Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Amer Bralic"'
Autor:
Mohamed A. Sobhy, Muhammad Tehseen, Masateru Takahashi, Amer Bralić, Alfredo De Biasio, Samir M. Hamdan
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4456-4471 (2021)
Flap endonuclease 1 (FEN1) is an important component of the intricate molecular machinery for DNA replication and repair. FEN1 is a structure-specific 5′ nuclease that cleaves nascent single-stranded 5′ flaps during the maturation of Okazaki frag
Externí odkaz:
https://doaj.org/article/66cccddbef2c4184af81169dec0324a5
Autor:
Susan E. Tsutakawa, Albino Bacolla, Panagiotis Katsonis, Amer Bralić, Samir M. Hamdan, Olivier Lichtarge, John A. Tainer, Chi-Lin Tsai
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
All tumors have DNA mutations, and a predictive understanding of those mutations could inform clinical treatments. However, 40% of the mutations are variants of unknown significance (VUS), with the challenge being to objectively predict whether a VUS
Externí odkaz:
https://doaj.org/article/ad91801f67d54b42bcc420e45cea724e
Autor:
Chi Lin Tsai, Ivaylo Ivanov, Orlando D. Schärer, Amer Bralic, Chunli Yan, Samir M. Hamdan, Susan E. Tsutakawa, John A. Tainer, Walter J. Chazin
Publikováno v:
DNA Repair (Amst)
Critical for transcription initiation and bulky lesion DNA repair, TFIIH provides an exemplary system to connect molecular mechanisms to biological outcomes due to its strong genetic links to different specific human diseases. Recent advances in stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82665d1c5f34ceff74417fbfbdf22073
https://escholarship.org/uc/item/6w3292vk
https://escholarship.org/uc/item/6w3292vk
Autor:
Samir M. Hamdan, Amer Bralic, Fahad Rashid, Vlad-Stefan Raducanu, Muhammad Tehseen, Mohamed Abdelmaboud Sobhy, Yujing Ouyang, Manal S. Zaher, Masateru Takahashi
Publikováno v:
Journal of Visualized Experiments.
Bulk methods measure the ensemble behavior of molecules, in which individual reaction rates of the underlying steps are averaged throughout the population. Single-molecule Förster resonance energy transfer (smFRET) provides a recording of the confor
Autor:
Masateru Takahashi, Samir M. Hamdan, Muhammad Tehseen, Amer Bralic, Fahad Rashid, Vlad-Stefan Raducanu, Manal S. Zaher, Mohamed Abdelmaboud Sobhy
Publikováno v:
Nucleic Acids Research
Human GEN1 is a cytosolic homologous recombination protein that resolves persisting four-way Holliday junctions (HJ) after the dissolution of the nuclear membrane. GEN1 dimerization has been suggested to play key role in the resolution of the HJ, but