Zobrazeno 1 - 10
of 97
pro vyhledávání: '"American Association for Cancer Research"'
The consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients, Cancer Medicine 8 covers the ever-widening sphere of current cancer knowledge and clinical practic
Autor:
American Association for Cancer Research Human Epigenome Task Force, European Union, Network of Excellence, Scientific Advisory Board
Publikováno v:
Nature, vol 454, iss 7205
A plan to ‘genomicize’ epigenomics research and pave the way for breakthroughs in the prevention, diagnosis and treatment of human disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::658baf072d7e08e7363c893e62f713cc
https://escholarship.org/uc/item/09w4g15w
https://escholarship.org/uc/item/09w4g15w
Autor:
FuiBoon Kai, Guanqing Ou, Richard W Tourdot, Connor Stashko, Guido Gaietta, Mark F Swift, Niels Volkmann, Alexandra F Long, Yulong Han, Hector H Huang, Jason J Northey, Andrew M Leidal, Virgile Viasnoff, David M Bryant, Wei Guo, Arun P Wiita, Ming Guo, Sophie Dumont, Dorit Hanein, Ravi Radhakrishnan, Valerie M Weaver
Publikováno v:
The EMBO Journal. 41
Patient-derived organoids and cellular spheroids recapitulate tissue physiology with remarkable fidelity. We investigated how engagement with a reconstituted basement membrane in three dimensions (3D) supports the polarized, stress resilient tissue p
Autor:
Thompson, Emma J, Bandara, Veronika, Sadlon, Timothy, Gundsambuu, Batjargal, Tan, Lih Yin, Ricciardelli, Carmela, Barry, Simon C, Bonder, Claudine S, Annual Meeting of the American-Association-for-Cancer-Research (AACR) New Orleans, LA 8-13 April 2022
Current challenges for CAR-T therapies in solid tumors relate to target specificity and T cell penetration of the tumor. A key determinant in CAR-T selection for clinical trials is the potency and persistence of the selected CAR-T to kill cancerous c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1231::f411d71b7e9f2e68efd5bb54b4ecb151
https://hdl.handle.net/11541.2/33647
https://hdl.handle.net/11541.2/33647
Autor:
Bandara, Veronika, Mills, Stuart, Thompson, Emma, Tan, Lih, Gundsambuu, Batjargal, Napoli, Silvana, Foeng, Jade, McPeake, Dylan, Coombs, Justin, Cowin, Allison, Bonder, Claudine, Sadlon, Timothy, McColl, Shaun, Barry, Simon, Annual Meeting of the American-Association-for-Cancer-Research (AACR) New Orleans, LA 8-13 April 2022
Chimeric antigen receptor T cells (CAR-T) have demonstrated robust clinical activity against B-cell malignancies, and rapid translation to approval for use in man has inspired the search for CAR-T cells against solid tumors. Cancer stem cells are a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1231::8e53802a368eec3db3611c7912a88fd5
https://hdl.handle.net/11541.2/33648
https://hdl.handle.net/11541.2/33648
Autor:
Katrin J. Frank, Antonio Mulero-Sánchez, Alexandra Berninger, Laura Ruiz-Cañas, Astrid Bosma, Kıvanç Görgülü, Nan Wu, Kalliope N. Diakopoulos, Ezgi Kaya-Aksoy, Dietrich A. Ruess, Derya Kabacaoğlu, Fränze Schmidt, Larissa Kohlmann, Olaf van Tellingen, Bram Thijssen, Marieke van de Ven, Natalie Proost, Susanne Kossatz, Wolfgang A. Weber, Bruno Sainz, Rene Bernards, Hana Algül, Marina Lesina, Sara Mainardi
Publikováno v:
Cell Reports Medicine. 3:100815
