Výsledky vyhledávání - "Amina Metidji"

Akademický článek

Cell-intrinsic Aryl Hydrocarbon Receptor signalling is required for the resolution of injury-induced colonic stem cells

Autor: Kathleen Shah, Muralidhara Rao Maradana, M. Joaquina Delàs, Amina Metidji, Frederike Graelmann, Miriam Llorian, Probir Chakravarty, Ying Li, Mauro Tolaini, Michael Shapiro, Gavin Kelly, Chris Cheshire, Deendyal Bhurta, Sandip B. Bharate, Brigitta Stockinger

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Rapid intestinal regeneration after injury is critical to maintain barrier integrity and homeostasis, but must be tightly controlled to prevent tumorigenesis. Here they show that the aryl hydrocarbon receptor is required to terminate the regenerative

Externí odkaz: https://doaj.org/article/d87470825f124e199a008a818ff3399e

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Akademický článek

Type I interferon signaling attenuates regulatory T cell function in viral infection and in the tumor microenvironment.

Autor: Arunakumar Gangaplara, Craig Martens, Eric Dahlstrom, Amina Metidji, Ameya S Gokhale, Deborah D Glass, Maria Lopez-Ocasio, Rachel Baur, Kishore Kanakabandi, Stephen F Porcella, Ethan M Shevach

Publikováno v: PLoS Pathogens, Vol 14, Iss 4, p e1006985 (2018)

Regulatory T cells (Tregs) play a cardinal role in the immune system by suppressing detrimental autoimmune responses, but their role in acute, chronic infectious diseases and tumor microenvironment remains unclear. We recently demonstrated that IFN-�

Externí odkaz: https://doaj.org/article/352cb6df548545caacd04633bbe41048

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A Murine Model Harboring Cooperating DNMT3A and SF3B1 Mutations Phenocopies SF3B1 Driven Myelodysplastic Syndrome

Autor: Lashanale Wallace, Ana Leal-Cervantes, Amina Metidji, Jacquelyn Myers, Chandra Rolle, Heather Tillman, Esther A. Obeng

Publikováno v: Blood. 140:5862-5863

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f2b0e6401cfbca58bb549bf3e1c5ac9
https://doi.org/10.1182/blood-2022-170535

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Splicing factor deficits render hematopoietic stem and progenitor cells sensitive to STAT3 inhibition

Autor: Kathryn S. Potts, Rosannah C. Cameron, Amina Metidji, Noura Ghazale, LaShanale Wallace, Ana I. Leal-Cervantes, Reid Palumbo, Juan Martin Barajas, Varun Gupta, Srinivas Aluri, Kith Pradhan, Jacquelyn A. Myers, Mia McKinstry, Xiaoying Bai, Gaurav S. Choudhary, Aditi Shastri, Amit Verma, Esther A. Obeng, Teresa V. Bowman

Publikováno v: Cell Reports. 41:111825

Hematopoietic stem and progenitor cells (HSPCs) sustain lifelong hematopoiesis. Mutations of pre-mRNA splicing machinery, especially splicing factor 3b, subunit 1 (SF3B1), are early lesions found in malignancies arising from HSPC dysfunction. However

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f838f703d2ac341d0902023631c6bf5c
https://doi.org/10.1016/j.celrep.2022.111825

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3220 – SF3B1/DNMT3A CO-MUTATION MIMICS FEATURES OF SOLE SF3B1 OR DNMT3A MUTATION DEPENDING ON STRESS CONDITIONS

Autor: LaShanale Wallace, Ana Leal Cervantes, Amina Metidji, Jacquelyn Myers, Koral Campbell, Jordan Skorupa, Henry Fields, Chandra Rolle, Heather Tillman, Esther Obeng

Publikováno v: Experimental Hematology. 111:S154-S155

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b33cc16f37806b71423c0caa2301251c
https://doi.org/10.1016/j.exphem.2022.07.276

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Type I IFN signaling in T regulatory cells modulates chemokine production and myeloid derived suppressor cells trafficking during EAE

Autor: Eric Dahlstrom, Lydia Sykora, Ethan M. Shevach, Amina Metidji, Kishore Kanakabandi, Cihan Oguz, Kent D. Barbian, Shalini Tanwar

Publikováno v: J Autoimmun

Interferon-β has therapeutic efficacy in Multiple Sclerosis by reducing disease exacerbations and delaying relapses. Previous studies have suggested that the effects of type I IFN in Experimental Autoimmune Encephalomyelitis (EAE) in mice were targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f21a6af3d58a1bb316e02fd939c17c7
https://pubmed.ncbi.nlm.nih.gov/32709481

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The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells

Autor: Maximiliano G. Gutierrez, Mauro Tolaini, Gavin Kelly, Saeed Shoaie, Probir Chakravarty, Sara Omenetti, Brigitta Stockinger, Amina Metidji, Ying Li, Andrea Iseppon, Sunjae Lee, Claudio Bussi

Publikováno v: Immunity
Omenetti, S, Bussi, C, Metidji, A, Iseppon, A, Lee, S, Tolaini, M, Li, Y, Kelly, G, Chakravarty, P, Shoaie, S, G. Gutierrez, M & Stockinger, B 2019, ' The Intestine Harbors Functionally Distinct Homeostatic Tissue-Resident and Inflammatory Th17 Cells ', Immunity, vol. 51, no. 1, pp. 77-89.e6 . https://doi.org/10.1016/j.immuni.2019.05.004

Summary T helper 17 (Th17) cells are pathogenic in many inflammatory diseases, but also support the integrity of the intestinal barrier in a non-inflammatory manner. It is unclear what distinguishes inflammatory Th17 cells elicited by pathogens and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4501f074c90c483b88eb2abd33273a04
https://pubmed.ncbi.nlm.nih.gov/31229354

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