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pro vyhledávání: '"Amira Mohammed Fitieh"'
Autor:
Ajit K. Sharma, Amira Mohammed Fitieh, Andrew J. Locke, Jana Yasser Hafez Ali, Ismail Hassan Ismail
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101917- (2023)
Summary: Here, we present a chromatin-immunoprecipitation-based protocol to quantify the recruitment of proteins adjacent to site-specific DNA double-strand breaks (DSBs), such as proteins involved in DSB repair. We describe steps to induce DSBs in U
Externí odkaz:
https://doaj.org/article/b7ab18c768fd4966b7d86e69e1696ec8
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101861- (2022)
Summary: DNA end resection is a critical step in the homologous recombination pathway of repairing DNA double-strand breaks (DSBs) that can be visualized in cells by detecting the generation of single-stranded DNA (ssDNA) intermediates formed during
Externí odkaz:
https://doaj.org/article/a4cdbf69961c4cf78a607714948f3616
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5688 (2022)
Multiple Myeloma (MM) is a B cell malignancy marked by genomic instability that arises both through pathogenesis and during disease progression. Despite recent advances in therapy, MM remains incurable. Recently, it has been reported that DNA repair
Externí odkaz:
https://doaj.org/article/546637ac35264e208d0e6e72e6065e42
Autor:
Ajit K. Sharma, Amira Mohammed Fitieh, Andrew J. Locke, Jana Yasser Hafez Ali, Ismail Hassan Ismail
Publikováno v:
STAR protocols. 4(1)
Here, we present a chromatin-immunoprecipitation-based protocol to quantify the recruitment of proteins adjacent to site-specific DNA double-strand breaks (DSBs), such as proteins involved in DSB repair. We describe steps to induce DSBs in U2OS osteo