Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amira D. Mahmoud"'
Autor:
Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Unlike AMPK, Liver kinase B1 (LBK1) is required for carotid body chemosensing and the hypoxic ventilatory response. Moreover, loss of LBK1, but not AMPK, provokes Cheyne-Stokes-like breathing during hypoxia, which is associated with heart failure.
Externí odkaz:
https://doaj.org/article/b2f40950c892468d9001b1c437412b1e
Autor:
Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/13d010bbbbb043198eb9f05b25e647fe
Autor:
Marion J.J. Gijbels, Mukesh Kumar Lalwani, Matthew R. Bennett, Jessica P. Scanlon, Dónal O'Carroll, Kim van Kuijk, Francesca Vacante, David E. Newby, Amanda C Doran, Amira D. Mahmoud, Andrew H. Baker, Thomas C Williams, Judith C. Sluimer, Patrick W. F. Hadoke, Mauro Giacca, Michael B. Clark, Laura Denby, Rusty L. Montgomery, Jenny de Bruijn, Eileen Miller, Julie Rodor, Azzurra L De Pace
Publikováno v:
Circulation research, 128(9), 1258-1275. Lippincott Williams and Wilkins
Circulation Research, 128(9), 1258-1275. LIPPINCOTT WILLIAMS & WILKINS
Circ Res
Vacante, F, Rodor, J, Lalwani, M, Mahmoud, A, Bennett, M, De Pace, A, Miller, E, van Kuijk, K, de Bruijn, J, Gijbels, M, Williams, T C, Clark, M, Scanlon, J, Doran, A, Montgomery, R, Newby, D E, Giacca, M, O'Carroll, D, Hadoke, P W F, Denby, L, Sluimer, J & Baker, A H 2021, ' CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice ', Circulation Research . https://doi.org/10.1161/CIRCRESAHA.120.318688
Circulation Research, 128(9), 1258-1275. LIPPINCOTT WILLIAMS & WILKINS
Circ Res
Vacante, F, Rodor, J, Lalwani, M, Mahmoud, A, Bennett, M, De Pace, A, Miller, E, van Kuijk, K, de Bruijn, J, Gijbels, M, Williams, T C, Clark, M, Scanlon, J, Doran, A, Montgomery, R, Newby, D E, Giacca, M, O'Carroll, D, Hadoke, P W F, Denby, L, Sluimer, J & Baker, A H 2021, ' CARMN loss regulates smooth muscle cells and accelerates atherosclerosis in mice ', Circulation Research . https://doi.org/10.1161/CIRCRESAHA.120.318688
Rationale: In the microenvironment of atherosclerotic lesions, vascular smooth muscle cells (vSMCs) switch to a dedifferentiated state but the underlying molecular mechanisms driving this switch are not fully understood. Long noncoding RNAs (lncRNAs)
Autor:
Igor Ulitsky, Amira D. Mahmoud, Iraide Alloza, Julie Rodor, Margaret D. Ballantyne, Koen Vandenbroeck, Andrew H. Baker, Matthew R. Bennett, Vladislav Miscianinov
Publikováno v:
Addi. Archivo Digital para la Docencia y la Investigación
Universidad de Cantabria (UC)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
International Journal of Molecular Sciences, Vol 22, Iss 1484, p 1484 (2021)
Bennett, M, Ulitsky, I, Alloza, I, Vandenbroeck, K, Miscianinov, V, Mahmoud, A, Ballantyne, M, Rodor, J & Baker, A H 2021, ' Novel transcript discovery expands the repertoire of pathologically-associated, long non-coding RNAs in vascular smooth muscle cells ', International Journal of Molecular Sciences . https://doi.org/10.3390/ijms22031484
International Journal of Molecular Sciences
Volume 22
Issue 3
instname
Universidad de Cantabria (UC)
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
International Journal of Molecular Sciences, Vol 22, Iss 1484, p 1484 (2021)
