Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ameya S. Kulkarni"'
Autor:
Lindsay R. Stolzenburg, Sahar Esmaeeli, Ameya S. Kulkarni, Erin Murphy, Taekyung Kwon, Christina Preiss, Lamiaa Bahnassawy, Joshua D. Stender, Justine D. Manos, Peter Reinhardt, Fedik Rahimov, Jeffrey F. Waring, Cyril Y. Ramathal
Publikováno v:
PLoS ONE, Vol 18, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/022eb49840ba4ff4bc4b38415d10380a
Autor:
Camille R. Brightwell, Ameya S. Kulkarni, William Paredes, Kehao Zhang, Jaclyn B. Perkins, Knubian J. Gatlin, Matthew Custodio, Hina Farooq, Bushra Zaidi, Rima Pai, Rupinder S. Buttar, Yan Tang, Michal L. Melamed, Thomas H. Hostetter, Jeffrey E. Pessin, Meredith Hawkins, Christopher S. Fry, Matthew K. Abramowitz
Publikováno v:
JCI Insight, Vol 6, Iss 24 (2021)
BACKGROUND Skeletal muscle maladaptation accompanies chronic kidney disease (CKD) and negatively affects physical function. Emphasis in CKD has historically been placed on muscle fiber–intrinsic deficits, such as altered protein metabolism and atro
Externí odkaz:
https://doaj.org/article/28e2b2ab95fc4aababe1574c610d359a
Autor:
Ameya S Kulkarni, Justin Ideozu, Aparna Vasanthakumar, Areej Ammar, Erin Murphy, Elizabeth Asque, Christian Plaas, Corinna Klein, Janina S Ried, Stefan Barghorn, Laura Gasparini
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a169d6cb02953240ce275e057eaa6c4
https://doi.org/10.1002/alz.060736
https://doi.org/10.1002/alz.060736
Autor:
Ameya S. Kulkarni, Sandra Aleksic, David M. Berger, Felipe Sierra, George A. Kuchel, Nir Barzilai
Publikováno v:
Aging Cell. 21
Common chronic diseases represent the greatest driver of rising healthcare costs, as well as declining function, independence, and quality of life. Geroscience-guided approaches seek to delay the onset and progression of multiple chronic conditions b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe34c2262c86d9e71a65c65ff24a8343
https://doi.org/10.1111/acel.13596
https://doi.org/10.1111/acel.13596
Publikováno v:
Cell Metab
Biological aging involves an interplay of conserved and targetable molecular mechanisms, summarized as the hallmarks of aging. Metformin- a biguanide that combats age-related disorders and improves healthspan, is the first drug to be tested for its a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3594ae1eb149919531ed125a6a7018d6
https://doi.org/10.1016/j.cmet.2020.04.001
https://doi.org/10.1016/j.cmet.2020.04.001
BackgroundSingle cell RNA sequencing (scRNA-seq) methods have been advantageous for quantifying cell-to-cell variation by profiling the transcriptomes of individual cells. For scRNA-seq data, variability in gene expression reflects the degree of vari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2070d0d21d95193157c36a63e3273df3
https://doi.org/10.1101/2022.02.13.480299
https://doi.org/10.1101/2022.02.13.480299
Autor:
Zuen Ren, Huizhi Liang, Phillip M. Galbo, Malindrie Dharmaratne, Ameya S. Kulkarni, Atefeh Taherian Fard, Marie Louise Aoun, Nuria Martinez-Lopez, Kimita Suyama, Outhiriaradjou Benard, Wei Zheng, Yang Liu, Joseph Albanese, Deyou Zheng, Jessica C. Mar, Rajat Singh, Michael B. Prystowsky, Larry Norton, Rachel B. Hazan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(8)
In search of redox mechanisms in breast cancer, we uncovered a striking role for glutathione peroxidase 2 (GPx2) in oncogenic signaling and patient survival. GPx2 loss stimulates malignant progression due to reactive oxygen species/hypoxia inducible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d3ddbdc136467198be12587b589351
https://pubmed.ncbi.nlm.nih.gov/36330399
https://pubmed.ncbi.nlm.nih.gov/36330399
Autor:
Michal L. Melamed, Knubian J Gatlin, Kehao Zhang, Rima Pai, Thomas H. Hostetter, Jeffrey E. Pessin, Camille R. Brightwell, Hina Farooq, Christopher S. Fry, Meredith Hawkins, Rupinder S. Buttar, Yan Tang, Matthew K. Abramowitz, Jaclyn B Perkins, Ameya S Kulkarni, Matthew Custodio, William Paredes, Bushra Zaidi
Publikováno v:
JCI Insight
BACKGROUND Skeletal muscle maladaptation accompanies chronic kidney disease (CKD) and negatively affects physical function. Emphasis in CKD has historically been placed on muscle fiber–intrinsic deficits, such as altered protein metabolism and atro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0daa5c7d500a06f4846bc81900b0c6a
https://doi.org/10.1172/jci.insight.150112
https://doi.org/10.1172/jci.insight.150112
Autor:
Sriram Gubbi, Ameya S. Kulkarni, Nir Barzilai, George A. Kuchel, Jenna M. Bartley, Jamie N. Justice
Publikováno v:
GeroScience
We are in the midst of the global pandemic. Though acute respiratory coronavirus (SARS-COV2) that leads to COVID-19 infects people of all ages, severe symptoms and mortality occur disproportionately in older adults. Geroscience interventions that tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c465db45116b6e22386f8cd85a4ba739
Autor:
Samuel T. Windham, Philip A. Kern, Marcas M. Bamman, Bailey D. Peck, Charlotte A. Peterson, Ameya S Kulkarni, Jessica C. Mar, Nir Barzilai, R. Grace Walton
Publikováno v:
Aging (Albany NY)
Evidence from clinical trials and observational studies suggests that both progressive resistance exercise training (PRT) and metformin delay a variety of age-related morbidities. Previously, we completed a clinical trial testing the effects of 14 we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5d6f63957af6d116764b8e37cca2b1b
https://pubmed.ncbi.nlm.nih.gov/33071237
https://pubmed.ncbi.nlm.nih.gov/33071237