Pain Therapy Guided by Purpose and Perspective in Light of the Opioid Epidemic

Autor: Amie L. Severino, Arash Shadfar, Joshua K. Hakimian, Oliver Crane, Ganeev Singh, Keith Heinzerling, Wendy M. Walwyn

Publikováno v: Frontiers in Psychiatry, Vol 9 (2018)

Prescription opioid misuse is an ongoing and escalating epidemic. Although these pharmacological agents are highly effective analgesics prescribed for different types of pain, opioids also induce euphoria, leading to increasing diversion and misuse.

Externí odkaz: https://doaj.org/article/ff8bc8d155ee4ae8af3010f5960c863a

μ-Opioid Receptors on Distinct Neuronal Populations Mediate Different Aspects of Opioid Reward-Related Behaviors

Autor: Suchi Tiwari, Ralph Albert, Anna M.W. Taylor, Ani Minasyan, Joshua K. Hakimian, Nicole Romaneschi, Catherine M. Cahill, Wendy Walwyn, Nitish Mittal, Alex Lee, Camille Johnston, Amie L. Severino, Christopher J. Evans, Carlos Torres, Brigitte L. Kieffer, Nathanial Velarde, Claire Gaveriaux-Ruff

Publikováno v: eNeuro
eNeuro, 2020, 7 (5), pp.0146-20. ⟨10.1523/ENEURO.0146-20.2020⟩
eNeuro, vol 7, iss 5

μ-Opioid receptors (MORs) are densely expressed in different brain regions known to mediate reward. One such region is the striatum where MORs are densely expressed, yet the role of these MOR populations in modulating reward is relatively unknown. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4499cdae59ee8841a7bb87ed6ca90f13
https://hal.science/hal-03669760/file/islandora_151108.pdf

Coordination of escape and spatial navigation circuits orchestrates versatile flight from threats

Autor: Mimi Q La-Vu, Amie L. Severino, Miguel Antonio Xavier de Lima, Weisheng Wang, Lilly Lin, Fernando M. C. V. Reis, Baljit S. Khakh, Saskia J. Leonard, Jonathan C. Kao, Sandra Maesta-Pereira, Peter J Schuette, Meghmik Chakerian, Catherine M. Cahill, Avishek Adhikari, Jun Nagai, Shiyu Ji, Brooke C Tobias, Newton S. Canteras

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neuron
Neuron, vol 109, iss 11

Naturalistic escape requires versatile context-specific flight with rapid evaluation of local geometry to identify and use efficient escape routes. It is unknown how spatial navigation and escape circuits are recruited to produce context-specific fli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05680596b9034bcb9d763ee63dec762b
https://doi.org/10.1016/j.neuron.2021.03.033

Digging through the roots of addiction: Understanding the causes that underlie the insidious problem of substance use disorders (SUDs)

Autor: Amie L. Severino, Christopher J. Evans

Publikováno v: Neurosci Biobehav Rev

This issue features a selection of articles that explore mechanisms of processes that contribute to behaviors that are associated with addiction. We have identified selected articles which focus on the mechanisms underlying maladaptive consumption an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5455352fe28b2bbaab6586a8776e9995
https://pubmed.ncbi.nlm.nih.gov/31561848

Plasticity and Function of Spinal Oxytocin and Vasopressin Signaling during Recovery from Surgery with Nerve Injury

Autor: Haiguo Sun, Bethany Pan, Silvia Gutierrez, Amie L. Severino, Christopher M. Peters, Rong Chen, James C. Eisenach, Ken-ichiro Hayashida, Carol A. Aschenbrenner

Publikováno v: Anesthesiology. 129(3)

What We Already Know about This Topic What This Article Tells Us That Is New Background Recovery from pain after surgery is faster after cesarean delivery than after other abdominal procedures. The authors hypothesized that recovery in rats after sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45a461f75c51f768a68b15dfaf353a5
https://pubmed.ncbi.nlm.nih.gov/29912007