Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Amie L Phinney"'
Autor:
Erwan Paitel, Toshitaka Kawarai, Katsunori Iwasaki, Atsushi Sasaki, Koji Abe, Jing Yang, Mikio Shoji, Patrick Horne, Yasuo Harigaya, George A. Carlson, Peter St George-Hyslop, Christopher Janus, Mitsuo Takahashi, Nobuaki Egashira, M. Azhar Chishti, Takeshi Kawarabayashi, David Westaway, Amanda Hanna, Amie L. Phinney, Koichi Ishiguro, Etsuro Matsubara, Kenichi Mishima, Masaki Ikeda, Tetsuro Murakami, Michihiro Fujiwara, Catherine Bergeron
Publikováno v:
The American Journal of Pathology. 169:1365-1375
Recapitulation of tau pathologies in an animal model has been a long-standing goal in neurodegenerative disease research. We generated transgenic (TgTau P301L ) mice expressing a frontotemporal dementia with parkinsonism linked to chromosome 17 (FTPD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69b91fdaded1f1a0c73f1f7b02bf504c
https://doi.org/10.2353/ajpath.2006.051250
https://doi.org/10.2353/ajpath.2006.051250
Publikováno v:
European Journal of Neuroscience. 19:1731-1740
Denervation of the dentate gyrus by entorhinal cortex lesion has been widely used to study the reorganization of neuronal circuits following central nervous system lesion. Expansion of the non-denervated inner molecular layer (commissural/association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bb686b9fdbdb5b81a620c893b521fd7
https://doi.org/10.1111/j.1460-9568.2004.03280.x
https://doi.org/10.1111/j.1460-9568.2004.03280.x
Publikováno v:
Neurological Research. 25:590-600
Alzheimer's disease (AD) is characterized by memory impairment leading to dementia, deposition of amyloid plaques and neurofibrillary tangles (NFTs), and neuronal loss. The major component of plaques is the amyloid beta peptide, A beta, whereas NFTs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f30a70739a34671d237811f12fc976
https://doi.org/10.1179/016164103101202020
https://doi.org/10.1179/016164103101202020
Autor:
Thomas Deller, Carl Gebhardt, Domenico Del Turco, Michael Frotscher, Mathias Jucker, Amie L. Phinney, Alisa G. Woods
Publikováno v:
Hippocampus. 13:685-699
Reactive axonal sprouting occurs in the fascia dentata after entorhinal cortex lesion. This sprouting process has been described extensively in the rat, and plasticity-associated molecules have been identified that might be involved in its regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb43d34cae3481d8680592f5958de82
https://doi.org/10.1002/hipo.10118
https://doi.org/10.1002/hipo.10118
Autor:
Michael Przybylski, David Westaway, Christopher Janus, Paul E. Fraser, Janet French, Amie L. Phinney, Mark H. L. Lambermon, Xiaodan Tian, Patrick Horne, Roxana Cecal, Audrey A. Darabie, Michael Brown, Marilena Manea, Meredith E. Kierstead, P. St. George-Hyslop, Howard T.J. Mount, M A Chishti, JoAnne McLaurin
Publikováno v:
Nature Medicine. 8:1263-1269
Immunization of transgenic mouse models of Alzheimer disease using amyloid-beta peptide (Abeta) reduces both the Alzheimer disease-like neuropathology and the spatial memory impairments of these mice. However, a therapeutic trial of immunization with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd97e74f50eecb658239ebbe3d567db6
https://doi.org/10.1038/nm790
https://doi.org/10.1038/nm790
Autor:
Luca Bondolfi, Michelle Pfeifer, Peter H. Kelly, Martina Stalder, Sonia Boncristiano, Mathias Jucker, Michael E. Calhoun, Matthias Staufenbiel, Amie L. Phinney, Bernd Sommer, Dorothee Abramowski, Albert Enz, Christine Sturchler-Pierrat
Publikováno v:
The Journal of Neuroscience. 22:3234-3243
Alzheimer's Disease (AD) is a neurodegenerative disorder that is characterized by extracellular deposits of amyloid-beta peptide (Abeta) and a severe depletion of the cholinergic system, although the relationship between these two events is poorly un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a69a891d213f9023d905fa6fab2083
https://doi.org/10.1523/jneurosci.22-08-03234.2002
https://doi.org/10.1523/jneurosci.22-08-03234.2002
Publikováno v:
Current Neurology and Neuroscience Reports. 1:451-457
Alzheimer's disease (AD) is characterized by deterioration in mental function leading to dementia, deposition of amyloid plaques and neurofibrillary tangles (NFTs), and neuronal loss. The major component of plaques is the amyloid-beta peptide (A beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c79415a925a498cd9730753015dba5
https://doi.org/10.1007/s11910-001-0105-8
https://doi.org/10.1007/s11910-001-0105-8
Autor:
Mathias Jucker, Hans-Peter Lipp, Michael E. Calhoun, H. Zheng, David P. Wolfer, Amie L. Phinney
Publikováno v:
Neuroscience. 90:1207-1216
Aged beta-amyloid precursor protein-null mice were used to investigate the relationship between beta-amyloid precursor protein, hippocampal neuron and synaptic bouton number, and cognitive function. Learning and memory performance of aged beta-amyloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e674b37932eb0a17fd328cecd75235
https://doi.org/10.1016/s0306-4522(98)00645-9
https://doi.org/10.1016/s0306-4522(98)00645-9
Autor:
Matthias Staufenbiel, Bernd Sommer, Amie L. Phinney, Martina Stalder, Alphonse Probst, Mathias Jucker
Publikováno v:
The American Journal of Pathology. 154:1673-1684
Microglia are a key component of the inflammatory response in the brain and are associated with senile plaques in Alzheimer's disease (AD). Although there is evidence that microglial activation is important for the pathogenesis of AD, the role of mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c186231dee0c732032f226ac8845af70
https://doi.org/10.1016/s0002-9440(10)65423-5
https://doi.org/10.1016/s0002-9440(10)65423-5
Autor:
Amie L Phinney, Vliet Bernard J Van, Olli Gröhn, Taina-Kaisa Stenius, Juha Yrjänheikki, Taneli Heikkinen, Tinka Tuinstra, Antti Nurmi, Riikka Immonen, Leena Tähtivaara, Jukka Puoliväli
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 30(7)
In the traumatic brain injury (TBI) the initial impact causes both primary injury, and launches secondary injury cascades. One consequence, and a factor that may contribute to these secondary changes and functional outcome, is altered hemodynamics. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225f74852b85b0e21c0ae6743628df84
https://pubmed.ncbi.nlm.nih.gov/20145657
https://pubmed.ncbi.nlm.nih.gov/20145657