Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Amir Sapir"'
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100710- (2021)
Summary: This protocol describes the culturing of the nematode Caenorhabditis elegans (C. elegans) in a sterol-defined experimental system and the subsequent quantitative analysis of C. elegans sterols through gas chromatography-mass spectrometry. Al
Externí odkaz:
https://doaj.org/article/b6663520a2fc4032acc6fba42d83e837
Autor:
Amir Sapir
Publikováno v:
Communicative & Integrative Biology, Vol 14, Iss 1, Pp 24-26 (2021)
Extreme environments constitute the largest habitat on earth, but our understanding of life in such environments is rudimentary. The hostility of extreme environments such as the deep sea, earth’s crust, and toxic lakes limits the sampling, culturi
Externí odkaz:
https://doaj.org/article/97a1a6bc47774ec8a5123a4baeb81f89
Publikováno v:
Molecular Metabolism, Vol 39, Iss , Pp - (2020)
Objective: Statins are a group of medications that reduce cholesterol synthesis by inhibiting the activity of HMG-CoA reductase, a key enzyme in the mevalonate pathway. The clinical use of statins to lower excess cholesterol levels has revolutionized
Externí odkaz:
https://doaj.org/article/84664c67443e40b7afb8a7ba45bbb0c7
Autor:
Amir Sapir
Publikováno v:
Biomolecules, Vol 10, Iss 8, p 1154 (2020)
One of the basic building blocks of all life forms are lipids—biomolecules that dissolve in nonpolar organic solvents but not in water. Lipids have numerous structural, metabolic, and regulative functions in health and disease; thus, complex networ
Externí odkaz:
https://doaj.org/article/c1ce52f2f59e4586bcb1693d1242d5fb
Publikováno v:
Numerical Algorithms. 86:515-535
In this paper, we define s-nonstationary iterative process and obtain its properties. We prove, that for any one-point iterative process without memory, there exists an s-nonstationary process of the same order, but of higher efficiency by the criter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::178c21e94867cc6e04fa9226082c25b4
https://doi.org/10.1007/s11075-020-00899-5
https://doi.org/10.1007/s11075-020-00899-5
Autor:
Ron Lebedev, Irina Langier Goncalves, Benjamin Trabelcy, Yoram Gerchman, Shamsuzzama, Amir Sapir
Publikováno v:
Current biology : CB. 30(15)
Summary Cholesterol is one of the hallmarks of animals. In vertebrates, the cholesterol synthesis pathway (CSP) is the primary source of cholesterol that has numerous structural and regulative roles [ 1 ]. Nevertheless, the few invertebrates tested f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb006d2ee76a010fff4bbfbf40285f4
https://pubmed.ncbi.nlm.nih.gov/32750350
https://pubmed.ncbi.nlm.nih.gov/32750350
Publikováno v:
Genetics. 209:457-473
The mevalonate pathway is the primary target of the cholesterol-lowering drugs statins, some of the most widely prescribed medicines of all time. The pathway’s enzymes not only catalyze the synthesis of cholesterol but also of diverse metabolites s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f199ebc76c96db9144aff519acea145a
https://doi.org/10.1534/genetics.118.300863
https://doi.org/10.1534/genetics.118.300863
Publikováno v:
Applied Mathematics Letters. 66:40-46
In this paper we prove that, among all one-point iterative processes without memory of order p , the most efficient processes are of order p = 3 . Moreover, the computational efficiency of one-point iterative processes without memory decreases to 1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::514beda679a31b6ccda9b18a84c5163f
https://doi.org/10.1016/j.aml.2016.11.006
https://doi.org/10.1016/j.aml.2016.11.006
Autor:
Pei-Yin Shih, James Siho Lee, Amir Sapir, Andre Pires-daSilva, Jean M. Badroos, Elizabeth Goetz, Natsumi Kanzaki, Paul W. Sternberg, Ryoji Shinya
Extremophiles have much to reveal about the biology of resilience, yet their study is limited by sampling and culturing difficulties [1, 2, 3]. The broad success and small size of nematodes make them advantageous for tackling these problems [4, 5, 6]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0c3a7401296ecf98e65786e3176e45
https://resolver.caltech.edu/CaltechAUTHORS:20190926-092428868
https://resolver.caltech.edu/CaltechAUTHORS:20190926-092428868
Publikováno v:
Applied Numerical Mathematics. 110:148-158
This paper presents a class of stationary iterative processes with convergence order equal to the growth rate of generalized Fibonacci sequences. We prove that the informational and computational efficiency of the processes of our class tends to 2 fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6cfee3aa5c123df20620ad4db604173
https://doi.org/10.1016/j.apnum.2016.08.012
https://doi.org/10.1016/j.apnum.2016.08.012