Bennett, M, Ulitsky, I, Alloza, I, Vandenbroeck, K, Miscianinov, V, Mahmoud, A, Ballantyne, M, Rodor, J & Baker, A H 2021, ' Novel transcript discovery expands the repertoire of pathologically-associated, long non-coding RNAs in vascular smooth muscle cells ', International Journal of Molecular Sciences . https://doi.org/10.3390/ijms22031484
International Journal of Molecular Sciences
Volume 22
Issue 3
instname
Vascular smooth muscle cells (VSMCs) provide vital contractile force within blood vessel walls, yet can also propagate cardiovascular pathologies through proliferative and pro-inflammatory activities. Such phenotypes are driven, in part, by the diver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e80f243314399cc7f92294977e0fb98
http://hdl.handle.net/10810/50092
http://hdl.handle.net/10810/50092
Autor:
Amira D. Mahmoud, Jessica P. Scanlon, John Hung, Julie Rodor, Erik A.L. Biessen, Lieve Temmerman, Judith C. Sluimer, Margaret D. Ballantyne, Jakub Kaczynski, Margaux A.C. Fontaine, Andrew H. Baker, Raghu Bhushan, Katie Connor, David E. Newby
Publikováno v:
Arteriosclerosis Thrombosis and Vascular Biology, 40(3), 697-713. LIPPINCOTT WILLIAMS & WILKINS
Hung, J, Scanlon, J, Mahmoud, A, Rodor, J, Fontaine, M, Temmerman, L, Connor, K, Kaczynski, J, Bhushan, R, Biessen, E, Newby, D E, Sluimer, J & Baker, A H 2019, ' A Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON) ', Arteriosclerosis, Thrombosis, and Vascular Biology . https://doi.org/10.1161/ATVBAHA.119.313430
Hung, J, Scanlon, J, Mahmoud, A, Rodor, J, Fontaine, M, Temmerman, L, Connor, K, Kaczynski, J, Bhushan, R, Biessen, E, Newby, D E, Sluimer, J & Baker, A H 2019, ' A Novel Plaque Enriched Long Noncoding RNA in Atherosclerotic Macrophage Regulation (PELATON) ', Arteriosclerosis, Thrombosis, and Vascular Biology . https://doi.org/10.1161/ATVBAHA.119.313430
Objective: Long noncoding RNAs (lncRNAs) are an emergent class of molecules with diverse functional roles, widely expressed in human physiology and disease. Although some lncRNAs have been identified in cardiovascular disease, their potential as nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f4bafa73e4d0ee02b245daee24b5005
https://cris.maastrichtuniversity.nl/en/publications/a32e5cda-aaf6-4e35-b445-5924f2ea4ba1
https://cris.maastrichtuniversity.nl/en/publications/a32e5cda-aaf6-4e35-b445-5924f2ea4ba1
Autor:
Judith C. Sluimer, Gwyn W. Gould, Adriana Tavares, John Hung, Julie Rodor, Jean Iyinikkel, Andrea Caporali, Jessica P. Scanlon, Andrew H. Baker, Amira D. Mahmoud, Angela C. Bradshaw, Jakub Kaczynski, Sarah J George, Nicholas L. Mills, Margaret D. Ballantyne, David E. Newby, Vladislav Miscianinov, Igor Ulitsky, Karine Pinel
Publikováno v:
Mahmoud, A, Ballantyne, M, Miscianinov, V, Pinel, K, Hung, J, Scanlon, J, Iyinikkel, J, Kaczynski, J, Tavares, A, Bradshaw, A, Mills, N, Newby, D, Caporali, A, Gould, G, George, S, Vlitsky, I, Sluimer, J, Rodor, J & Baker, A 2019, ' The Human-Specific and Smooth Muscle Cell-Enriched lncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling ', Circulation Research, vol. 125 (2019), no. 5, pp. 535-551 . https://doi.org/10.1161/CIRCRESAHA.119.314876
Circulation Research
