Výsledky vyhledávání - "Aminophenols/therapeutic use"

The impact of FDA and EMA regulatory decision-making process on the access to CFTR modulators for the treatment of cystic fibrosis

Autor: Costa, Enrico, Girotti, Silvia, Pauro, Francesca, Leufkens, Hubert G.M., Cipolli, Marco, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

Publikováno v: Orphanet Journal of Rare Diseases, 17(1), 1. BioMed Central

Background Over the past decade, a new class of drugs called CFTR (cystic fibrosis transmembrane conductance regulator) modulators have shown to be able to improve clinical outcomes in patient with Cystic Fibrosis. In this analysis, we have extensive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8bbc4a71f04a25379f615d0f8b7a11
https://doi.org/10.1186/s13023-022-02350-5

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Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

Autor: Daniel Peckham, Paul Whitaker, Anil Mehta, Sinisa Savic, Michael F. McDermott, T. Scambler, J. Holbrook, Christine Etherington, Ian Clifton, Heledd H. Jarosz-Griffiths, Samuel Lara-Reyna, Giulia Spoletini, C. Wong, Fabio Martinon

Publikováno v: eLife
eLife, Vol 9 (2020)
eLife, vol. 9, pp. e54556

Previously, we showed that serum and monocytes from patients with CF exhibit an enhanced NLRP3-inflammasome signature with increased IL-18, IL-1β, caspase-1 activity and ASC speck release (Scambler et al. eLife 2019). Here we show that CFTR modulato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56c3b19820b0ec649de1acb486b5ee6
https://eprints.whiterose.ac.uk/158253/7/elife-54556-v2.pdf

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