Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Amer E. Alkhalifa"'
Publikováno v:
The Breast Journal, Vol 2024 (2024)
Purpose. Breast cancer is a heterogeneous disease. Exploring new prognostic and therapeutic targets in patients with breast cancer is essential. This study investigated the expression of MET, ESR1, and ESR2 genes and their association with clinicopat
Externí odkaz:
https://doaj.org/article/00c853a6939843a8bd58d92b693bdcee
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1914 (2024)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by several pathological hallmarks, including the deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, blood–brain barrier (BBB) dysfunction, in
Externí odkaz:
https://doaj.org/article/ec31d7a17e3e459b9ccd93c983f24cb2
Autor:
Amer E. Alkhalifa, Nour F. Al-Ghraiybah, Julia Odum, John G. Shunnarah, Nataleigh Austin, Amal Kaddoumi
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16288 (2023)
The blood–brain barrier (BBB) is a unique and selective feature of the central nervous system’s vasculature. BBB dysfunction has been observed as an early sign of Alzheimer’s Disease (AD) before the onset of dementia or neurodegeneration. The i
Externí odkaz:
https://doaj.org/article/48da0cb42f784e749f57caf534e60b32
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Angiogenesis is a vital process for the growth and dissemination of solid cancers. Numerous molecular pathways are known to drive angiogenic switch in cancer cells promoting the growth of new blood vessels and increased incidence of distant metastasi
Externí odkaz:
https://doaj.org/article/6711dc9428fc4665a9c6ce82200d3f51
Autor:
Ihab M. Abdallah, Kamal M. Al-Shami, Amer E. Alkhalifa, Nour F. Al-Ghraiybah, Claudia Guillaume, Amal Kaddoumi
Publikováno v:
Molecules, Vol 28, Iss 3, p 1249 (2023)
Alzheimer’s disease (AD) is characterized by several pathological hallmarks, including the deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, blood–brain barrier (BBB) dysfunction, and neuroinflammation. Growing evidence support the
Externí odkaz:
https://doaj.org/article/32acd4122fb8431eba918d80cb3d5ce1
Autor:
Nour F. Al-Ghraiybah, Junwei Wang, Amer E. Alkhalifa, Andrew B. Roberts, Ruchika Raj, Euitaek Yang, Amal Kaddoumi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10572 (2022)
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder; it is the most common cause of dementia and has no treatment. It is characterized by two pathological hallmarks, the extracellular deposits of amyloid beta (Aβ) and the intraneu
Externí odkaz:
https://doaj.org/article/6c70caa46b644ba48f1f87120d94eb66
Publikováno v:
Investigational New Drugs. 39:77-88
MET is a receptor tyrosine kinase known to drive neoplastic transformation and aggressive tumor phenotypes. Crizotinib is an oral multi-targeted tyrosine kinase inhibitor of MET, ALK, RON, and ROS1 kinases. In this study, the anticancer effects of cr
Publikováno v:
Medical Oncology. 38
Targeted therapy is a hallmark of cancer treatment that has changed the landscape of cancer management and enabled a personalized treatment approach. Nevertheless, the development of cancer resistance is a major challenge that is currently threatenin
Publikováno v:
Breast cancer : basic and clinical research. 16
Purpose: It has been suggested that dysregulation of transcription factors expression or activity plays significant roles in breast cancer (BC) severity and poor prognosis. Therefore, our study aims to thoroughly evaluate the estrogen-related recepto
Autor:
Amer E. Alkhalifa, Rand A. Al-Waqfi, Qosay Al-Balas, Nehad M. Ayoub, Mohammad A. Hassan, Nizar A. Al-Shar’i
Publikováno v:
Journal of Computer-Aided Molecular Design. 33:799-815
The glyoxalase-I (GLO-I) enzyme, which is the initial enzyme of the glyoxalase system that is responsible for the detoxification of cytotoxic α-ketoaldehydes, such as methylglyoxal, has been approved as a valid target in cancer therapy. Overexpressi