Výsledky vyhledávání - "Amer M. Mirza"

Akademický článek

Intratumoral delivery of TransCon™ TLR7/8 Agonist promotes sustained anti-tumor activity and local immune cell activation while minimizing systemic cytokine induction

Publikováno v: Cancer Cell International, Vol 22, Iss 1, Pp 1-17 (2022)

Abstract Background Intratumoral (IT) delivery of toll-like receptor (TLR) agonists has shown encouraging anti-tumor benefit in preclinical and early clinical studies. However, IT delivery of TLR agonists may lead to rapid effusion from the tumor mic

Externí odkaz: https://doaj.org/article/9c07ff8778c14891ac4c75977cba6fba

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Quantitation of TGF-β proteins in mouse tissues shows reciprocal changes in TGF-β1 and TGF-β3 in normal vs neoplastic mammary epithelium

Autor: Amer M. Mirza, Jin-Qiu Chen, Kathleen C. Flanders, Lalage M. Wakefield, Nerissa Mendoza, Michelle A. Herrmann, Yu-an Yang

Publikováno v: Oncotarget

// Kathleen C. Flanders 1, * , Yu-an Yang 1, * , Michelle Herrmann 1 , JinQiu Chen 1 , Nerissa Mendoza 2 , Amer M. Mirza 2 , Lalage M. Wakefield 1 1 Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland, United Stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1160d38727285170b7264dd9e7e04d1
https://doi.org/10.18632/oncotarget.9416

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ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation

Autor: Baby Periyanayaki Muthusamy, Matt K. Lee, Rik Derynck, Yoko Katsuno, Amer M. Mirza, Erine H. Budi, Rosemary J. Akhurst, Susan Smith

Publikováno v: PLoS Biology, Vol 13, Iss 12, p e1002325 (2015)
PLoS Biology

Epithelial–mesenchymal transition (EMT) is a normal cell differentiation event during development and contributes pathologically to carcinoma and fibrosis progression. EMT often associates with increased transforming growth factor-β (TGF-β) signa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915c30c786a31ed735307493dfa2d7bc
http://europepmc.org/articles/PMC4682977?pdf=render

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Abstract 1768: An anti-TGF-β1/2 antibody that spares TGF-β3 retains full anti-tumor efficacy and generates an improved metabolic profile

Autor: Howard H. Yang, Maxwell P. Lee, Amer M. Mirza, Srividya Vasu, Lalage M. Wakefield, Sushil G. Rane, Yu-an Yang

Publikováno v: Cancer Research. 78:1768-1768

TGF-β family members are overexpressed in many advanced cancers and correlate with metastasis and poor prognosis. Based on encouraging preclinical data, therapeutics that target the TGF-β pathway are now in early phase clinical trials in oncology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5a6e8758d199b0187f8644d06ea962f
https://doi.org/10.1158/1538-7445.am2018-1768

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Kinetic Approach to Pathway Attenuation Using XOMA 052, a Regulatory Therapeutic Antibody That Modulates Interleukin-1β Activity

Publikováno v: Journal of Biological Chemistry. 285:20607-20614

Many therapeutic antibodies act as antagonists to competitively block cellular signaling pathways. We describe here an approach for the therapeutic use of monoclonal antibodies based on context-dependent attenuation to reduce pathologically high acti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77194264fd73d946d170c670a65fe525
https://doi.org/10.1074/jbc.m110.115790

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Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms

Autor: Toshihiko Takeuchi, Amer M. Mirza, Daniel Bedinger, Shireen Khan, Llewelyn Lao, Steve R. Lee

Publikováno v: mAbs

Transforming growth factor (TGF)β levels are elevated in, and drive the progression of, numerous disease states such as advanced metastatic cancer and systemic and ocular fibrosis. There are 3 main isoforms, TGFβ1, 2, and 3. As multiple TGFβ isofo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb135ed37f3ef0be3a4cce8f691eaf2
https://pubmed.ncbi.nlm.nih.gov/26563652

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Cooperative Regulation of the Cell Division Cycle by the Protein Kinases RAF and AKT

Autor: James M. Roberts, Martin McMahon, Keiichi I. Nakayama, Stephan Gysin, Nisar P. Malek, Amer M. Mirza

Publikováno v: Mirza, A M; Gysin, S; Malek, N; Nakayama, K; Roberts, J M; & McMahon, Martin. (2004). Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT. Molecular and Cellular Biology, 24(24), 10868-10881. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/8s19x5nb

The RAS-activated RAF-->MEK-->extracellular signal-regulated kinase (ERK) and phosphatidylinositol 3'-kinase (PI3'-kinase)-->PDK1-->AKT signaling pathways are believed to cooperate to promote the proliferation of normal cells and the aberrant prolife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f9c9bf243046cd8beea1b290c9a7aa
https://doi.org/10.1128/mcb.24.24.10868-10881.2004

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Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia

Autor: John T. Lee, Linda S. Steelman, Patrick M. Navolanic, James A. McCubrey, William L. Blalock, John G. Shelton, Richard A. Franklin, Martyn K. White, Martin McMahon, P W Moye, Amer M. Mirza

Publikováno v: Leukemia. 17:1058-1067

The Raf/MEK/ERK kinase cascade plays a critical role in transducing growth signals from activated cell surface receptors. Using DeltaMEK1:ER, a conditionally active form of MEK1 which responds to either beta-estradiol or the estrogen receptor antagon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3948fec2bc551f0c106b2b49900dd58c
https://doi.org/10.1038/sj.leu.2402925

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