Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Amirali Popat"'
Publikováno v:
Bioactive Materials, Vol 33, Iss , Pp 396-423 (2024)
Glioblastoma (GBM) is an aggressive malignancy of the central nervous system (CNS) that remains incurable despite the multitude of improvements in cancer therapeutics. The conventional chemo and radiotherapy post-surgery have only been able to improv
Externí odkaz:
https://doaj.org/article/45593be6dc9945f88898f6d02980024f
Autor:
Roman Schmid, Meta Volcic, Stephan Fischer, Zhi Qu, Holger Barth, Amirali Popat, Frank Kirchhoff, Mika Lindén
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Besides the many advantages of oral drug administration, challenges like premature drug degradation and limited bioavailability in the gastro-intestinal tract (GIT) remain. A prolonged residence time in the GIT is beneficial for enhancing th
Externí odkaz:
https://doaj.org/article/198c17b3a0674e07aabc4ae82a70674e
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S646- (2023)
Externí odkaz:
https://doaj.org/article/75ef5f0630e647738a880eba7d4a405e
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2239 (2023)
The presence of the blood–brain barrier (BBB) limits the delivery of therapies into the brain. There has been significant interest in overcoming the BBB for the effective delivery of therapies to the brain. Inorganic nanomaterials, especially silic
Externí odkaz:
https://doaj.org/article/7c4d34682d5541669347bf2f736f9955
Publikováno v:
Molecules, Vol 28, Iss 5, p 2114 (2023)
Sortase A (SrtA) is an enzyme which attaches proteins, including virulence factors, to bacterial cell walls. It is a potential target for developing anti-virulence agents against pathogenic and antimicrobial resistant bacteria. This study aimed to en
Externí odkaz:
https://doaj.org/article/2df13faf8a524a91979f82671c8db710
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 986 (2022)
This study aimed to develop synergistic therapies to treat superbug infections through the encapsulation of sortase A inhibitors (SrtAIs; trans-chalcone (TC), curcumin (CUR), quercetin (QC), or berberine chloride (BR)) into MCM-41 mesoporous silica n
Externí odkaz:
https://doaj.org/article/5c8831e9540d4dce930cb975b687e8dd
Autor:
Zanib Chaudhary, Sugarniya Subramaniam, Gul Majid Khan, Muhammad Mustafa Abeer, Zhi Qu, Taskeen Janjua, Tushar Kumeria, Jyotsna Batra, Amirali Popat
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Resveratrol (RES) is a naturally existing polyphenol which exhibits anti-oxidant, anti-inflammatory, and anti-cancer properties. In recent years, RES has attracted attention for its synergistic effect with other anti-cancer drugs for the treatment of
Externí odkaz:
https://doaj.org/article/aeb4ff56e84a4081b335ac20b4a88951
Autor:
Sachin S Thakur, Micheal S Ward, Amirali Popat, Nicole B Flemming, Marie-Odile Parat, Nigel L Barnett, Harendra S Parekh
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178305 (2017)
Herein we showcase the potential of ultrasound-responsive nanobubbles in enhancing macromolecular permeation through layers of the retina, ultimately leading to significant and direct intracellular delivery; this being effectively demonstrated across
Externí odkaz:
https://doaj.org/article/8c348a97c3884acaacf223e5babfeb97
Autor:
Muhammad Mustafa Abeer, Anand Kumar Meka, Naisarg Pujara, Tushar Kumeria, Ekaterina Strounina, Rute Nunes, Ana Costa, Bruno Sarmento, Sumaira Z. Hasnain, Benjamin P. Ross, Amirali Popat
Publikováno v:
Pharmaceutics, Vol 11, Iss 8, p 418 (2019)
Type 2 diabetes makes up approximately 85% of all diabetic cases and it is linked to approximately one-third of all hospitalisations. Newer therapies with long-acting biologics such as glucagon-like peptide-1 (GLP-1) analogues have been promising in
Externí odkaz:
https://doaj.org/article/86939cae247147a39ccaabc4f99385e7
Autor:
Anand Kumar Meka, Laura J. Jenkins, Mercedes Dàvalos-Salas, Naisarg Pujara, Kuan Yau Wong, Tushar Kumeria, John M. Mariadason, Amirali Popat
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 283 (2018)
Suberoylanilide hydroxamic acid (SAHA) or vorinostat (VOR) is a potent inhibitor of class I histone deacetylases (HDACs) that is approved for the treatment of cutaneous T-cell lymphoma. However, it has the intrinsic limitations of low water solubilit
Externí odkaz:
https://doaj.org/article/154aac8a93fd460298063a9649fab905