Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amine Meliani"'
Autor:
Amine Meliani, Florence Boisgerault, Romain Hardet, Solenne Marmier, Fanny Collaud, Giuseppe Ronzitti, Christian Leborgne, Helena Costa Verdera, Marcelo Simon Sola, Severine Charles, Alban Vignaud, Laetitia van Wittenberghe, Giorgia Manni, Olivier Christophe, Francesca Fallarino, Christopher Roy, Alicia Michaud, Petr Ilyinskii, Takashi Kei Kishimoto, Federico Mingozzi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Immunogenicity of AAV vectors renders repeated AAV dosing ineffective. Here the authors show that coadministration of nanoparticle-encapsulated rapamycin overcomes AAV immunogenicity through Treg induction, enabling efficient AAV redosing in mice and
Externí odkaz:
https://doaj.org/article/8c201057906f4f2d8d990ffb8e12cbae
Autor:
Amine Meliani, Florence Boisgerault, Zachary Fitzpatrick, Solenne Marmier, Christian Leborgne, Fanny Collaud, Marcelo Simon Sola, Severine Charles, Giuseppe Ronzitti, Alban Vignaud, Laetitia van Wittenberghe, Beatrice Marolleau, Fabienne Jouen, Sisareuth Tan, Olivier Boyer, Olivier Christophe, Alain R. Brisson, Casey A. Maguire, Federico Mingozzi
Publikováno v:
Blood Advances, Vol 1, Iss 23, Pp 2019-2031 (2017)
Abstract: Results from clinical trials of liver gene transfer for hemophilia demonstrate the potential of the adeno-associated virus (AAV) vector platform. However, to achieve therapeutic transgene expression, in some cases high vector doses are requ
Externí odkaz:
https://doaj.org/article/302c51191d2d4ae38857d80e959d437b
Autor:
Jérémie Martinet, Gwladys Bourdenet, Amine Meliani, Laetitia Jean, Sahil Adriouch, José Cohen, Federico Mingozzi, Olivier Boyer
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Background: Gene therapy is a promising treatment option for hemophilia and other protein deficiencies. However, immune responses against the transgene product represent an obstacle to safe and effective gene therapy, urging for the implementation of
Externí odkaz:
https://doaj.org/article/7f73db0594e1439bacc255be08ad6e86
Autor:
Casey A. Maguire, Federico Mingozzi, Benjamin P. Kleinstiver, James J. Moon, Killian S. Hanlon, Amine Meliani, Jeya-shree Natasan, Cort B. Breuer, Adrienn Volak
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.4544. ⟨10.1038/s41598-020-61518-w⟩
Scientific Reports, 2020, 10 (1), pp.4544. ⟨10.1038/s41598-020-61518-w⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.4544. ⟨10.1038/s41598-020-61518-w⟩
Scientific Reports, 2020, 10 (1), pp.4544. ⟨10.1038/s41598-020-61518-w⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Ex-vivo gene therapy using stem cells or T cells transduced by retroviral or lentiviral vectors has shown remarkable efficacy in the treatment of immunodeficiencies and cancer. However, the process is expensive, technically challenging, and not readi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b77a37f8b5936602f5fbae03465d3b8
https://www.hal.inserm.fr/inserm-02511253/file/s41598-020-61518-w.pdf
https://www.hal.inserm.fr/inserm-02511253/file/s41598-020-61518-w.pdf
Autor:
Florence Boisgerault, Federico Mingozzi, Romain Hardet, Helena Costa Verdera, Giuseppe Ronzitti, Alicia M. Michaud, Fanny Collaud, Amine Meliani, Giorgia Manni, Severine Charles, Alban Vignaud, Christian Leborgne, Petr Ilyinskii, Takashi Kei Kishimoto, Marcelo Simon Sola, Francesca Fallarino, Olivier D. Christophe, Solenne Marmier, Christopher J. Roy, Laetitia van Wittenberghe
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, 2018, 9 (1), pp.4098. ⟨10.1038/s41467-018-06621-3⟩
Gene therapy mediated by recombinant adeno-associated virus (AAV) vectors is a promising treatment for systemic monogenic diseases. However, vector immunogenicity represents a major limitation to gene transfer with AAV vectors, particularly for vecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e609f78e07de4ba083e8423956027be
http://hdl.handle.net/11391/1439292
http://hdl.handle.net/11391/1439292
Autor:
Christian Leborgne, Béatrice Marolleau, Alain Brisson, Casey A. Maguire, Federico Mingozzi, Fabienne Jouen, Laetitia van Wittenberghe, Alban Vignaud, Florence Boisgerault, Olivier D. Christophe, Fanny Collaud, Solenne Marmier, Giuseppe Ronzitti, Olivier Boyer, Zachary Fitzpatrick, Sisareuth Tan, Amine Meliani, Marcelo Simon Sola, Severine Charles
