LRP1 : A Novel Mediator of Tau Uptake

Autor: Maria Stamelou, Günter U. Höglinger, Amir Tayaranian Marvian

Publikováno v: Movement disorders 35(7), 1136-1136 (2020). doi:10.1002/mds.28107

Propagation of intracellular tau inclusions is found to be associated with the progress of symptoms in various neurodegenerative diseases.1 A growing body of evidence suggests that tau pathology spreads via a prion‐like mechanism, through which cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d907cf033a6ab5abf9b57fa265277191
https://doi.org/10.1002/mds.28107

The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease

Autor: Faezeh Dehghani Esmatabad, Farhang Aliakbari, Markus Zweckstetter, Hassan Bardania, Hossein Mohammad-Beigi, Hadieh Alsadat Eslampanah Seyedi, Amir Tayaranian Marvian, Daniel E. Otzen, Nasrollah Rezaei-Ghaleh, Gunna Christiansen, Stefan Becker, Joanna F. Collingwood, Dina Morshedi

Publikováno v: Nanoscale 10(19), 9174-9185 (2018). doi:10.1039/C8NR00632F
Aliakbari, F, Mohammad-Beigi, H, Rezaei-Ghaleh, N, Becker, S, Dehghani Esmatabad, F, Eslampanah Seyedi, H A, Bardania, H, Tayaranian Marvian, A, Collingwood, J F, Christiansen, G, Zweckstetter, M, Otzen, D E & Morshedi, D 2018, ' The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease ', Nanoscale, vol. 10, no. 19, pp. 9174-9185 . https://doi.org/10.1039/c8nr00632f
Nanoscale

The protein α-synuclein (αSN) aggregates to form fibrils in neuronal cells of Parkinson's patients. Here we report on the effect of neutral (zwitterionic) nanoliposomes (NLPs), supplemented with cholesterol (NLP-Chol) and decorated with PEG (NLP-Ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d891919648f62b6f8721fa6a28119f14
http://wrap.warwick.ac.uk/101928/7/WRAP-potential-zwitterionic-nanoliposomes-neurotoxic-alpha-synuclein-Collingwood-2018.pdf

Alpha-Synuclein Fibrils Interact with Dopamine Reducing its Cytotoxicity on PC12 Cells

Autor: Amir Tayaranian Marvian, Sadegh Azimzadeh Jamalkandi, Dina Morshedi, Farhang Aliakbari, Hossein Mohammad Beigi, Masoome Khalife, Francisco Pan-Montojo

Publikováno v: The Protein Journal. 34:291-303

Aggregated alpha-synuclein (α-SYN) is the major component of Lewy bodies and Lewy neurites, two of the pathological hallmarks of Parkinson's disease (PD). Aggregation of α-SYN leads to toxic species involved in the degeneration of dopaminergic neur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1020d838f7f2a5000f4df3159c2d8725
https://doi.org/10.1007/s10930-015-9625-y

Neurotoxicity of pre-incubated alpha-synuclein with neutral nanoliposomes on PC12 and SHSY5Y cell lines

Autor: Farhang Aliakbari, Ali Akbar Saboury, Hassan Bardania, Dina Morshedi, Amir Tayaranian Marvian, Abbas Ali Vafaei, Ali Akbar Shabani, Hadieh Alsadat Eslampanah Seyedi, Seyed Abbas Shojaosadati, Mahour Nassoti, Hossein Mohammad-Beigi, Gunna Christiansen

Publikováno v: Aliakbari, F, Shabani, A A, Bardania, H, Seyedi, H A E, Mohammad-Beigie, H, Marvian, A T, Nasouti, M, Vafaei, A A, Shojaosadati, S A, Saboury, A A, Christiansen, G & Morshedi, D 2017, ' Neurotoxicity of pre-incubated alpha-synuclein with neutral nanoliposomes on PC12 and SHSY5Y cell lines ', Scientia Iranica: international journal of science & technology, vol. 24, no. 6, pp. 3542-3553 . https://doi.org/10.24200/sci.2017.4419

Alpha-synuclein (α-Syn) is an abundant protein in the brain with high tendency to convert into toxic aggregated forms that are involved in neurons degeneration in Parkinson's patients (PD). The conversion of α-Syn toward toxic aggregates may associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50daaed7d57911c5eda830b472514bf1
https://doi.org/10.24200/sci.2017.4419

Gallic acid loaded onto polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA-GA NPs) stabilizes α-synuclein in the unfolded conformation and inhibits aggregation

Autor: Hossein Mohammad-Beigi, Jannik Nedergaard Pedersen, Gunna Christiansen, Daniel E. Otzen, Amir Tayaranian Marvian, Seyed Abbas Shojaosadati, Dina Morshedi, Farhang Aliakbari, Jan Skov Pedersen

Publikováno v: Mohammad-Beigi, H, Morshedi, D, Shojaosadati, S A, Pedersen, J N, Marvian, A T, Aliakbari, F, Christiansen, G, Pedersen, J S & Otzen, D E 2016, ' Gallic acid loaded onto polyethylenimine-coated human serum albumin nanoparticles (PEI-HSA-GA NPs) stabilizes α-synuclein in the unfolded conformation and inhibits aggregation ', RSC Advances, vol. 6, no. 88, pp. 85312-85323 . https://doi.org/10.1039/c6ra08502d

The aggregation of the 140-residue protein α-synuclein (αSN) plays a major role in the pathogenesis of different neurodegenerative disorders such as Parkinson's Disease (PD). Previous reports indicated that the antioxidant gallic acid (GA) can inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1d06feffd93a1910f48a302f3c41f5
https://pure.au.dk/portal/da/publications/gallic-acid-loaded-onto-polyethyleniminecoated-human-serum-albumin-nanoparticles-peihsaga-nps-stabilizes-synuclein-in-the-unfolded-conformation-and-inhibits-aggregation(02372366-b8f3-4648-b1e6-bf014e8c2f6f).html