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Akademický článek

Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice

Autor: Benjamin A. Kugler, Jared Lourie, Nicolas Berger, Nana Lin, Paul Nguyen, Edzana DosSantos, Abir Ali, Amira Sesay, H. Grace Rosen, Baby Kalemba, Gregory M. Hendricks, Joseph A. Houmard, Hiromi Sesaki, Philimon Gona, Tongjian You, Zhen Yan, Kai Zou

Publikováno v: Molecular Metabolism, Vol 77, Iss , Pp 101802- (2023)

Objective: Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported a strong correlation between enhanced Drp1 activity and impaired skeletal muscle insulin sensitivity. This study aimed to determine

Externí odkaz: https://doaj.org/article/2a6dac4c2dd4468298c7721d261959bb

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148-OR: Partial Knockout of Skeletal Muscle Dynamin-Related Protein 1 Improves Insulin Sensitivity in Diet-Induced Insulin Resistant Mice, but Not in Normal Control Mice

Autor: BENJAMIN A. KUGLER, NANA LIN, PAUL D. NGUYEN, ABIR ALI, AMIRA SESAY, BABY LENGA KALEMBA, HIROMI SESAKI, KAI ZOU

Publikováno v: Diabetes. 71

Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported excessive Drp1 activity in skeletal muscle from both animals and humans with insulin resistance, which is strongly correlated to impaired skel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ceed77bf52c8eddd08cb969285b69f1
https://doi.org/10.2337/db22-148-or

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