Publikováno v:
Blood Advances
Blood Advances, The American Society of Hematology, 2017, 1 (23), pp.2019-2031. ⟨10.1182/bloodadvances.2017010181⟩
Blood Advances, 2017, 1 (23), pp.2019-2031. ⟨10.1182/bloodadvances.2017010181⟩
Blood Advances, The American Society of Hematology, 2017, 1 (23), pp.2019-2031. ⟨10.1182/bloodadvances.2017010181⟩
Blood Advances, 2017, 1 (23), pp.2019-2031. ⟨10.1182/bloodadvances.2017010181⟩
Results from clinical trials of liver gene transfer for hemophilia demonstrate the potential of the adeno-associated virus (AAV) vector platform. However, to achieve therapeutic transgene expression, in some cases high vector doses are required, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2526ac2de33b1e6b5de9af723d344245
https://hal.archives-ouvertes.fr/hal-02377508
https://hal.archives-ouvertes.fr/hal-02377508
Autor:
Federico Mingozzi, Sahil Adriouch, José Cohen, Jérémie Martinet, Laetitia Jean, Olivier Boyer, Amine Meliani, Gwladys Bourdenet
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2016, 7, pp.360. ⟨10.3389/fimmu.2016.00360⟩
Frontiers in Immunology, Frontiers, 2016, 7, ⟨10.3389/fimmu.2016.00360⟩
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology, 2016, 7, pp.360. ⟨10.3389/fimmu.2016.00360⟩
Frontiers in Immunology, Frontiers, 2016, 7, pp.360. ⟨10.3389/fimmu.2016.00360⟩
Frontiers in Immunology, Frontiers, 2016, 7, ⟨10.3389/fimmu.2016.00360⟩
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology, 2016, 7, pp.360. ⟨10.3389/fimmu.2016.00360⟩
International audience; Background: Gene therapy is a promising treatment option for hemophilia and other protein deficiencies. However, immune responses against the transgene product represent an obstacle to safe and effective gene therapy, urging f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03270f59088ef41cc08dfdcf49bc5b60
https://hal.sorbonne-universite.fr/hal-01378432/document
https://hal.sorbonne-universite.fr/hal-01378432/document
Autor:
Sabrina Triffault, Laurence Jeanson-Leh, Federico Mingozzi, Philippe Veron, Christian Leborgne, Amine Meliani
Publikováno v:
Hum Gene Ther Methods
Hum Gene Ther Methods, 2015, 26 (2), pp.45-53. ⟨10.1089/hgtb.2015.037⟩
Human Gene Therapy Methods
Hum Gene Ther Methods, 2015, 26 (2), pp.45-53. ⟨10.1089/hgtb.2015.037⟩
Human Gene Therapy Methods
International audience; Adeno-associated virus (AAV) vectors are a platform of choice for in vivo gene transfer applications. However, neutralizing antibodies (NAb) to AAV can be found in humans and some animal species as a result of exposure to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b7ca74c8c5fcbe4c43a6f28205c0ec
https://hal.science/hal-02880998
https://hal.science/hal-02880998
Autor:
Florence Boisgerault, Fanny Collaud, Amine Meliani, Casey A. Maguire, Zachary Fitzpatrick, Giuseppe Ronzitti, Federico Mingozzi, Severine Charles
Publikováno v:
Molecular Therapy. 24:S235-S236
Adeno-associated virus (AAV) based vectors are ideal tools for in vivo gene transfer. The excellent safety profile and the highly efficient targeting of hepatocytes in vivo have been demonstrated in both preclinical studies and clinical trials. Altho
Autor:
Olivier D. Christophe, Janka Matrai, Marinee Chuah, Jessica Willems, Pieter De Bleser, Melvin Y Rincon, Bing Yan, Caroline Le Guiner, Véronique Blouin, Mario Di Matteo, Gwladys Gernoux, Philippe Moullier, Oumeya Adjali, Inge Petrus, Hanneke Evens, Nisha Nair, Ermira Samara-Kuko, Thierry VandenDriessche, Abel Acosta-Sanchez, Amine Meliani, Federico Mingozzi, Ghislaine Cherel
Publikováno v:
Molecular Therapy
Molecular Therapy, Cell Press, 2014, 22 (9), pp.1605-13. ⟨10.1038/mt.2014.114⟩
MOLECULAR THERAPY
Molecular Therapy, 2014, 22 (9), pp.1605-13. ⟨10.1038/mt.2014.114⟩
Molecular Therapy, Cell Press, 2014, 22 (9), pp.1605-13. ⟨10.1038/mt.2014.114⟩
MOLECULAR THERAPY
Molecular Therapy, 2014, 22 (9), pp.1605-13. ⟨10.1038/mt.2014.114⟩
International audience; The robustness and safety of liver-directed gene therapy can be substantially improved by enhancing expression of the therapeutic transgene in the liver. To achieve this, we developed a new approach of rational in silico vecto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1f65dbbfc5886c60eb312eef988d094
https://hal.archives-ouvertes.fr/hal-02881197
https://hal.archives-ouvertes.fr/hal-02881197