Over 90% of pancreatic cancers present mutations in KRAS, one of the most common oncogenic drivers overall. Currently, most KRAS mutant isoforms cannot be targeted directly. Moreover, targeting single RAS downstream effectors induces adaptive resista
Autor:
Nicolas De Jay, Gustavo Turecki, Florence M.G. Cavalli, Yixing Hu, Alexis Blanchet-Cohen, Corina Nagy, W. Todd Farmer, Andréa Allaire, Hervé Sartelet, Louis Crevier, Roy W. R. Dudley, Jiannis Ragoussis, Marie Coutelier, Maxime Richer, Maria C. Vladoiu, Livia Garzia, Michael D. Taylor, Claudia L. Kleinman, Valerie Larouche, Jean Monlong, Jeffrey Atkinson, Nada Jabado, Guillaume Bourque, Laura K. Donovan, Keith K. Murai, Benjamin Ellezam, Pierre-Eric Lutz, Jean-Pierre Farmer, Brice Poreau, Leonie G. Mikael, Alexander G. Weil, Mariella G. Filbin, Steven Hébert, Selin Jessa, Santiago Costantino, Steffen Albrecht, Damien Faury, Peter B. Dirks, Brian Krug, Melissa K. McConechy
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2019, 51 (12), pp.1702-1713. ⟨10.1038/s41588-019-0531-7⟩
Nature genetics
Nature Genetics, Nature Publishing Group, 2019, 51 (12), pp.1702-1713. ⟨10.1038/s41588-019-0531-7⟩
Nature genetics
International audience; Childhood brain tumors have suspected prenatal origins. To identify vulnerable developmental states, we generated a single-cell transcriptome atlas of >65,000 cells from embryonal pons and forebrain, two major tumor locations.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d62e3aa517c3eb01edcd021b7a98be1
https://hal.archives-ouvertes.fr/hal-02437453
https://hal.archives-ouvertes.fr/hal-02437453
PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis
Autor:
Franck Tirode, Genevieve C. Kendall, James F. Amatruda, Lin Xu, Collette A LaVigne, Stephen X. Skapek, Dinesh Rakheja, Olivier Delattre, Sarah Watson, Whitney Murchison
Publikováno v:
eLife
eLife, eLife Sciences Publication, 2018, 7, ⟨10.7554/eLife.33800⟩
eLife, 2018, 7, ⟨10.7554/eLife.33800⟩
eLife, Vol 7 (2018)
eLife, eLife Sciences Publication, 2018, 7, ⟨10.7554/eLife.33800⟩
eLife, 2018, 7, ⟨10.7554/eLife.33800⟩
eLife, Vol 7 (2018)
Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused by PAX3/7-FOXO1 fusion oncogenes and is characterized by impaired skeletal muscle development. We developed human PAX3-FOXO1 -driven zebrafish models of tumorigenesis and found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad35e2bfd6d570c31060d1afafc23e0
https://www.hal.inserm.fr/inserm-02440538
https://www.hal.inserm.fr/inserm-02440538
A first-in-class CDK4 inhibitor shows excellent in vitro and in vivo efficacy against ovarian cancer
Autor:
Mekonnen, Laychiluh B, Zeleke, Solomon, Lenjisa, Jimma, Yu, Mingfeng, Noll, Benjamin, Heinemann, Gary, Milne, Robert, Albrecht, Hugo, Oehler, Martin K, Wang, Shudong, Annual Meeting of the American-Association-for-Cancer-Research (AACR) Chicago, Il 14-18 April 2018
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______1231::8288ac093c69fb3e3e74333139f248e4
https://hdl.handle.net/11541.2/137534
https://hdl.handle.net/11541.2/137534
Autor:
Emanuela Iaccarino, Gustavo Untiveros, Annamaria Sandomenico, Andrea Caporale, Luisa Calvanese, Lucia Falcigno, Gabriella D'Auria, Menotti Ruvo, Luigi Strizzi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3730::58b2ce757a3c4fc435760bc983f5cad4
http://hdl.handle.net/11588/719300
http://hdl.handle.net/11588/719300