Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Amer E. Villaruz"'
Autor:
Kunal Reshamwala, Gordon Y. C. Cheung, Roger C. Hsieh, Ryan Liu, Hwang-Soo Joo, Yue Zheng, Justin S. Bae, Thuan H. Nguyen, Amer E. Villaruz, Alfonso S. Gozalo, William R. Elkins, Michael Otto
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
In contrast to the virulent human skin commensal Staphylococcus aureus, which secretes a plethora of toxins, other staphylococci have much reduced virulence. In these species, commonly the only toxins are those of the phenol-soluble modulin (PSM) fam
Externí odkaz:
https://doaj.org/article/1ab25afc56a24339b5e2705178dfccee
Autor:
Fei Da, Hwang-Soo Joo, Gordon Y. C. Cheung, Amer E. Villaruz, Holger Rohde, Xiaoxing Luo, Michael Otto
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Coagulase-negative staphylococci (CoNS) are important nosocomial pathogens and the leading cause of sepsis. The second most frequently implicated species, after Staphylococcus epidermidis, is Staphylococcus haemolyticus. However, we have a significan
Externí odkaz:
https://doaj.org/article/21bfc1629fa242c88bf0174aed078fb5
Autor:
Hwang-Soo Joo, Som S. Chatterjee, Amer E. Villaruz, Seth W. Dickey, Vee Y. Tan, Yan Chen, Daniel E. Sturdevant, Stacy M. Ricklefs, Michael Otto
Publikováno v:
mBio, Vol 7, Iss 5 (2016)
ABSTRACT The virulence of many bacterial pathogens, including the important human pathogen Staphylococcus aureus, depends on the secretion of frequently large amounts of toxins. Toxin production involves the need for the bacteria to make physiologica
Externí odkaz:
https://doaj.org/article/61c33f922bf24eabbaba5dfb4d68f5fc
Autor:
Matthew W Breed, Hannah L Perez, Michael Otto, Amer E Villaruz, J Scott Weese, Gregory W Alvord, Duncan E Donohue, Franchasca Washington, Joshua A Kramer
Publikováno v:
Comparative Medicine. 73:134-144
Methicillin-resistant Staphylococcus aureus (MRSA) remains a significant problem for human and animal health and can negatively affect the health status of macaques and other nonhuman primates (NHP) in research colonies. However, few publications pro
Autor:
Yue, Zheng, Rachelle L, Hunt, Amer E, Villaruz, Emilie L, Fisher, Ryan, Liu, Qian, Liu, Gordon Y C, Cheung, Min, Li, Michael, Otto
Publikováno v:
Cell Host Microbe
Previously either regarded as insignificant or feared as potential sources of infection, the bacteria living on our skin are increasingly recognized for their role in benefitting human health. Skin commensals modulate mucosal immune defenses and dire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441b38bda487d29265e67567d362f62b
https://europepmc.org/articles/PMC8917079/
https://europepmc.org/articles/PMC8917079/
Autor:
Lei He, Gordon Y. C. Cheung, Thuan H. Nguyen, Trung V. Ho, Anthony J. Yeh, Hwang-Soo Joo, Yue Zheng, Katherine Y. Le, Emilie L. Fisher, Michael Otto, Amer E. Villaruz
Publikováno v:
Journal of Molecular Biology. 431:3015-3027
Phenol-soluble modulins (PSMs) are amphipathic, alpha-helical peptides that are secreted by staphylococci in high amounts in a quorum-sensing-controlled fashion. Studies performed predominantly in Staphylococcus aureus showed that PSMs structure biof
Autor:
Shuichi Suzuki, Saranyaraajan Varadarajan, Naoki Shimojo, Rena Oguma, Seitaro Nakagawa, Nobuko Saito, Fumiya Yamaide, Naoko Ozawa, Yasunori Sato, Masashi Akiyama, Yuumi Nakamura, Taiji Nakano, Tomoko Kobayashi, Tatsuma Shoji, Michael Otto, Yuki Katayama, Masanori Matsumoto, Hiroki Takahashi, Yuzaburo Inoue, Hiroyuki Matsue, Akiko Takaya, Michihiro Kono, Yoko Kusuya, Amer E. Villaruz, Sanami Takada, Gabriel Núñez, Eishika Dissanayake
Publikováno v:
Sci Transl Med
Atopic dermatitis (AD) is commonly associated with colonization by Staphylococcus aureus in the affected skin. To understand the role of S. aureus in the development of AD, we performed whole genome sequencing of S. aureus strains isolated from the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4261475516f86e8512d1b83bf560081b
https://europepmc.org/articles/PMC7426015/
https://europepmc.org/articles/PMC7426015/
Autor:
Thuan H. Nguyen, Gordon Y. C. Cheung, Kevin M. Rigby, Olena Kamenyeva, Juraj Kabat, Daniel E. Sturdevant, Amer E. Villaruz, Ryan Liu, Pipat Piewngam, Adeline R. Porter, Saba Firdous, Janice Chiou, Matthew D. Park, Rachelle L. Hunt, Fawaz M. F. Almufarriji, Vee Y. Tan, Titus K. Asiamah, Joshua W. McCausland, Emilie L. Fisher, Anthony J. Yeh, Justin S. Bae, Scott D. Kobayashi, Ji Ming Wang, Daniel L. Barber, Frank R. DeLeo, Michael Otto
Publikováno v:
Nature microbiology. 7(1)
Swift recruitment of phagocytic leucocytes is critical in preventing infection when bacteria breach through the protective layers of the skin. According to canonical models, this occurs via an indirect process that is initiated by contact of bacteria
Autor:
Masanori Matsumoto, Gabriel Núñez, Christiane Wolz, Amer E. Villaruz, Yuumi Nakamura, Lingzhi Zhang, Michael Otto, Seitaro Nakagawa, Naohiro Inohara
Publikováno v:
Cell Host & Microbe. 29:930-940.e4
Summary Staphylococcus aureus commonly infects the skin, but the host-pathogen interactions controlling bacterial growth remain unclear. S. aureus virulence is regulated by the Agr quorum-sensing system that controls factors including phenol-soluble
Autor:
Yanan Wang, Juanxiu Qin, Tianming Li, Min Li, Michael Otto, Qian Liu, Hwang-Soo Joo, Yan Song, Lei He, Yuanjun Zhu, Amer E. Villaruz
Publikováno v:
Infection and Immunity. 84:723-734
Staphylococcus aureus is an important human pathogen that can cause two categories of severe infections. Acute infections are characterized by pronounced toxin production, while chronic infections often involve biofilm formation. However, it is poorl