Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amina I. Shehu"'
Autor:
Amina I. Shehu, Xiaochao Ma
Publikováno v:
Liver Research, Vol 2, Iss 4, Pp 173-179 (2018)
The pregnane X receptor (PXR) is a ligand activated nuclear receptor that is highly expressed in the liver and regulates many cellular functions including drug metabolism, endobiotic metabolism, oxidative stress response, apoptosis, inflammation, cel
Externí odkaz:
https://doaj.org/article/61f7b219dbf64c47b57af5628fe35823
Publikováno v:
J Pharmacol Exp Ther
Dolutegravir (DTG) is a potent integrase inhibitor of human immunodeficiency virus. Because DTG is a substrate of the efflux transporter ABCG2 and ABCG2 is highly polymorphic, we asked whether dose adjustment of DTG is needed for ABCG2-deficient indi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674d1d9f808c055ef70831ba7d326127
https://doi.org/10.1124/jpet.119.264424
https://doi.org/10.1124/jpet.119.264424
Autor:
Jian Hua Li, Xiaochao Ma, Amina I. Shehu, Deborah McMahon, Frank J. Gonzalez, Junjie Zhu, Wen Xie, Jie Lu
Publikováno v:
Toxicol Sci
Liver-related diseases including drug-induced liver injury are becoming increasingly prominent in AIDS patients. Cobicistat (COBI) is the backbone of multiple regimens for antiretroviral therapy. The current work investigated the mechanisms of advers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a66fe3ce3a39ea25d303eb83f79ebb
https://europepmc.org/articles/PMC8081023/
https://europepmc.org/articles/PMC8081023/
Autor:
Deborah McMahon, Pengcheng Wang, Xiaochao Ma, Junjie Zhu, Jie Lu, Feng Li, Amina I. Shehu, Wen Xie
Publikováno v:
Biochemical Pharmacology. 158:174-184
Dolutegravir (DTG), a potent integrase inhibitor, is part of a recommended initial regimen for the treatment of human immunodeficiency virus (HIV). Prior reports demonstrated that the clearance of DTG was higher in current smokers than non-smokers, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80e668f464f4862c92ecc06f6c761009
https://doi.org/10.1016/j.bcp.2018.10.012
https://doi.org/10.1016/j.bcp.2018.10.012
Publikováno v:
Chemical Research in Toxicology. 31:548-555
Idelalisib (ILB) is a selective phosphatidylinositol-3-kinase delta inhibitor approved for the treatment of hematological malignancies. However, ILB frequently causes hepatotoxicity, and the exact mechanism remains unclear. The current study profiled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87d0dbbc03c2d19ebbb1cb672168840
https://doi.org/10.1021/acs.chemrestox.8b00023
https://doi.org/10.1021/acs.chemrestox.8b00023
Autor:
Xiao-bo Zhong, Amina I. Shehu, Pengcheng Wang, Denis M. Grant, Jie Lu, Rujuta Joshi, Kim S. Sugamori, Xiaochao Ma, Raman Venkataramanan
Publikováno v:
Biochemical Pharmacology. 145:218-225
Acetylation is the major metabolic pathway of isoniazid (INH) mediated by N-acetyltransferases (NATs). Previous reports suggest that slow acetylators have higher risks of INH hepatotoxicity than rapid acetylators, but the detailed mechanisms remain e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fdce780208a1f3c7dc1a9fb2a50bf7
https://doi.org/10.1016/j.bcp.2017.09.001
https://doi.org/10.1016/j.bcp.2017.09.001
Publikováno v:
Clinics in Liver Disease. 21:35-54
Drug-induced hepatotoxicity (DIH) is a significant cause of acute liver failure and liver transplantation. Diagnosis is challenging due to the idiosyncratic nature, its presentation in the form of other liver disease, and the lack of a definite diagn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274b24bd6e6fba5ccf5164e7120a744b
https://doi.org/10.1016/j.cld.2016.08.002
https://doi.org/10.1016/j.cld.2016.08.002
Autor:
Pengcheng Wang, Curtis D. Klaassen, Xiaochao Ma, Madhav Sachar, Amina I. Shehu, Ke Liu, Jing Chen, Frank J. Gonzalez, Karl E. Anderson, Junjie Zhu, Jie Lu, Wen Xie
Publikováno v:
Science Advances
The transporter ABCG2 determines phototoxicity and hepatotoxicity in erythropoietic protoporphyria.
Erythropoietic protoporphyria (EPP) is an inherited disease caused by loss-of-function mutations of ferrochelatase, an enzyme in the heme biosynt
Erythropoietic protoporphyria (EPP) is an inherited disease caused by loss-of-function mutations of ferrochelatase, an enzyme in the heme biosynt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec45b35c7dbec3de37a0d0107050c19
https://doi.org/10.1126/sciadv.aaw6127
https://doi.org/10.1126/sciadv.aaw6127
Autor:
Amina I. Shehu, Frank J. Gonzalez, Da Yang, Junjie Zhu, Deborah McMahon, Yue Wang, Wen Xie, Pengcheng Wang, Jie Lu, Xiaochao Ma
Publikováno v:
The Journal of clinical investigation. 129(7)
Ritonavir (RTV) is on the World Health Organization's List of Essential Medicines for antiretroviral therapy, but can cause hepatotoxicity by unknown mechanisms. Multiple clinical studies found that hepatotoxicity occurred in 100% of participants who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7262a1cf9df4b88a47bb413a5639cd
https://pubmed.ncbi.nlm.nih.gov/31039134
https://pubmed.ncbi.nlm.nih.gov/31039134
Publikováno v:
Current Pharmacology Reports. 3:10-15
Although safety of drug candidates is carefully monitored in preclinical and clinical studies using a variety of approaches, drug toxicity may still occur in clinical practice. Therefore, novel approaches are needed to complement the current drug saf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b65e9c678ac05c63866d1762c81675f
https://doi.org/10.1007/s40495-016-0079-5
https://doi.org/10.1007/s40495-016-0079-5