Zobrazeno 1 - 10
of 4 258
pro vyhledávání: '"Aminoacyl-tRNA synthetase"'
Autor:
Lei Lei, Zachary Frome Burton
Publikováno v:
DNA, Vol 4, Iss 3, Pp 252-275 (2024)
The three 31 nucleotide minihelix tRNA evolution theorem describes the evolution of type I and type II tRNAs to the last nucleotide. In databases, type I and type II tRNA V loops (V for variable) were improperly aligned, but alignment based on the th
Externí odkaz:
https://doaj.org/article/8b97f6e9330541dd971cbf7fae8a85f6
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-11 (2024)
Abstract Background Anti-Ro-52 antibodies have been associated with interstitial lung disease (ILD) in various autoimmune diseases. However, their role in ILD among patients with idiopathic inflammatory myopathies (IIMs) is relatively underexplored.
Externí odkaz:
https://doaj.org/article/2b80548ec4814d7988bce52699dade94
Autor:
Tsuneo Sasai, Yuki Ishikawa, Ran Nakashima, Takuya Isayama, Kiminobu Tanizawa, Tomohiro Handa, Mirei Shirakashi, Ryosuke Hiwa, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Hajime Yoshifuji, Tsuneyo Mimori, Akio Morinobu
Publikováno v:
Immunological Medicine, Vol 47, Iss 3, Pp 166-175 (2024)
Anti-aminoacyl-tRNA synthetase (ARS) antibodies are myositis-specific antibodies associated with anti-synthetase syndrome (ASSD). Some patients are positive for anti-ARS antibodies on enzyme-linked immunosorbent assay (ELISA) but negative on RNA-immu
Externí odkaz:
https://doaj.org/article/0e54cf86633747cca51432c1af8c6c16
Autor:
Ević Valentina, Rokov-Plavec Jasmina
Publikováno v:
Arhiv za Higijenu Rada i Toksikologiju, Vol 75, Iss 2, Pp 147-154 (2024)
Mistakes in translation are mostly associated with toxic effects in the cell due to the production of functionally aberrant and misfolded proteins. However, under certain circumstances mistranslation can have beneficial effects and enable cells to pr
Externí odkaz:
https://doaj.org/article/3ec1128aba6541018aed4d412e053b0b
Publikováno v:
AMB Express, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Genetic code expansion involves introducing non-canonical amino acids (ncAAs) with unique functional groups into proteins to broaden their applications. Orthogonal aminoacyl tRNA synthetase (aaRS), essential for genetic code expansion, facil
Externí odkaz:
https://doaj.org/article/d7c7c6a369c54650baaa05f04d7c76be
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
Faithful mRNA decoding depends on the accuracy of aminoacyl-tRNA synthetases (ARSs). Aminoacyl-tRNA proofreading mechanisms have been well-described in bacteria, humans, and plants. However, our knowledge of translational fidelity in protozoans is li
Externí odkaz:
https://doaj.org/article/7fbec45995bd41548fc0ce6ac169ed5b
Autor:
Elena R. Rhymes, Rebecca L. Simkin, Ji Qu, David Villarroel-Campos, Sunaina Surana, Yao Tong, Ryan Shapiro, Robert W. Burgess, Xiang-Lei Yang, Giampietro Schiavo, James N. Sleigh
Publikováno v:
Neurobiology of Disease, Vol 195, Iss , Pp 106501- (2024)
Charcot-Marie-Tooth disease (CMT) is a genetic peripheral neuropathy caused by mutations in many functionally diverse genes. The aminoacyl-tRNA synthetase (ARS) enzymes, which transfer amino acids to partner tRNAs for protein synthesis, represent the
Externí odkaz:
https://doaj.org/article/6a2c5beddc18443097b6a65f58d65c80
Autor:
Sharon Bright Amanya, Damilola Oyewole-Said, Keenan J. Ernste, Nalini Bisht, Arnav Murthy, Jonathan Vazquez-Perez, Vanaja Konduri, William K. Decker
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Over the course of evolution, many proteins have undergone adaptive structural changes to meet the increasing homeostatic regulatory demands of multicellularity. Aminoacyl tRNA synthetases (aaRS), enzymes that catalyze the attachment of each amino ac
Externí odkaz:
https://doaj.org/article/8a998717502f4742a1fecda4823f8b39
Autor:
Masaru Takeshita, Katsuya Suzuki, Maho Nakazawa, Hirofumi Kamata, Makoto Ishii, Yoshitaka Oyamada, Hisaji Oshima, Satoshi Usuda, Kazuyuki Tsunoda, Tsutomu Takeuchi
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Interstitial lung disease is a common complication of anti-synthetase syndrome (ASS), and lymphocytic infiltration is often observed in the lesion. We have recently reported that disease-specific autoantibodies are produced by infiltrating lymphocyte
Externí odkaz:
https://doaj.org/article/d7f67e22fa9f430da443f477468e3e06
Publikováno v:
BMC Immunology, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Background Patients with idiopathic inflammatory myopathy (IIM) often express a different type of myositis-specific autoantibodies (MSAs), each associated with different clinical symptoms. Understanding the immunopathogenesis of various IIM
Externí odkaz:
https://doaj.org/article/cfe1f60d52184a45860c6f9520a59638