Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Amirsoheil, Negahbani"'
Autor:
Brian T. Chamberlain, Boris A. Kashemirov, Amirsoheil Negahbani, Pouya Haratipour, Jorge Osuna, Michelle Zhao, Corinne Minard, Maryam Nakhjiri, Charles E. McKenna, Thomas G. Upton
Publikováno v:
The Journal of Organic Chemistry. 85:14592-14609
Nucleoside 5'-triphosphate (dNTP) analogues in which the β,γ-oxygen is mimicked by a CXY group (β,γ-CXY-dNTPs) have provided information about DNA polymerase catalysis and fidelity. Definition of CXY stereochemistry is important to elucidate prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6779f9afe0907d7b74f790da69d9357b
https://doi.org/10.1021/acs.joc.0c01204
https://doi.org/10.1021/acs.joc.0c01204
Autor:
Pouya, Haratipour, Corinne, Minard, Maryam, Nakhjiri, Amirsoheil, Negahbani, Brian T, Chamberlain, Jorge, Osuna, Thomas G, Upton, Michelle, Zhao, Boris A, Kashemirov, Charles E, McKenna
Publikováno v:
The Journal of organic chemistry. 85(22)
Nucleoside 5'-triphosphate (dNTP) analogues in which the β,γ-oxygen is mimicked by a CXY group (β,γ-CXY-dNTPs) have provided information about DNA polymerase catalysis and fidelity. Definition of CXY stereochemistry is important to elucidate prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dbf335c24a8d05ef70b5f8ca12a41a23
https://pubmed.ncbi.nlm.nih.gov/33125847
https://pubmed.ncbi.nlm.nih.gov/33125847
Autor:
Boris A. Kashemirov, Myron F. Goodman, Maryam Nakhjiri, Amirsoheil Negahbani, Joann B. Sweasy, Ivan S. Krylov, Charles E. McKenna, Khadijeh S. Alnajjar
Publikováno v:
Biochemistry. 56:5449-5456
The hydrophobic hinge region of DNA polymerase β (pol β) is located between the fingers and palm subdomains. The hydrophobicity of the hinge region is important for maintaining the geometry of the binding pocket and for selectivity of the enzyme. V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f55a21c346270d6f8a356cf44ad9caa
https://doi.org/10.1021/acs.biochem.7b00713
https://doi.org/10.1021/acs.biochem.7b00713
Autor:
Maryam Nakhjiri, Charles E. McKenna, Amirsoheil Negahbani, Boris A. Kashemirov, Beatriz Garcia-Barboza, Joann B. Sweasy, Khadijeh S. Alnajjar, Myron F. Goodman
Publikováno v:
Biochemistry. 56:2096-2105
K289M is a variant of DNA polymerase β (pol β) that has previously been identified in colorectal cancer. The expression of this variant leads to a 16-fold increase in mutation frequency at a specific site in vivo and a reduction in fidelity in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfdadc196c441334cec28b0e925d487
https://doi.org/10.1021/acs.biochem.6b01230
https://doi.org/10.1021/acs.biochem.6b01230
Autor:
Pouya Haratipour, Boris A. Kashemirov, Joann B. Sweasy, Myron F. Goodman, Ivan S. Krylov, Charles E. McKenna, Mariam M. Mahmoud, Ji Huang, Amirsoheil Negahbani, Khadijeh S. Alnajjar
Publikováno v:
Nucleic Acids Research
DNA polymerase β (pol β) selects the correct deoxyribonucleoside triphosphate for incorporation into the DNA polymer. Mistakes made by pol β lead to mutations, some of which occur within specific sequence contexts to generate mutation hotspots. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ef801ebab61335ca59bf39c4c7c701
https://pubmed.ncbi.nlm.nih.gov/31732732
https://pubmed.ncbi.nlm.nih.gov/31732732
Autor:
Corinne Minard, Vinod K. Batra, Myron F. Goodman, Amirsoheil Negahbani, Boris A. Kashemirov, Joann B. Sweasy, Keriann Oertell, Khadijeh S. Alnajjar, William A. Beard, Samuel H. Wilson, Pouya Haratipour, Charles E. McKenna
Publikováno v:
Biochemistry. 57(26)
We examine the DNA polymerase β (pol β) transition state from a leaving group presteady-state kinetics perspective by measuring the rate of incorporation of dNTPs and corresponding novel β,γ-CXY-dNTP analogues, including individual β,γ-CHF and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccddb464b93e833250daed33346fdfff
https://pubmed.ncbi.nlm.nih.gov/29889506
https://pubmed.ncbi.nlm.nih.gov/29889506
Autor:
Boris A. Kashemirov, Pouya Haratipour, Maryam Nakhjiri, Corinne Minard, Charles E. McKenna, Amirsoheil Negahbani
Publikováno v:
Phosphorus Sulfur Silicon Relat Elem
Individual diastereomers of CXY bisphosphonate analogues of dNTPs or NTPs are useful chemical stereoprobes to investigate interactions within the chiral active site environment of enzymes such as polymerases and kinases. We previously reported synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6552ec549dba30e7a2ab3f8d4e19c1f
https://doi.org/10.1080/10426507.2018.1540482
https://doi.org/10.1080/10426507.2018.1540482
Autor:
Vosooghi M, Rajabalian S, Sorkhi M, Badinloo M, Nakhjiri M, Amirsoheil Negahbani, Asadipour A, Mahdavi M, Shafiee A, Foroumadi A
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Research in Pharmaceutical Sciences
Europe PubMed Central
Research in Pharmaceutical Sciences
A series of 2-amino-4-aryl-3-cyano-7- (dimethylamino)-4H-chromenes was synthesized by condensation of 3- (dimethylamino) phenol, an aromatic aldehyde and malonitrile in ethanol containing piperidine. The assignments of the structure of all synthesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::62a50c26430bae443710e429ddd18f01
http://www.scopus.com/inward/record.url?eid=2-s2.0-78650667629&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-78650667629&partnerID=MN8TOARS
