Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amina, Mulani"'
Autor:
W. Cameron Black, Michael Zinda, Jordan T.F. Young, Zuomei Li, Yael Mamane, Rino Stocco, Martine Hamel, Artur Veloso, Victoria Rimkunas, Amina Mulani, Kathryn Skorey, Sabrina Vignini-Hammond, Chloe Fugère-Desjardins, William Yang, Hunain Alam, Amandine Chefson, Shou Yun Yin, Marie-Eve Leclaire, Li Li, Sara Fournier, Lee D. Fader, Stéphane Dorich, Valerie Dumais, Émilie Dumas-Bérube, Charles Pellerin, Alexander Skeldon, Robert Papp, Michal Zimmermann, Anne Roulston
Supplementary Methods, Tables, Figures and References
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062cfaf9177f49a3206feb599326f494
https://doi.org/10.1158/1535-7163.22896018
https://doi.org/10.1158/1535-7163.22896018
Autor:
W. Cameron Black, Michael Zinda, Jordan T.F. Young, Zuomei Li, Yael Mamane, Rino Stocco, Martine Hamel, Artur Veloso, Victoria Rimkunas, Amina Mulani, Kathryn Skorey, Sabrina Vignini-Hammond, Chloe Fugère-Desjardins, William Yang, Hunain Alam, Amandine Chefson, Shou Yun Yin, Marie-Eve Leclaire, Li Li, Sara Fournier, Lee D. Fader, Stéphane Dorich, Valerie Dumais, Émilie Dumas-Bérube, Charles Pellerin, Alexander Skeldon, Robert Papp, Michal Zimmermann, Anne Roulston
Ataxia telangiectasia and Rad3-related (ATR) kinase protects genome integrity during DNA replication. RP-3500 is a novel, orally bioavailable clinical-stage ATR kinase inhibitor (NCT04497116). RP-3500 is highly potent with IC50 values of 1.0 and 0.33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a51beae2425d617ba7d0ef61e96c7e6
https://doi.org/10.1158/1535-7163.c.6651330.v1
https://doi.org/10.1158/1535-7163.c.6651330.v1
Autor:
Anne Roulston, Michal Zimmermann, Robert Papp, Alexander Skeldon, Charles Pellerin, Émilie Dumas-Bérube, Valerie Dumais, Stéphane Dorich, Lee D. Fader, Sara Fournier, Li Li, Marie-Eve Leclaire, Shou Yun Yin, Amandine Chefson, Hunain Alam, William Yang, Chloe Fugère-Desjardins, Sabrina Vignini-Hammond, Kathryn Skorey, Amina Mulani, Victoria Rimkunas, Artur Veloso, Martine Hamel, Rino Stocco, Yael Mamane, Zuomei Li, Jordan T.F. Young, Michael Zinda, W. Cameron Black
Publikováno v:
Molecular Cancer Therapeutics. 21:245-256
Ataxia telangiectasia and Rad3-related (ATR) kinase protects genome integrity during DNA replication. RP-3500 is a novel, orally bioavailable clinical-stage ATR kinase inhibitor (NCT04497116). RP-3500 is highly potent with IC50 values of 1.0 and 0.33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c5c2c693c809fd51b04d00ce59692a4
https://doi.org/10.1158/1535-7163.mct-21-0615
https://doi.org/10.1158/1535-7163.mct-21-0615
Autor:
Anne Roulston, Michal Zimmerman, Robert Papp, Alex Skeldon, Charles Pellerin, Émilie Dumas-Bérube, Valerie Dumais, Stephane Dorich, Sara Fournier, Li Li, Marie-Ève Leclaire, Shou Yun Yin, Amandine Chefson, Hunain Alam, William Yang, Chloe Fugère-Desjardins, Sabrina Hammond, Kathryn Skorey, Amina Mulani, Victoria Rimkunas, Artur Veloso, Martine Hamel, Rino Stocco, Yael Mamane, Zuomei Li, Jordan Young, Mike Zinda, Cameron Black
Publikováno v:
Molecular Cancer Therapeutics. 20:P054-P054
Background: Ataxia telangiectasia and Rad3-related (ATR) protein kinase is a key mediator of cellular DNA damage repair (DDR) and is activated in response to DNA replication stress. ATR is attractive as a drug target in tumors with loss-of-function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64546a898e05e3470c5622263c464f40
https://doi.org/10.1158/1535-7163.targ-21-p054
https://doi.org/10.1158/1535-7163.targ-21-p054
Autor:
Hadil F Al-Jallad, Vamsee D Myneni, Sarah A Piercy-Kotb, Nicolas Chabot, Amina Mulani, Jeffrey W Keillor, Mari T Kaartinen
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15893 (2011)
Transglutaminase activity, arising potentially from transglutaminase 2 (TG2) and Factor XIIIA (FXIIIA), has been linked to osteoblast differentiation where it is required for type I collagen and fibronectin matrix deposition. In this study we have us
Externí odkaz:
https://doaj.org/article/391e9309bc0b4d7599052a630beb9019
Autor:
Amina Mulani, Kim Y.P. Apperley, Jeffrey W. Keillor, Christopher M. Clouthier, Abdullah Akbar
Publikováno v:
Bioorganic Chemistry. 57:186-197
Tissue transglutaminase (TG2) is a calcium-dependent enzyme that catalyses several acyl transfer reactions. The most biologically relevant of these involve protein-bound Gln residues as an acyl-donor substrate, and either water or a primary amine as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c838de73f2a48b98baca3772031ab9b
https://doi.org/10.1016/j.bioorg.2014.06.003
https://doi.org/10.1016/j.bioorg.2014.06.003
Publikováno v:
Chemistry & Biology. 17(10):1143-1150
SummaryTissue transglutaminase (TG2) catalyzes the crosslinking of proteins. TG2 has been implicated in fibrosis and vascular calcification, both of which lead to a common feature of aging known as arterial stiffness. In order to probe the role of TG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92b770b13373d5da308719331b59ef3
Autor:
Jeffrey W, Keillor, Nicolas, Chabot, Isabelle, Roy, Amina, Mulani, Olivier, Leogane, Christophe, Pardin
Publikováno v:
Advances in enzymology and related areas of molecular biology. 78
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ada217671fd211617e4889b8ba1ca27
https://pubmed.ncbi.nlm.nih.gov/22220480
https://pubmed.ncbi.nlm.nih.gov/22220480
Autor:
Amina Mulani, Isabelle Roy, Christophe Pardin, Nicolas Chabot, Jeffrey W. Keillor, Olivier Leogane
Publikováno v:
Advances in Enzymology: And Related Areas of Molecular Biology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b853f985400f4ee421ed881830d8f93d
https://doi.org/10.1002/9781118105771.ch10
https://doi.org/10.1002/9781118105771.ch10
Autor:
Sarah A. Piercy-Kotb, Amina Mulani, Mari T. Kaartinen, Vamsee D. Myneni, Jeffrey W. Keillor, Hadil Al-Jallad, Nicolas Chabot
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15893 (2011)
PLoS ONE
PLoS ONE
Transglutaminase activity, arising potentially from transglutaminase 2 (TG2) and Factor XIIIA (FXIIIA), has been linked to osteoblast differentiation where it is required for type I collagen and fibronectin matrix deposition. In this study we have us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fed8ca01bf53d1f3f291d33e534699
http://europepmc.org/articles/PMC3024320?pdf=render
http://europepmc.org/articles/PMC3024320?pdf=render