ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer

Autor: Nakisa Tabrizian, Shaghayegh Nouruzi, Cassandra Jingjing Cui, Maxim Kobelev, Takeshi Namekawa, Ishana Lodhia, Amina Talal, Olena Sivak, Dwaipayan Ganguli, Amina Zoubeidi

Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 112937- (2023)

Summary: Lineage plasticity is a form of therapy-induced drug resistance. In prostate cancer, androgen receptor (AR) pathway inhibitors potentially lead to the accretion of tumor relapse with loss of AR signaling and a shift from a luminal state to a

Externí odkaz: https://doaj.org/article/1783e6f100dc47309a0545ae19edabeb

An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer

Autor: Chiara Bostock, Dwaipayan Ganguli, David W. Goodrich, Soojin Kim, Amina Talal, Suzan Stelloo, Wilbert Zwart, Jennifer L. Bishop, Ladan Fazli, Marlous Hoogstraat, Henk G. van der Poel, Felix Y. Feng, Sahil Kumar, Meltem E. Omur, Himisha Beltran, Musaddeque Ahmed, Fatih Karaoğlanoğlu, Housheng Hansen He, Haojie Huang, Andries M. Bergman, Olena Sivak, Faraz Hach, Daksh Thaper, Martin E. Gleave, Takeshi Namekawa, Luke A. Selth, Amina Zoubeidi, Alastair H. Davies, Simon Linder, Wayne D. Tilley, Maxim Kobelev, Shaghayegh Nouruzi

Publikováno v: Nature Cell Biology. 23:1023-1034

Cancers adapt to increasingly potent targeted therapies by reprogramming their phenotype. Here we investigated such a phenomenon in prostate cancer, in which tumours can escape epithelial lineage confinement and transition to a high-plasticity state

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bf7dc549f2596c2bd670e3418ca4414
https://doi.org/10.1038/s41556-021-00743-5

Cross-Talk between CD14 and Complement Receptor 3 Promotes Phagocytosis of Mycobacteria: Regulation by Phosphatidylinositol 3-Kinase and Cytohesin-1

Autor: Khalid Sendide, James Lee, Zakaria Hmama, Neil E. Reiner, Amina Talal, Sylvain G. Bourgoin

Publikováno v: The Journal of Immunology. 174:4210-4219

The glycosylphosphatidyl anchored molecule CD14 to the monocyte membrane plays a prominent role in innate immunity, and the paradigms for CD14 selective signaling are beginning to be elucidated. In this study, transfected human monocytic cell line TH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79268416001b4780c4dd0384ec273b8
https://doi.org/10.4049/jimmunol.174.7.4210

Mycobacterium bovis Bacillus Calmette-Guérin Secreting Active Cathepsin S Stimulates Expression of Mature MHC Class II Molecules and Antigen Presentation in Human Macrophages

Autor: Ala-Eddine Deghmane, Amina Talal, Zakaria Hmama, Jim Sun, Karen Mak, Yossef Av-Gay, Hafid Soualhine

Publikováno v: Journal of Immunology
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2007, 179 (8), pp.5137-5145. ⟨10.4049/jimmunol.179.8.5137⟩
Scopus-Elsevier

A successful Th cell response to bacterial infections is induced by mature MHC class II molecules presenting specific Ag peptides on the surface of macrophages. In recent studies, we demonstrated that infection with the conventional vaccine Mycobacte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb73a88f99b7c9cd06cfecf1eb5f3afc
https://hal-pasteur.archives-ouvertes.fr/pasteur-03262238

Lipoamide dehydrogenase mediates retention of coronin-1 on BCG vacuoles, leading to arrest in phagosome maturation

Autor: Ala-Eddine, Deghmane, Hafid, Soualhine, Hafid, Soulhine, Horacio, Bach, Khalid, Sendide, Saotomo, Itoh, Andrea, Tam, Sanaa, Noubir, Amina, Talal, Raymond, Lo, Satoshi, Toyoshima, Yossef, Av-Gay, Zakaria, Hmama

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2007, 120 (16), pp.2796-2806. ⟨10.1242/jcs.006221⟩

International audience; Mycobacterium tuberculosis evades the innate antimicrobial defenses of macrophages by inhibiting the maturation of its phagosome to a bactericidal phagolysosome. Despite intense studies of the mycobacterial phagosome, the mech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95126dfb71624d618e78e1a3f7147fd4
https://doi.org/10.1242/jcs.022335