Zobrazeno 1 - 10
of 363
pro vyhledávání: '"Amira Klip"'
Autor:
Eshwar R Tammineni, Lourdes Figueroa, Carlo Manno, Disha Varma, Natalia Kraeva, Carlos A Ibarra, Amira Klip, Sheila Riazi, Eduardo Rios
Publikováno v:
eLife, Vol 12 (2023)
Calcium ion movements between cellular stores and the cytosol govern muscle contraction, the most energy-consuming function in mammals, which confers skeletal myofibers a pivotal role in glycemia regulation. Chronic myoplasmic calcium elevation (“c
Externí odkaz:
https://doaj.org/article/5333c0d70b9d492dab05f804a377068f
Autor:
Scott Frendo-Cumbo, Taoyingnan Li, Dustin A. Ammendolia, Etienne Coyaud, Estelle M.N. Laurent, Yuan Liu, Philip J. Bilan, Gordon Polevoy, Brian Raught, Julie A. Brill, Amira Klip, John H. Brumell
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105188- (2022)
Summary: Cell proliferation is dependent on growth factors insulin and IGF1. We sought to identify interactors of IRS1, the most proximal mediator of insulin/IGF1 signaling, that regulate cell proliferation. Using proximity-dependent biotin identific
Externí odkaz:
https://doaj.org/article/ac64290d00ae465c951ce30b06a4ac90
Autor:
Parastoo Boroumand, David C Prescott, Tapas Mukherjee, Philip J Bilan, Michael Wong, Jeff Shen, Ivan Tattoli, Yuhuan Zhou, Angela Li, Tharini Sivasubramaniyam, Nancy Shi, Lucie Y Zhu, Zhi Liu, Clinton Robbins, Dana J Philpott, Stephen E Girardin, Amira Klip
Publikováno v:
eLife, Vol 11 (2022)
During obesity and high fat-diet (HFD) feeding in mice, sustained low-grade inflammation includes not only increased pro-inflammatory macrophages in the expanding adipose tissue, but also bone marrow (BM) production of invasive Ly6Chigh monocytes. As
Externí odkaz:
https://doaj.org/article/f814826c238d44d7839ebe163a29ca19
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Insulin is a paramount anabolic hormone that promotes energy-storage in adipose tissue, skeletal muscle and liver, and these responses are significantly attenuated in insulin resistance leading to type 2 diabetes. Contrasting with insulin’s functio
Externí odkaz:
https://doaj.org/article/110d5782767f4a928f4e6bd60dd32296
Autor:
Eshwar R Tammineni, Natalia Kraeva, Lourdes Figueroa, Carlo Manno, Carlos A Ibarra, Amira Klip, Sheila Riazi, Eduardo Rios
Publikováno v:
eLife, Vol 9 (2020)
Most glucose is processed in muscle, for energy or glycogen stores. Malignant Hyperthermia Susceptibility (MHS) exemplifies muscle conditions that increase [Ca2+]cytosol. 42% of MHS patients have hyperglycemia. We show that phosphorylated glycogen ph
Externí odkaz:
https://doaj.org/article/3ca236418179487d915c08daff42b9d2
Autor:
Nicolas J. Pillon, Scott Frendo-Cumbo, Maya R. Jacobson, Zhi Liu, Paul L. Milligan, Hai Hoang Bui, Juleen R. Zierath, Philip J. Bilan, Joseph T. Brozinick, Amira Klip
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1148-1163 (2018)
Ceramides contribute to obesity-linked insulin resistance and inflammation in vivo, but whether this is a cell-autonomous phenomenon is debated, particularly in muscle, which dictates whole-body glucose uptake. We comprehensively analyzed lipid speci
Externí odkaz:
https://doaj.org/article/7ce1e2b5a0df4eedb6bd2c3a76980825
Publikováno v:
Data in Brief, Vol 14, Iss C, Pp 329-336 (2017)
The data presented in this article are related to the research article entitled “Regulation of GLUT4 activity in myotubes by 3-O-methyl-D-glucose” (Shamni et al., 2017) [1]. These data show that the experimental procedures used to analyze the eff
Externí odkaz:
https://doaj.org/article/6d1f42f8437e4793a8d333a3b136650d
Autor:
Kenny L. Chan, Theresa H. Tam, Parastoo Boroumand, David Prescott, Sheila R. Costford, Nichole K. Escalante, Noah Fine, YuShan Tu, Susan J. Robertson, Dilshaayee Prabaharan, Zhi Liu, Philip J. Bilan, Michael W. Salter, Michael Glogauer, Stephen E. Girardin, Dana J. Philpott, Amira Klip
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2415-2426 (2017)
Insulin resistance is a chronic inflammatory condition accompanying obesity or high fat diets that leads to type 2 diabetes. It is hypothesized that lipids and gut bacterial compounds in particular contribute to metabolic inflammation by activating t
Externí odkaz:
https://doaj.org/article/d27abc9d34b1483fb1014debca2d6c7b
Autor:
Kevin P. Foley, Amira Klip
Publikováno v:
Biology Open, Vol 3, Iss 5, Pp 314-325 (2014)
GLUT4 constitutively recycles between the plasma membrane and intracellular depots. Insulin shifts this dynamic equilibrium towards the plasma membrane by recruiting GLUT4 to the plasma membrane from insulin-responsive vesicles. Muscle is the primary
Externí odkaz:
https://doaj.org/article/818235bf1b894a2c96ff46393d360118
Publikováno v:
Cells, Vol 8, Iss 5, p 434 (2019)
Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular functions, including actin cytoskeleton remodeling and vesicle traffic. Traditionally, Rho GTPases are studied because of their function in cell migration and cancer,
Externí odkaz:
https://doaj.org/article/1b3a8a879e66492d93e079195af1680f