Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Amina Abdul-Aziz"'
Autor:
Amina Abdul-Aziz, Raymond D. Devine, Justin M. Lyberger, Hsiaochi Chang, Amy Kovacs, James R. Lerma, Andrew M. Rogers, John C. Byrd, Erin Hertlein, Gregory K. Behbehani
Publikováno v:
Cells, Vol 12, Iss 16, p 2045 (2023)
Cellular senescence is a durable cell cycle arrest as a result of the finite proliferative capacity of cells. Senescence responds to both intrinsic and extrinsic cellular stresses, such as aging, mitochondrial dysfunction, irradiation, and chemothera
Externí odkaz:
https://doaj.org/article/b530e1da01114230a49bbea1cab88c7f
Autor:
Rachel E. Piddock, Christopher R. Marlein, Amina Abdul-Aziz, Manar S. Shafat, Martin J. Auger, Kristian M. Bowles, Stuart A. Rushworth
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-4 (2018)
Abstract Multiple myeloma (MM) remains an incurable malignancy despite the recent advancements in its treatment. The protective effects of the niche in which it develops has been well documented; however, little has been done to investigate the MM ce
Externí odkaz:
https://doaj.org/article/7670a5f821bd49098c6841e166e2f8f6
Autor:
Sujay Chandran, Johnathan Watkins, Amina Abdul‐Aziz, Manar Shafat, Patrick A. Calvert, Kristian M. Bowles, Marcus D. Flather, Stuart A. Rushworth, Alisdair D. Ryding
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundPlaque erosion causes 30% of ST‐segment elevation myocardial infarctions, but the underlying cause is unknown. Inflammatory infiltrates are less abundant in erosion compared with rupture in autopsy studies. We hypothesized that erosion an
Externí odkaz:
https://doaj.org/article/e97e82911e704c39b49de12d5bfe7273
Autor:
Amina Abdul-Aziz, Kristian M. Bowles, Anna Haestier, Manar S. Shafat, Federica Di Palma, Eoghan Forde, Rachel E. Piddock, Christopher Ingham, Jayna J Mistry, Stuart A. Rushworth, Tarang K. Mehta, Iain C. Macaulay, Judith Campisi, Charlotte Hellmich, Adam Morfakis, Yu Sun, Angela Collins, Christopher R. Marlein
Publikováno v:
Blood. 133:446-456
Acute myeloid leukemia (AML) is an age-related disease that is highly dependent on the bone marrow (BM) microenvironment. With increasing age, tissues accumulate senescent cells, characterized by an irreversible arrest of cell proliferation and the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3626e520699d974d43d839ba123e22a0
https://doi.org/10.1182/blood-2018-04-845420
https://doi.org/10.1182/blood-2018-04-845420
Publikováno v:
Advances in Science, Technology and Engineering Systems Journal. 4:193-206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d4fdcdeb2679bb48f0b57743a0fb62c
https://doi.org/10.25046/aj040525
https://doi.org/10.25046/aj040525
Autor:
Sydney Fobare, Ola A. Elgamal, Emily H. Stahl, Abeera Mehmood, Jean Truxall, Mariah L. Johnson, Amina Abdul-Aziz, John C. Byrd, Erin Hertlein
Publikováno v:
Cancer Research. 82:1824-1824
Enhancer of zeste homolog 2 (EZH2) is a part of the polycomb repressive complex and catalyzes the trimethylation of lysine 27 on histone H3 (H3K27me3). EZH2 inhibition has a complex role in the pathogenesis of acute myeloid leukemia (AML), in that it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbe9b5472517b058b0265c4e2590ae7f
https://doi.org/10.1158/1538-7445.am2022-1824
https://doi.org/10.1158/1538-7445.am2022-1824
Autor:
Christopher R. Marlein, Kristian M. Bowles, Stuart A. Rushworth, Manar S. Shafat, Amina Abdul-Aziz, Martin J. Auger, Rachel E. Piddock
Publikováno v:
Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-4 (2018)
Journal of Hematology & Oncology
Journal of Hematology & Oncology
Multiple myeloma (MM) remains an incurable malignancy despite the recent advancements in its treatment. The protective effects of the niche in which it develops has been well documented; however, little has been done to investigate the MM cell’s ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf79327ee6ed92d613457b3e92b3cf8
http://link.springer.com/article/10.1186/s13045-018-0614-4
http://link.springer.com/article/10.1186/s13045-018-0614-4
Autor:
Amina Abdul-Aziz, Matthew J Lawes, Niamh V. Loughran, Manar S. Shafat, Kristian M. Bowles, Genevra Pillinger, Lyubov Zaitseva, Stuart A. Rushworth, Rachel E. Piddock
Publikováno v:
Oncotarget
Phosphoinositide-3-kinase (PI3K) is an enzyme group, known to regulate key survival pathways in acute myeloid leukaemia (AML). It generates phosphatidylinositol-3,4,5-triphosphate, which provides a membrane docking site for protein kinaseB activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16092abaffc9b4501aba8cedabe6e614
http://europepmc.org/articles/PMC5129970
http://europepmc.org/articles/PMC5129970
Publikováno v:
2018 4th International Conference on Frontiers of Signal Processing (ICFSP).
Modernization and commercialization of life lead to an unhealthy Lifestyle that results in increasing non-communicable diseases such as heart diseases and diabetes. Non-communicable diseases have direct impact on inaction, inactivity, and idleness of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71539a1da31788f5930a892dccabbce7
https://doi.org/10.1109/icfsp.2018.8552051
https://doi.org/10.1109/icfsp.2018.8552051
Autor:
Amina Abdul-Aziz, Zhigang Zhou, Angela Collins, Stephen D. Robinson, Yu Sun, Stuart A. Rushworth, Kristian M. Bowles, Dylan R. Edwards, Rachel E. Piddock, Christopher R. Marlein, Manar S. Shafat
Approximately 80% of patients diagnosed with acute myeloid leukemia (AML) die as a consequence of failure to eradicate the tumor from the bone marrow microenvironment. We have recently shown that stroma-derived interleukin-8 (IL-8) promotes AML growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d825c71575c9225ab1a6144f58f11bdb
https://ueaeprints.uea.ac.uk/id/eprint/66534/
https://ueaeprints.uea.ac.uk/id/eprint/66534/
