Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Aminocamptothecin"'
Publikováno v:
AAPS PharmSciTech. 15:223-229
The present manuscript provides a detailed physicochemical and thermodynamic characterization of 9-aminocamptothecin (9AC) which can be used as a tool to develop novel formulation strategies for optimum pharmacological activity. The pKa of 9AC was de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d073e66e901c3854e2b54f400fef93f7
https://doi.org/10.1208/s12249-013-0046-y
https://doi.org/10.1208/s12249-013-0046-y
Publikováno v:
European Journal of Pharmaceutical Sciences. 49:858-863
As a first step towards improving the aqueous stability of 9-aminocamptothecin (9AC), a detailed kinetic and thermodynamic investigation of the hydrolysis reaction of 9AC was carried out, using a first derivative absorption spectrophotometry techniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09d4fc05c5b0a1b54dff0e81f2af68ff
https://doi.org/10.1016/j.ejps.2013.06.005
https://doi.org/10.1016/j.ejps.2013.06.005
Publikováno v:
Pharmaceutical Research. 25:218-226
To quantitate and predict colon-specific 9-aminocamptothecin (9-AC) release from the N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-9-AC conjugate and its absorption behavior after oral administration in rats.Drug distribution in the gastrointest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e0396af1e719a471df3cbee781de79b
https://doi.org/10.1007/s11095-007-9465-3
https://doi.org/10.1007/s11095-007-9465-3
Publikováno v:
Journal of Controlled Release. 117:179-185
A water soluble N -(2-hydroxypropyl)methacrylamide (HPMA) copolymer–9-aminocamptothecin (9-AC) conjugate was designed for oral colon-specific drug delivery in the treatment of colon cancer. Comparative studies between the polymer conjugate and free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51587e4681b0a25d5d6fdd7459a9078
https://doi.org/10.1016/j.jconrel.2006.10.024
https://doi.org/10.1016/j.jconrel.2006.10.024
Autor:
Ramesh K. Ramanathan, Merrill J. Egorin, Lauren J. Maruca, William C. Zamboni, Robert A. Parise, Sharon Marsh, Sandra Strychor, Todd A. Davis, Howard L. McLeod, Laura L. Jung, Sridhar Mani, Cristi R. King, Douglas M. Potter
Publikováno v:
Investigational New Drugs. 24:393-401
Purpose: The source of the pharmacokinetic variability of 9-nitrocamptothecin (9NC) and its 9-aminocamptothecin (9AC) metabolite is unknown. ATP-binding cassette (ABC) transporters have been reported to modulate camptothecin analogues, are associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0afd338ebdccd1c7e1f79bc4d09bbac
https://doi.org/10.1007/s10637-006-6335-5
https://doi.org/10.1007/s10637-006-6335-5
Publikováno v:
Molecular Cancer Therapeutics. 5:739-745
The topoisomerase I (top1)–targeted camptothecin class of anticancer drugs is important in the treatment of several types of cancers. This class of drug inhibits the top1 enzyme during its catalytic DNA relaxation cycle, stabilizing the transient c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d26a515836b15bb45c17d9f15c348b
https://doi.org/10.1158/1535-7163.mct-05-0377
https://doi.org/10.1158/1535-7163.mct-05-0377
Autor:
Rebecca R. Thomas, Chris H. Takimoto
Publikováno v:
Annals of the New York Academy of Sciences. 922:224-236
9-Aminocamptothecin (9-AC) is a topoisomerase I-targeting agent first synthesized by Wani and Wall in 1986. Because of its potent in vitro effects and promising preclinical activity in colorectal cancer animal models, it was designated a high-priorit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c607efc37b0ae369ed12f3289deadaf
https://doi.org/10.1111/j.1749-6632.2000.tb07041.x
https://doi.org/10.1111/j.1749-6632.2000.tb07041.x
Autor:
Andrea Downey, Joan Sorich, Heather Wasserstrom, Milan Potmesil, Howard S. Hochster, Leonard Liebes, Gila Hornreich, Franco M. Muggia, Anne Hamilton
Publikováno v:
Annals of the New York Academy of Sciences. 922:178-187
The i.p. administration of topoisomerase I (Topo I) inhibitors has a pharmacologic advantage over intravenous application, including preservation of the biologically active lactone form. In our ongoing study, patients have received 9-amino-20(S)-camp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8df6323a1587a16fad4f79e193cd93
https://doi.org/10.1111/j.1749-6632.2000.tb07036.x
https://doi.org/10.1111/j.1749-6632.2000.tb07036.x
Publikováno v:
Journal of Controlled Release. 110:323-331
N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer–9-aminocamptothecin (9-AC) conjugate for oral colon-specific drug delivery was designed, synthesized, and characterized. The drug, 9-AC, was attached to the polymer carrier via a spacer containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49fc04da8632413c9446d480f9ec8699
https://doi.org/10.1016/j.jconrel.2005.10.004
https://doi.org/10.1016/j.jconrel.2005.10.004
Autor:
Robert A. Parise, Merrill J. Egorin, Sridhar Mani, Tahir Iqbal, Trisha V. W. Repinski, William C. Zamboni, Sanjay Goel, Sandra Strychor
Publikováno v:
Cancer Chemotherapy and Pharmacology. 57:631-639
9-Nitrocamptothecin (9NC) is an orally administered camptothecin analogue that has completed phase III trials for pancreatic cancer. In biological matrices, camptothecin analogues exist in equilibrium between the active-lactone (LAC) and inactive-hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b422bac403c1b1cf8214a82b9b0db1
https://doi.org/10.1007/s00280-005-0084-6
https://doi.org/10.1007/s00280-005-0084-6