Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amer E. Alkhalifa"'
Publikováno v:
The Breast Journal, Vol 2024 (2024)
Purpose. Breast cancer is a heterogeneous disease. Exploring new prognostic and therapeutic targets in patients with breast cancer is essential. This study investigated the expression of MET, ESR1, and ESR2 genes and their association with clinicopat
Externí odkaz:
https://doaj.org/article/00c853a6939843a8bd58d92b693bdcee
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Angiogenesis is a vital process for the growth and dissemination of solid cancers. Numerous molecular pathways are known to drive angiogenic switch in cancer cells promoting the growth of new blood vessels and increased incidence of distant metastasi
Externí odkaz:
https://doaj.org/article/6711dc9428fc4665a9c6ce82200d3f51
Autor:
Ihab M. Abdallah, Kamal M. Al-Shami, Amer E. Alkhalifa, Nour F. Al-Ghraiybah, Claudia Guillaume, Amal Kaddoumi
Publikováno v:
Molecules, Vol 28, Iss 3, p 1249 (2023)
Alzheimer’s disease (AD) is characterized by several pathological hallmarks, including the deposition of amyloid-β (Aβ) plaques, neurofibrillary tangles, blood–brain barrier (BBB) dysfunction, and neuroinflammation. Growing evidence support the
Externí odkaz:
https://doaj.org/article/32acd4122fb8431eba918d80cb3d5ce1
Publikováno v:
Breast Cancer: Basic and Clinical Research, Vol 16 (2022)
Purpose: It has been suggested that dysregulation of transcription factors expression or activity plays significant roles in breast cancer (BC) severity and poor prognosis. Therefore, our study aims to thoroughly evaluate the estrogen-related recepto
Externí odkaz:
https://doaj.org/article/285d21c1db744a0f90ebba20fb00aa71
Publikováno v:
Investigational New Drugs. 39:77-88
MET is a receptor tyrosine kinase known to drive neoplastic transformation and aggressive tumor phenotypes. Crizotinib is an oral multi-targeted tyrosine kinase inhibitor of MET, ALK, RON, and ROS1 kinases. In this study, the anticancer effects of cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f03df5bf9e483705cb5362140cf58a
https://doi.org/10.1007/s10637-020-00989-0
https://doi.org/10.1007/s10637-020-00989-0
Publikováno v:
Medical Oncology. 38
Targeted therapy is a hallmark of cancer treatment that has changed the landscape of cancer management and enabled a personalized treatment approach. Nevertheless, the development of cancer resistance is a major challenge that is currently threatenin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5090f0ec5a23fbc8a16015049dc509a6
https://doi.org/10.1007/s12032-021-01596-6
https://doi.org/10.1007/s12032-021-01596-6
Publikováno v:
Breast cancer : basic and clinical research. 16
Purpose: It has been suggested that dysregulation of transcription factors expression or activity plays significant roles in breast cancer (BC) severity and poor prognosis. Therefore, our study aims to thoroughly evaluate the estrogen-related recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a029e68613389dd705d354a4efbf0a53
https://pubmed.ncbi.nlm.nih.gov/35359609
https://pubmed.ncbi.nlm.nih.gov/35359609
Autor:
Amer E. Alkhalifa, Rand A. Al-Waqfi, Qosay Al-Balas, Nehad M. Ayoub, Mohammad A. Hassan, Nizar A. Al-Shar’i
Publikováno v:
Journal of Computer-Aided Molecular Design. 33:799-815
The glyoxalase-I (GLO-I) enzyme, which is the initial enzyme of the glyoxalase system that is responsible for the detoxification of cytotoxic α-ketoaldehydes, such as methylglyoxal, has been approved as a valid target in cancer therapy. Overexpressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e82524a70ad2279c2c8d002d432249
https://doi.org/10.1007/s10822-019-00226-8
https://doi.org/10.1007/s10822-019-00226-8
Publikováno v:
Medical oncology (Northwood, London, England). 38(1)
Hormone-dependent breast cancer is the most abundant molecular subtype of the disease. Despite the availability of endocrine treatments, the use of these drugs is limited by their serious adverse reactions and development of acquired resistance often
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3c6624f55d7367967a71b775b59caf
https://pubmed.ncbi.nlm.nih.gov/33449292
https://pubmed.ncbi.nlm.nih.gov/33449292
Publikováno v:
Clinical breast cancer. 21(4)
Breast cancer (BC) development and progression is complex and still not fully understood. The expression or dysregulation of a variety of transcription factors has been suggested as contributing to disease severity and a poor prognosis. Therefore, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b6a774a2112c68d743262bfef4be1c
https://pubmed.ncbi.nlm.nih.gov/33334698
https://pubmed.ncbi.nlm.nih.gov/33334698