Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Amiran K Dzutsev"'
Autor:
Jyothi Padiadpu, Manuel Garcia‐Jaramillo, Nolan K Newman, Jacob W Pederson, Richard Rodrigues, Zhipeng Li, Sehajvir Singh, Philip Monnier, Giorgio Trinchieri, Kevin Brown, Amiran K Dzutsev, Natalia Shulzhenko, Donald B Jump, Andrey Morgun
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-21 (2023)
Abstract Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive.
Externí odkaz:
https://doaj.org/article/d61e92523d9e4acf87080e7f0b5b8143
Autor:
Ashwin Ajith, Kenza Mamouni, Daniel D. Horuzsko, Abu Musa, Amiran K. Dzutsev, Jennifer R. Fang, Ahmed Chadli, Xingguo Zhu, Iryna Lebedyeva, Giorgio Trinchieri, Anatolij Horuzsko
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 21 (2023)
The triggering receptor expressed on myeloid cell 1 (TREM1) plays a critical role in development of chronic inflammatory disorders and the inflamed tumor microenvironment (TME) associated with most solid tumors. We examined whether loss of TREM1 sign
Externí odkaz:
https://doaj.org/article/5bb71203ab174a6d97240f62410448ca
Autor:
Hai, Liang, Jay-Hyun, Jo, Zhiwei, Zhang, Margaret A, MacGibeny, Jungmin, Han, Diana M, Proctor, Monica E, Taylor, You, Che, Paul, Juneau, Andrea B, Apolo, John A, McCulloch, Diwakar, Davar, Hassane M, Zarour, Amiran K, Dzutsev, Isaac, Brownell, Giorgio, Trinchieri, James L, Gulley, Heidi H, Kong
Publikováno v:
Oncotarget. 13:876-889
Cancer immunotherapy has significantly improved patient survival. Yet, half of patients do not respond to immunotherapy. Gut microbiomes have been linked to clinical responsiveness of melanoma patients on immunotherapies; however, different taxa have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04458b92c7516946305bd33d8219fdf0
https://doi.org/10.18632/oncotarget.28252
https://doi.org/10.18632/oncotarget.28252
Autor:
Turan Aghayev, Aleksandra M. Mazitova, Jennifer R. Fang, Iuliia O. Peshkova, Matthew Rausch, Manhsin Hung, Kerry F. White, Ricard Masia, Elizaveta K. Titerina, Aliia R. Fatkhullina, Isabelle Cousineau, Simon Turcotte, Dmitry Zhigarev, Anastasiia Marchenko, Svetlana Khoziainova, Petr Makhov, Yin Fei Tan, Andrew V. Kossenkov, David L. Wiest, John Stagg, Xin Wei Wang, Kerry S. Campbell, Amiran K. Dzutsev, Giorgio Trinchieri, Jonathan A. Hill, Sergei I. Grivennikov, Ekaterina K. Koltsova
Publikováno v:
Cancer Discov
Although inflammatory mechanisms driving hepatocellular carcinoma (HCC) have been proposed, the regulators of anticancer immunity in HCC remain poorly understood. We found that IL27 receptor (IL27R) signaling promotes HCC development in vivo. High IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b42bb7609baab1cde84e56f1ce8cef
https://doi.org/10.1158/2159-8290.cd-20-1628
https://doi.org/10.1158/2159-8290.cd-20-1628
Autor:
Ekaterina K. Koltsova, Sergei I. Grivennikov, Jonathan A. Hill, Giorgio Trinchieri, Amiran K. Dzutsev, Kerry S. Campbell, Xin Wei Wang, John Stagg, David L. Wiest, Andrew V. Kossenkov, Yin Fei Tan, Petr Makhov, Svetlana Khoziainova, Anastasiia Marchenko, Dmitry Zhigarev, Simon Turcotte, Isabelle Cousineau, Aliia R. Fatkhullina, Elizaveta K. Titerina, Ricard Masia, Kerry F. White, Manhsin Hung, Matthew Rausch, Iuliia O. Peshkova, Jennifer R. Fang, Aleksandra M. Mazitova, Turan Aghayev
Supplementary Data from IL27 Signaling Serves as an Immunologic Checkpoint for Innate Cytotoxic Cells to Promote Hepatocellular Carcinoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6efd13a825c7040a930bdf2b3cbab6b2
https://doi.org/10.1158/2159-8290.22541261.v1
https://doi.org/10.1158/2159-8290.22541261.v1
Autor:
Ekaterina K. Koltsova, Sergei I. Grivennikov, Jonathan A. Hill, Giorgio Trinchieri, Amiran K. Dzutsev, Kerry S. Campbell, Xin Wei Wang, John Stagg, David L. Wiest, Andrew V. Kossenkov, Yin Fei Tan, Petr Makhov, Svetlana Khoziainova, Anastasiia Marchenko, Dmitry Zhigarev, Simon Turcotte, Isabelle Cousineau, Aliia R. Fatkhullina, Elizaveta K. Titerina, Ricard Masia, Kerry F. White, Manhsin Hung, Matthew Rausch, Iuliia O. Peshkova, Jennifer R. Fang, Aleksandra M. Mazitova, Turan Aghayev
Although inflammatory mechanisms driving hepatocellular carcinoma (HCC) have been proposed, the regulators of anticancer immunity in HCC remain poorly understood. We found that IL27 receptor (IL27R) signaling promotes HCC development in vivo. High IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0488eaf43d501ff25edc4bae4c3d2bba
https://doi.org/10.1158/2159-8290.c.6549593.v1
https://doi.org/10.1158/2159-8290.c.6549593.v1
Autor:
Nolan K. Newman, Matthew Macovsky, Richard R. Rodrigues, Amanda M. Bruce, Jacob W. Pederson, Sankalp S Patil, Jyothi Padiadpu, Amiran K. Dzutsev, Natalia Shulzhenko, Giorgio Trinchieri, Kevin Brown, Andrey Morgun
Technological advances have generated tremendous amounts of high-throughput omics data. Integrating data from multiple cohorts and diverse omics types from new and previously published studies can offer a holistic view of a biological system and aid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f207df1aaad4db1f0498e3df1713091e
https://doi.org/10.1101/2023.02.22.529449
https://doi.org/10.1101/2023.02.22.529449
Autor:
Jyothi Padiadpu, Manuel Garcia-Jaramillo, Nolan K. Newman, Jacob W. Pederson, Richard Rodrigues, Zhipeng Li, Sehajvir Singh, Philip Monnier, Giorgio Trinchieri, Kevin Brown, Amiran K. Dzutsev, Natalia Shulzhenko, Donald B. Jump, Andrey Morgun
Clinical and preclinical studies have established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH). Herein, we used multi-omic network analysis to unveil novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e1278187334c51548c375181165e9d
https://doi.org/10.1101/2022.10.03.510635
https://doi.org/10.1101/2022.10.03.510635
Autor:
Zhipeng Li, Manoj Gurung, Richard R. Rodrigues, Jyothi Padiadpu, Nolan K. Newman, Nathan P. Manes, Jacob W. Pederson, Renee L. Greer, Stephany Vasquez-Perez, Hyekyoung You, Kaito A. Hioki, Zoe Moulton, Anna Fel, Dominic De Nardo, Amiran K. Dzutsev, Aleksandra Nita-Lazar, Giorgio Trinchieri, Natalia Shulzhenko, Andrey Morgun
Publikováno v:
Journal of Experimental Medicine. 219
Microbiota contribute to the induction of type 2 diabetes by high-fat/high-sugar (HFHS) diet, but which organs/pathways are impacted by microbiota remain unknown. Using multiorgan network and transkingdom analyses, we found that microbiota-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a11cd6fa816170bef5fceb54e756739
https://doi.org/10.1084/jem.20220017
https://doi.org/10.1084/jem.20220017
Autor:
Richelle DeBlasio, Marie Vétizou, Jonathan H. Badger, Giorgio Trinchieri, Stephanie Prescott, Hassane M. Zarour, Miriam R. Fernandes, John A. McCulloch, Bochra Zidi, Richard R. Rodrigues, Amir A. Borhani, Yana G. Najjar, Amy Rose, John M. Kirkwood, Shuowen Zhang, Hong Wang, Carmine Menna, Quanquan Ding, Scarlett J. Ernst, Amiran K. Dzutsev, Alicia M. Cole, Joe Marc Chauvin, Robert M. Morrison, Ornella Pagliano, Diwakar Davar, Andrey Morgun, Ascharya K. Balaji, Raquel Galvão Figueredo Costa, Howard M. Dubner, Ivan Vujkovic-Cvijin, Yasmine Belkaid, Marc Schwartz
Publikováno v:
Science. 371:595-602
New fecal microbiota for cancer patients The composition of the gut microbiome influences the response of cancer patients to immunotherapies. Baruch et al. and Davar et al. report first-in-human clinical trials to test whether fecal microbiota transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06cda59c60ac26ba7edf8744836a549a
https://doi.org/10.1126/science.abf3363
https://doi.org/10.1126/science.abf3363