Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Amin Famili"'
Autor:
Yvonne Chen, Maciej Paluch, Julie A. Zorn, Sharmila Rajan, Brandon Leonard, Alberto Estevez, John Brady, Henry Chiu, Wilson Phung, Amin Famili, Minhong Yan, Claudio Ciferri, Marissa L. Matsumoto, Greg A. Lazar, Susan Crowell, Phil Hass, Nicholas J. Agard
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Treatment of ocular disease is hindered by the presence of the blood-retinal barrier, which restricts access of systemic drugs to the eye. Intravitreal injections bypass this barrier, delivering high concentrations of drug to the targeted tissue. How
Externí odkaz:
https://doaj.org/article/28ad3cfcdaf4459abab263005b66f32a
Autor:
Mohammad Al-Sayah, Dennis Leung, Purnendu K. Nayak, Amin Famili, Debby P. Chang, Meenakshi Goel
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 165:185-192
Poly (lactic-co-glycolic acid) (PLGA), a biocompatible and biodegradable polymer, is one of the most commonly used vehicles for controlled-release (CR) implantable dosage forms. Drug molecules formulated in such CR vehicles are released slowly over a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68524ed470988c3fd80ba14f23107f97
https://doi.org/10.1016/j.ejpb.2021.05.008
https://doi.org/10.1016/j.ejpb.2021.05.008
Autor:
Danielle Mandikian, David Cain, Kelly M. Loyet, Laetitia Comps-Agrar, Joyce Chan, Amrita V. Kamath, Karthikan Rajagopal, Susan Crowell, Amin Famili, C. Andrew Boswell
Publikováno v:
Bioconjugate Chemistry. 30:2782-2789
Treatment of ocular diseases associated with neovascularization currently requires frequent intravitreal injections of antivascular endothelial growth factor (anti-VEGF) therapies. Reducing the required frequency of anti-VEGF injections and associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d0785bd06c82e90ce73131f084d962
https://doi.org/10.1021/acs.bioconjchem.9b00475
https://doi.org/10.1021/acs.bioconjchem.9b00475
Autor:
Chun-Wan Yen, Lu Dai, Steven Chin, Brian Roper, Elizabeth S. Hecht, Chloe Hu, Cadapakam Venkatramani, Nisana Andersen, Robert Kuhn, Dennis Leung, Fiona Lin, Jason Gruenhagen, Christopher M. Crittenden, Alberto Estevez, Mohammad Al-Sayah, Amin Famili, Lance Cadang, Tao Chen, Shijia Tang, Cinzia Stella, Karthik Nagapudi, Peter Yehl, Richard Vandlen, Peter Liu, Alexis Rohou, Debby P. Chang, Rami N. Hannoush
Publikováno v:
Journal of Pharmaceutical Sciences.
Constrained peptides (CPs) have emerged as attractive candidates for drug discovery and development. To fully unlock the therapeutic potential of CPs, it is crucial to understand their physical stability and minimize the formation of aggregates that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e078389a18d4495af32516044ad50a61
https://doi.org/10.1016/j.xphs.2020.12.041
https://doi.org/10.1016/j.xphs.2020.12.041
Autor:
Alberto Estevez, Sharmila Rajan, John Ridgway Brady, Henry Chiu, Phil Hass, Claudio Ciferri, Greg A. Lazar, Amin Famili, Brandon Leonard, Nicholas J. Agard, Julie A. Zorn, Susan Crowell, Yvonne Chen, Marissa L. Matsumoto, Maciej Paluch, Wilson Phung, Minhong Yan
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Treatment of ocular disease is hindered by the presence of the blood-retinal barrier, which restricts access of systemic drugs to the eye. Intravitreal injections bypass this barrier, delivering high concentrations of drug to the targeted tissue. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2972d610295bf6786c86ef9329b3c291
https://doi.org/10.1080/19420862.2020.1818436
https://doi.org/10.1080/19420862.2020.1818436
Autor:
Amin Famili, Karthikan Rajagopal
Publikováno v:
Molecular Pharmaceutics. 14:1961-1968
Chemically cross-linked hydrogels are promising systems for protein delivery applications, but their utility may be limited due to the possibility of protein reaction with hydrogel precursors. Herein, a catalyst-free inverse-demand Diels-Alder reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad29e332551538c7c454bdf0d4851a1
https://doi.org/10.1021/acs.molpharmaceut.7b00067
https://doi.org/10.1021/acs.molpharmaceut.7b00067
Publikováno v:
Pharmaceutics
Micro- and nano-carrier formulations have been developed as drug delivery systems for active pharmaceutical ingredients (APIs) that suffer from poor physico-chemical, pharmacokinetic, and pharmacodynamic properties. Encapsulating the APIs in such sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cd7e89002ba64de2ae5d32457edcc9
https://pubmed.ncbi.nlm.nih.gov/31775292
https://pubmed.ncbi.nlm.nih.gov/31775292
Publikováno v:
Drug discovery today. 24(8)
Hydrogels are water-laden polymer networks that have been used for myriad biological applications. By controlling the chemistry through which a hydrogel is constructed, a wide range of chemical and physical properties can be accessed, making them an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6656e03c14569ea1c903b094a60cddb2
https://pubmed.ncbi.nlm.nih.gov/31202673
https://pubmed.ncbi.nlm.nih.gov/31202673
Publikováno v:
Macromolecular Bioscience. 14:1719-1729
We have developed an in situ-gelling polymer system comprised of drug-loaded micelles encapsulated within a reverse thermal gel (RTG) as an injectable ocular drug delivery system. The RTG chemistry employs a novel poly(N-isopropylacrylamide) (PNIPAAm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b16ac0978073c32c121d6ccdbddcce2f
https://doi.org/10.1002/mabi.201400250
https://doi.org/10.1002/mabi.201400250