Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amie Jobe"'
Autor:
Amie Jobe, Ranjit Vijayan
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
G protein-coupled receptors (GPCRs) make up the largest receptor superfamily, accounting for 4% of protein-coding genes. Despite the prevalence of such transmembrane receptors, a significant number remain orphans, lacking identified endogenous ligand
Externí odkaz:
https://doaj.org/article/5e0f40e4e0b84c3c94eb1f966f3ff330
Autor:
Shamsa Husain Ahmed Alhammadi, Bincy Baby, Priya Antony, Amie Jobe, Raghad Salman Mohammed Humaid, Fatema Jumaa Ahmed Alhammadi, Ranjit Vijayan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 12, p 6529 (2024)
Mcl-1 (myeloid cell leukemia 1), a member of the Bcl-2 family, is upregulated in various types of cancer. Peptides representing the BH3 (Bcl-2 homology 3) region of pro-apoptotic proteins have been demonstrated to bind the hydrophobic groove of anti-
Externí odkaz:
https://doaj.org/article/87de8818e71b4420b6d53230f711ec12
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Hemorphins, short bioactive peptides produced by enzymatic cleavage of β-hemoglobin, exhibit antihypertensive properties by inhibiting angiotensin-1 converting enzyme (ACE1). ACE1 is a key player in the renin–angiotensin system (RAS) and
Externí odkaz:
https://doaj.org/article/3dcf70ae5cb34bcf81bd9f33863e446c
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 3059 (2024)
Type 2 diabetes is a chronic metabolic disorder characterized by high blood glucose levels due to either insufficient insulin production or ineffective utilization of insulin by the body. The enzyme dipeptidyl peptidase IV (DPP IV) plays a crucial ro
Externí odkaz:
https://doaj.org/article/56d229249f6643168902de8b7feb9d96
Publikováno v:
PeerJ, Vol 10, p e13680 (2022)
Background The COVID-19 pandemic is still a global public health issue. Omicron, a SARS-CoV-2 B.1.1.529 variant, has raised concerns about transmission and vaccine effectiveness. Omicron currently has the greatest number of variantions. Methods To ga
Externí odkaz:
https://doaj.org/article/70e5ac7d26e848c8a65c1080bf1b19f4
Autor:
Amie Jobe, Ranjit Vijayan
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 1889-1895 (2021)
Viral internalization is aided by host cell surface receptors. In the case of SARS-CoV-2 and SARS-CoV, the primary host receptor is the angiotensin-converting enzyme 2 (ACE2). Considering the disparities in the transmission rate and viral tropism of
Externí odkaz:
https://doaj.org/article/53b2b2b624f04dbaa878e1a0996af3fe
Autor:
Feyisola Fisayo Ajayi, Priti Mudgil, Amie Jobe, Priya Antony, Ranjit Vijayan, Chee-Yuen Gan, Sajid Maqsood
Publikováno v:
Foods, Vol 12, Iss 6, p 1327 (2023)
Hypercholesterolemia remains a serious global public health concern. Previously, synthetic anti-hypercholesterolemic drugs were used for ameliorating this condition; however, long-term usage presented several side-effects. In this regard, natural pro
Externí odkaz:
https://doaj.org/article/9292b020f7e24c6fb3f50bc34b5af25a
Autor:
Amie Jobe, Ranjit Vijayan
Publikováno v:
Heliyon, Vol 7, Iss 10, Pp e08251- (2021)
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern. It is now well established that the spike (S) protein of SARS-CoV-2 interacts with its p
Externí odkaz:
https://doaj.org/article/a49678aaeb664a009524ce508deb1fcd
Publikováno v:
International Journal of Computational Biology and Drug Design. 14:103
The prevalence of obesity has remarkably increased in recent decades. An important strategy to combat obesity is to reduce the imbalance between energy intake and expenditure. Pancreatic lipase (PL) and acetyl coenzyme A carboxylase 2 (ACC2) are two