Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Amin Dilip"'
Autor:
Lipworth, Brian J., Kaliner, Michael A., LaForce, Craig F., Baker, James W., Kaiser, Harold B., Amin, Dilip, Kundu, Sudeep, Williams, James E., Engelstaetter, Renate, Banerji, Donald D.
Publikováno v:
In Annals of Allergy, Asthma & Immunology 2005 94(4):465-472
Autor:
Robert J. Leadley, Charles Kasiewski, Tara Wentz, Glenda E. Bilder, Jeffery Bostwick, Mark H. Perrone, Saul J. Needle, Betsey O’Conner, Christopher T. Dunwiddie, Lisa Byan, Kenneth Page, Helen Galczenski, Linda Merkel, Persons Paul E, Myers Michael R, Alfred P. Spada, Amin Dilip, Cuong Ly
Publikováno v:
Circulation. 99:3292-3299
Background —Platelet-derived growth factor (PDGF), a purported mediator of arterial response to injury, stimulates proliferation, chemotaxis, and matrix production by activation of its membrane receptor tyrosine kinase. Because these activities und
Autor:
Doan Kim-Anh Thi, Michael Jaye, Daniel J. Rader, Kevin J. Lynch, Dawn Marchadier, Mark H. Perrone, Amin Dilip, Cyrille Maugeais, Krawiec John A, South Victoria J
Publikováno v:
Nature Genetics. 21:424-428
High-density lipoprotein (HDL) cholesterol levels are inversely associated with risk of atherosclerotic cardiovascular disease. At least 50% of the variation in HDL cholesterol levels is genetically determined, but the genes responsible for variation
Autor:
Saul J. Needle, Amin Dilip, Sheng Yuh Tang, Glenda E. Bilder, Helen Galczenski, Linda Merkel, Donald Lewis, Camilo J. Rojas, Mark H. Perrone, Marie M. Gleason
Publikováno v:
Steroids. 60:475-483
Two separate enzymatic assays were developed in order to test the selectivity of inhibitors in cholesterol biosynthesis. One assay detects inhibition of delta 5.7-sterol delta 7-reductase, the enzyme involved in the conversion of 7-dehydrocholesterol
Autor:
Mark H. Perrone, Susan A. Cornell, Glenda E. Bilder, John W. Ullrich, Susan Gustafson, Saul J. Needle, Amin Dilip
Publikováno v:
Journal of Lipid Research, Vol 33, Iss 11, Pp 1657-1663 (1992)
Some bisphosphonates used for the treatment of bone disorders are also potent inhibitors of squalene synthase, a critical enzyme for sterol biosynthesis. Among seven drugs tested, YM 175 (cycloheptylaminomethylene-1,1-bisphosphonic acid) was the most
Publikováno v:
European Journal of Medicinal Chemistry. 27:735-742
We report on a series of potent inhibitors of HMG-CoA reductase (HMGR) that were designed to examine the biological consequences that result from molecular changes in RG 12561. The introduction of functional groups on the cyclohexene nucleus of RG 12
Autor:
Matthew J. McVey, Lisa A. Morgan, Wei He, Glenda Bilder, Spada Alfred P, Chandra Natajaran, Mark H. Perrone, Yongyi Luo, Saul Needle, Amin Dilip, Myers Michael R, Robert J. Leadley, Helen Galczenski
Publikováno v:
Journal of cardiovascular pharmacology. 41(6)
Activities of vascular smooth muscle cells (SMCs) such as proliferation, migration, and matrix production contribute to restenosis following clinical interventions of angioplasty and stent placement. Because activation of platelet-derived growth fact
Autor:
Glenda E. Bilder, D.J. Hele, Amin Dilip, R.C. Bush, Ruth Z. Rutledge, Kent Neuenswander, Saul J. Needle, Mark H. Perrone
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 353
RPR 101821 (trans-2-[4-(benzoxazol-2-yl)-phenylmethoxy] amino cyclohexane hydrochloride) is a potent cholesterol-lowering agent in rodents and marmoset. The compound inhibited rat liver microsomal squalene synthase (IC50 = 1 nM) and 7-dehydrocholeste
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Autor:
Myers, Michael R., He, Wei, Hanney, Barbara, Setzer, Natalie, Maguire, Martin P., Zulli, Allison, Bilder, Glenda, Galzcinski, Helen, Amin, Dilip, Needle, Saul, Spada, Alfred P.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 2003 13(18):3091-3095