Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Amila K. Nanayakkara"'
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Akademický článek
Prolonged inhibition of P-glycoprotein after exposure to chemotherapeutics increases cell mortality in multidrug resistant cultured cancer cells.
Autor: Amila K Nanayakkara, Pia D Vogel, John G Wise
Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0217940 (2019)
One common reason for cancer chemotherapy failure is increased drug efflux catalyzed by membrane transporters with broad pump substrate specificities, which leads to resistances to a wide range of chemically unrelated drugs. This multidrug resistance
Externí odkaz: https://doaj.org/article/85d7256a0d574f3583a1a41897f6c7fd
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2
Antibiotic resistance in the patient with cancer: Escalating challenges and paths forward
Autor: David E. Greenberg, Amanda Jezek, Kevin Outterson, Amila K. Nanayakkara, Vance G. Fowler, Helen W. Boucher
Publikováno v: CA: A Cancer Journal for Clinicians. 71:488-504
Infection is the second leading cause of death in patients with cancer. Loss of efficacy in antibiotics due to antibiotic resistance in bacteria is an urgent threat against the continuing success of cancer therapy. In this review, the authors focus o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e059fc2bb4b77ed1535c24a542910847
https://doi.org/10.3322/caac.21697
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3
Optimizing Targeted Inhibitors of P-Glycoprotein Using Computational and Structure-Guided Approaches
Autor: Maha Aljowni, Pia D. Vogel, Gang Chen, John G. Wise, Amila K. Nanayakkara, Maisa C. Oliveira, Ketetha Olengue, Alexander R. Lippert, Lauren Ammerman
Publikováno v: J Med Chem
Overexpression of ABC transporters like P-glycoprotein (P-gp) has been correlated with resistances in cancer chemotherapy. Intensive efforts to identify P-gp inhibitors for use in combination therapy have not led to clinically approved inhibitors to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df215630ba7076fcf2fba75f58deef2
https://doi.org/10.1021/acs.jmedchem.9b00966
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9
Targeted inhibitors of P-glycoprotein increase chemotherapeutic-induced mortality of multidrug resistant tumor cells
Autor: Courtney A. Follit, John G. Wise, Gang Chen, Pia D. Vogel, Amila K. Nanayakkara, Noelle S. Williams
Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-18 (2018)
Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one of the best studied drug transporters associated with MDR. There are currently no approved
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bda29d9586f3aab8f79ab5d6b16958
https://doi.org/10.1038/s41598-018-19325-x
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