Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ames C. Register"'
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5350 (2021)
Antibody therapeutics are expanding with promising clinical outcomes, and diverse formats of antibodies are further developed and available for patients of the most challenging disease areas. Bispecific antibodies (BsAbs) have several significant adv
Externí odkaz:
https://doaj.org/article/28c5d39819af41988dd5624d86c3949d
Autor:
Markus A. Seeliger, Ames C. Register, Sujata Chakraborty, Zachary E. Potter, Linglan Fang, Dustin J. Maly, Jessica Vilas-Boas
Publikováno v:
ACS Chem Biol
Small molecule kinase inhibitors that stabilize distinct ATP binding site conformations can differentially modulate the global conformation of Src-family kinases (SFKs). However, it is unclear which specific ATP binding site contacts are responsible
Autor:
Vilas-Boas J, Dustin J. Maly, Ames C. Register, Markus A. Seeliger, potter z, chakraborty s, Linglan Fang
Small molecule kinase inhibitors that stabilize distinct ATP-binding site conformations can differentially modulate the glob-al conformation of Src-family kinases (SFKs). However, it is unclear which specific ATP-binding site contacts are responsible
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42d8dafe0365568f5eb75b8302bed5ed
https://doi.org/10.26434/chemrxiv.12148524.v1
https://doi.org/10.26434/chemrxiv.12148524.v1
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5350, p 5350 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
Antibody therapeutics are expanding with promising clinical outcomes, and diverse formats of antibodies are further developed and available for patients of the most challenging disease areas. Bispecific antibodies (BsAbs) have several significant adv
Autor:
Guoying Jiang, Pin Yee Wong, Ho Young Lee, Ames C. Register, Edward Contreras, Khristofer Garcia, Kathleen Abadie, Qiang Wu
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
T-cell-dependent bispecific antibodies (TDBs) are promising cancer immunotherapies that recruit a patient’s T cells to kill cancer cells. There are increasing numbers of TBDs in clinical trials, demonstrating their widely recognized therapeutic pot
Publikováno v:
Biochemistry
Src-family kinases (SFKs) make up a family of nine homologous multidomain tyrosine kinases whose misregulation is responsible for human disease (cancer, diabetes, inflammation, etc.). Despite overall sequence homology and identical domain architectur
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1636
The Src family kinases (SFKs) are an important family of tyrosine kinases that are allosterically regulated by their SH2 and SH3 domains. Engagement of SFK SH2 and SH3 domains with their intramolecular ligands leads to reduced kinase activity by stab
Publikováno v:
Methods in Molecular Biology ISBN: 9781493971527
The Src family kinases (SFKs) are an important family of tyrosine kinases that are allosterically regulated by their SH2 and SH3 domains. Engagement of SFK SH2 and SH3 domains with their intramolecular ligands leads to reduced kinase activity by stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c9d6c59b90f09259a7f47011f0e7663
https://doi.org/10.1007/978-1-4939-7154-1_6
https://doi.org/10.1007/978-1-4939-7154-1_6
Autor:
Jason J. Stephany, Emily M. Dieter, Ethan Ahler, Ames C. Register, Martin Golkowski, Dustin J. Maly, Katherine A. Sitko, Rama Subba Rao Vidadala, Ethan A. Merritt, Linglan Fang, Bridget M. Trevillian, Douglas M. Fowler, Alan F. Rubin, Sujata Chakraborty, Hannah Gelman
Publikováno v:
Molecular Cell. 74:393-408.e20
Multiple layers of regulation modulate the activity and localization of protein kinases. However, many details of kinase regulation remain incompletely understood. Here, we apply saturation mutagenesis and a chemical genetic method for allosterically
Autor:
Kevin Colon-Negron, Wendy Rosenthal, Dustin J. Maly, Morvarid Mehdizadeh, Shuhei Morita, Rosa Meza-Acevedo, Jeffrey A. Bluestone, Ingeborg T. Hoffmann-Petersen, S. Armando Villalta, Hannah C. Feldman, Ames C. Register, Rajarshi Ghosh, Likun Wang, Feroz R. Papa, Bradley J. Backes
Publikováno v:
Cell Metabolism. 25:1207
In cells experiencing unrelieved endoplasmic reticulum (ER) stress, the ER transmembrane kinase/endoribonuclease (RNase)-IRE1α-endonucleolytically degrades ER-localized mRNAs to promote apoptosis. Here we find that the ABL family of tyrosine kinases