily Giff, Juan Yan, Elissa W.P. Wong, Yinuo Meng, Eve Fishinevich, Gabriella Bayshtok, Naitao Wang, Dan Li, Cindy J. Lee, Mohini R. Pachai, Miguel A. Miranda-Román, Rohan Misra, Jesper L.V. Maag, Sarah Warda, Amish J. Patel
Supplementary Data from PRC2-Inactivating Mutations in Cancer Enhance Cytotoxic Response to DNMT1-Targeted Therapy via Enhanced Viral Mimicry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f847d5ee315f0b1a992e649f77a1c97
https://doi.org/10.1158/2159-8290.22540900.v1
https://doi.org/10.1158/2159-8290.22540900.v1
Autor:
Lu Q. Le, Yong Wang, Juan Mo, Kun Chen, Chung-Ping Liao, Zhiguo Chen, Amish J. Patel, Jonathan M. Cooper
Purpose:BET bromodomain inhibitors have emerged as a promising therapy for numerous cancer types in preclinical studies, including neurofibromatosis type 1 (NF1)-associated malignant peripheral nerve sheath tumor (MPNST). However, potential mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f349b97bebee01fbc1929e7065effef
https://doi.org/10.1158/1078-0432.c.6527787
https://doi.org/10.1158/1078-0432.c.6527787
Autor:
Lu Q. Le, Yong Wang, Juan Mo, Kun Chen, Chung-Ping Liao, Zhiguo Chen, Amish J. Patel, Jonathan M. Cooper
Figure S1 shows the sequencing results for CRISPR/Cas9 gene editing to delete Brd4 in mouse MPNST cells; Figure S2 shows that BRD4 depletion overcomes resistance to BET inhibitor-induced cell death in MPNST; Figure S3 shows that genetic inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a667939bd8684a88fbb3c2ce9e98b49c
https://doi.org/10.1158/1078-0432.22471128
https://doi.org/10.1158/1078-0432.22471128
Autor:
Amish J. Patel, Nicholas B. Rego
Publikováno v:
Annual Review of Condensed Matter Physics. 13:303-324
The aversion of hydrophobic solutes for water drives diverse interactions and assemblies across materials science, biology and beyond. % Here, we review the theoretical, computational and experimental developments which underpin a contemporary unders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cf9b0afb76725e5063567ae5cb4275
https://doi.org/10.1146/annurev-conmatphys-040220-045516
https://doi.org/10.1146/annurev-conmatphys-040220-045516
Autor:
Aniket U. Thosar, Amish J. Patel
Publikováno v:
Nature Chemistry. 14:8-10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f56b1a5713feae96307ab8b8b30a47d
https://doi.org/10.1038/s41557-021-00864-2
https://doi.org/10.1038/s41557-021-00864-2
Publikováno v:
The Journal of Physical Chemistry B. 125:5434-5442
Conformational transitions of flexible molecules, especially those driven by hydrophobic effects, tend to be hindered by desolvation barriers. For such transitions, it is thus important to characterize and understand the interplay between solvation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfed37b537ee4889fc1b600e2d138d5
https://doi.org/10.1021/acs.jpcb.1c02191
https://doi.org/10.1021/acs.jpcb.1c02191
Autor:
Russell J. Composto, Na Kyung Kim, Daniel Keane, Ruiqi Dong, Yusheng Cai, Cherie R. Kagan, Uri R. Gabinet, Amish J. Patel, Sarah M. Thompson, Alexander Grun, Ryan Poling-Skutvik, Chinedum O. Osuji, Zachariah Vicars, Aniket U. Thosar, Changyeon Lee
Publikováno v:
ACS Materials Letters. 3:704-712
Atomically thin MoS2 nanosheets are of interest due to unique electronic, optical, and catalytic properties that are absent in the bulk material. Methods to prepare nanosheets from bulk material th...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d42d307d2b0309019bb55e2391904c36
https://doi.org/10.1021/acsmaterialslett.1c00222
https://doi.org/10.1021/acsmaterialslett.1c00222