Mahmoud, A D, Ballantyne, M D, Miscianinov, V, Pinel, K, Hung, J, Scanlon, J P, Iyinikkel, J, Kaczynski, J, Tavares, A S, Bradshaw, A C, Mills, N L, Newby, D E, Caporali, A, Gould, G W, George, S J, Ulitsky, I, Sluimer, J C, Rodor, J & Baker, A H 2019, ' The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling. ', Circulation Research, vol. 125, no. 5, pp. 535–551 . https://doi.org/10.1161/CIRCRESAHA.119.314876
Circulation Research, 125(5), 535-551. LIPPINCOTT WILLIAMS & WILKINS
Circulation Research
Mahmoud, A D, Ballantyne, M D, Miscianinov, V, Pinel, K, Hung, J, Scanlon, J P, Iyinikkel, J, Kaczynski, J, Tavares, A S, Bradshaw, A C, Mills, N L, Newby, D E, Caporali, A, Gould, G W, George, S J, Ulitsky, I, Sluimer, J C, Rodor, J & Baker, A H 2019, ' The Human-Specific and Smooth Muscle Cell-Enriched LncRNA SMILR Promotes Proliferation by Regulating Mitotic CENPF mRNA and Drives Cell-Cycle Progression Which Can Be Targeted to Limit Vascular Remodeling. ', Circulation Research, vol. 125, no. 5, pp. 535–551 . https://doi.org/10.1161/CIRCRESAHA.119.314876
Circulation Research, 125(5), 535-551. LIPPINCOTT WILLIAMS & WILKINS
Supplemental Digital Content is available in the text.
Rationale: In response to blood vessel wall injury, aberrant proliferation of vascular smooth muscle cells (SMCs) causes pathological remodeling. However, the controlling mechanisms are not
Rationale: In response to blood vessel wall injury, aberrant proliferation of vascular smooth muscle cells (SMCs) causes pathological remodeling. However, the controlling mechanisms are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db9b4e191ff20deb4144190fe9adafc
https://hdl.handle.net/1983/05c13a0a-7a05-4472-b9bc-5cf31b10c451
https://hdl.handle.net/1983/05c13a0a-7a05-4472-b9bc-5cf31b10c451
Autor:
C. N. Wyatt, Oluseye A. Ogunbayo, Sandy MacMillan, Benoit Viollet, Andrew P. Holmes, A. M. Evans, M. Dallas, Marc Foretz, Prem Kumar, Amira D. Mahmoud
We recently demonstrated that the role of the AMP-activated protein kinase (AMPK), a ubiquitously expressed enzyme that governs cell-autonomous metabolic homeostasis, has been extended to system-level control of breathing and thus oxygen and energy (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89aed5173d23746e9ea63a8980120e70
Autor:
A. L. Fowden, A. M. Evans, Josephine Higgins, Amanda N. Sferruzzi-Perri, Hong Wa Yung, Lorna G. Moore, Katie L. Skeffington, Amira D. Mahmoud, Dino A. Giussani, Graham J. Burton
Publikováno v:
The Journal of Physiology. 594:1357-1369
Key points Uterine artery vasodilatation is a key mechanism for increasing utero-placental blood flow and fetal nutrient supply. Since the pioneering work of Joseph Barcroft, the natural laboratory of high altitude has been used to study the mechanis
Publikováno v:
The Biochemical journal. 473(17)
Regulation of breathing is critical to our capacity to accommodate deficits in oxygen availability and demand during, for example, sleep and ascent to altitude. It is generally accepted that a fall in arterial oxygen increases afferent discharge from
Autor:
Javier, Moral-Sanz, Amira D, Mahmoud, Fiona A, Ross, Jodene, Eldstrom, David, Fedida, D Grahame, Hardie, A Mark, Evans
Publikováno v:
The Journal of Physiology
Key points Progression of hypoxic pulmonary hypertension is thought to be due, in part, to suppression of voltage‐gated potassium channels (Kv) in pulmonary arterial smooth muscle by hypoxia, although the precise molecular mechanisms have been uncl