Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Amir A Saei"'
Autor:
Jaime James, Yifei Chen, Clara M Hernandez, Florian Forster, Markus Dagnell, Qing Cheng, Amir A Saei, Hassan Gharibi, Gonzalo Fernandez Lahore, Annika Åstrand, Rajneesh Malhotra, Bernard Malissen, Roman A Zubarev, Elias SJ Arnér, Rikard Holmdahl
Publikováno v:
eLife, Vol 11 (2022)
Chronic autoimmune diseases are associated with mutations in PTPN22, a modifier of T cell receptor (TCR) signaling. As with all protein tyrosine phosphatases, the activity of PTPN22 is redox regulated, but if or how such regulation can modulate infla
Externí odkaz:
https://doaj.org/article/e84e04b732424594be1fff342674675b
Autor:
Amir A. Saei, Albin Lundin, Hezheng Lyu, Hassan Gharibi, Huqiao Luo, Jaakko Teppo, Xuepei Zhang, Massimiliano Gaetani, Ákos Végvári, Rikard Holmdahl, Steven P. Gygi, Roman A. Zubarev
Publikováno v:
Advanced Science, Vol 11, Iss 38, Pp n/a-n/a (2024)
Abstract Multifaceted interrogation of the proteome deepens the system‐wide understanding of biological systems; however, mapping the redox changes in the proteome has so far been significantly more challenging than expression and solubility/stabil
Externí odkaz:
https://doaj.org/article/4114f1d8a32a4ad2bd9642d81ff562bc
Autor:
Hassan Gharibi, Ali Akbar Ashkarran, Maryam Jafari, Elizabeth Voke, Markita P. Landry, Amir Ata Saei, Morteza Mahmoudi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract Protein corona, a layer of biomolecules primarily comprising proteins, forms dynamically on nanoparticles in biological fluids and is crucial for predicting nanomedicine safety and efficacy. The protein composition of the corona layer is typ
Externí odkaz:
https://doaj.org/article/b8a847a057ec49579c77e91fe925d12f
Autor:
Ali Akbar Ashkarran, Hassan Gharibi, Elizabeth Voke, Markita P. Landry, Amir Ata Saei, Morteza Mahmoudi
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Analysis of the protein corona formed around nanoparticles is important for multiple applications in nanomedicine, the methods used at core facilities used for analysis can impact the results. Here, the authors report on a study into the variability
Externí odkaz:
https://doaj.org/article/c664b595e4a64b9882a7f23582e7ce16
Autor:
Huqiao Luo, Vilma Urbonaviciute, Amir Ata Saei, Hezheng Lyu, Massimiliano Gaetani, Ákos Végvári, Yanpeng Li, Roman A. Zubarev, Rikard Holmdahl
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Low capacity to produce ROS because of mutations in neutrophil cytosolic factor 1 (NCF1/p47phox), a component of NADPH oxidase 2 (NOX2) complex, is strongly associated with systemic lupus erythematosus in both humans and mouse models. Here, we aimed
Externí odkaz:
https://doaj.org/article/1c3eb6f9eb03498b89fd3339d928583e
Autor:
Amir Ata Saei, Hassan Gharibi, Hezheng Lyu, Brady Nilsson, Maryam Jafari, Hans Von Holst, Roman A. Zubarev
Publikováno v:
Molecules, Vol 28, Iss 19, p 6768 (2023)
We investigated the immediate molecular consequences of traumatic brain injuries (TBIs) using a novel proteomics approach. We simulated TBIs using an innovative laboratory apparatus that employed a 5.1 kg dummy head that held neuronal cells and gener
Externí odkaz:
https://doaj.org/article/049e4a2adf1c4332b441c443b8cbe952
Autor:
Pierre Sabatier, Christian M. Beusch, Amir A. Saei, Mike Aoun, Noah Moruzzi, Ana Coelho, Niels Leijten, Magnus Nordenskjöld, Patrick Micke, Diana Maltseva, Alexander G. Tonevitsky, Vincent Millischer, J. Carlos Villaescusa, Sandeep Kadekar, Massimiliano Gaetani, Kamilya Altynbekova, Alexander Kel, Per-Olof Berggren, Oscar Simonson, Karl-Henrik Grinnemo, Rikard Holmdahl, Sergey Rodin, Roman A. Zubarev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
To characterize molecular changes during cell type transitions, the authors develop a method to simultaneously measure protein expression and thermal stability changes. They apply this approach to study differences between human pluripotent stem cell
Externí odkaz:
https://doaj.org/article/ea00b3040ab748c68e25909b2a8c2546
Autor:
Amir Ata Saei, Christian M. Beusch, Pierre Sabatier, Juan Astorga Wells, Hassan Gharibi, Zhaowei Meng, Alexey Chernobrovkin, Sergey Rodin, Katja Näreoja, Ann-Gerd Thorsell, Tobias Karlberg, Qing Cheng, Susanna L. Lundström, Massimiliano Gaetani, Ákos Végvári, Elias S. J. Arnér, Herwig Schüler, Roman A. Zubarev
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The global identification of enzyme substrates is still challenging. Here, the authors develop a method based on proteome-wide thermal shift assays to discover enzyme substrates directly from cell lysates, identifying known and novel oxidoreductase,
Externí odkaz:
https://doaj.org/article/565c329cae24403687890498fa03809d
Autor:
Amir Ata Saei, Christian Michel Beusch, Alexey Chernobrovkin, Pierre Sabatier, Bo Zhang, Ülkü Güler Tokat, Eleni Stergiou, Massimiliano Gaetani, Ákos Végvári, Roman A. Zubarev
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Anticancer drugs often have widespread effects on the cellular proteome. Here, the authors generate a proteome signature library of drug-treated cancer cell lines and develop a software tool to deconvolute drug targets and gain insights into their me
Externí odkaz:
https://doaj.org/article/ad0814e6df26497b89b780d2b504f842
Autor:
Mohammad J. Hajipour, Amir Ata Saei, Edward D. Walker, Brian Conley, Yadollah Omidi, Ki‐Bum Lee, Morteza Mahmoudi
Publikováno v:
Advanced Science, Vol 8, Iss 21, Pp n/a-n/a (2021)
Abstract The emergence of nanotechnology has created unprecedented hopes for addressing several unmet industrial and clinical issues, including the growing threat so‐termed “antibiotic resistance” in medicine. Over the last decade, nanotechnolo
Externí odkaz:
https://doaj.org/article/760fa47df7904e82be5e31f2cbe292c8