Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Amer A. Rana"'
Autor:
Emma Poole, Christopher J. Z. Huang, Jessica Forbester, Miri Shnayder, Aharon Nachshon, Baraa Kweider, Anna Basaj, Daniel Smith, Sarah Elizabeth Jackson, Bin Liu, Joy Shih, Fedir N. Kiskin, K. Roche, E. Murphy, Mark R. Wills, Nicholas W. Morrell, Gordon Dougan, Noam Stern-Ginossar, Amer A. Rana, John Sinclair
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be important for HCMV latent car
Externí odkaz:
https://doaj.org/article/864ac0c6b6644a0e86c75d7df117824d
Autor:
Liam A. Hurst, Benjamin J. Dunmore, Lu Long, Alexi Crosby, Rafia Al-Lamki, John Deighton, Mark Southwood, Xudong Yang, Marko Z. Nikolic, Blanca Herrera, Gareth J. Inman, John R. Bradley, Amer A. Rana, Paul D. Upton, Nicholas W. Morrell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Reduced BMP receptor II signalling underlies pulmonary arterial hypertension (PAH). Here, Hurstet al. show that TNFα subverts BMP signalling by increasing BMP6 expression and signalling via an alternative BMP receptor, ALK2, in pulmonary artery smoo
Externí odkaz:
https://doaj.org/article/17874564742043b0848f710d036fb95a
Autor:
Kevin Yi, Sarah Eminli, Baraa Kwieder, Brad Hamilton, C-Hong Chang, Amer A. Rana, Nicholas W. Morrell, Fedir Kiskin, Jung-Il Moon, Christopher Huang
Publikováno v:
New Biotechnology. 63:1-9
The promise of using induced pluripotent stem cells (iPSCs) for cellular therapies has been hampered by the lack of easily isolatable and well characterized source cells whose genomes have undergone minimal changes during their processing. Blood-deri
Autor:
Ian J. Groves, Sarah E. Jackson, Maria Cristina Carlan da Silva, Amer A. Rana, Chris Huang, Mark R. Wills, Emma Poole, Marianne Perera, John Sinclair
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
mBio
mBio
Human cytomegalovirus (HCMV) presents a major health burden in the immunocompromised and in stem cell transplant medicine. A lack of understanding about the mechanisms of HCMV latency in undifferentiated CD34+ stem cells, and how latency is broken fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1ba662722e91e48a8a97d3c2cf134b
Autor:
Nicholas W. Morrell, Mark Southwood, Paul D. Upton, Amer A. Rana, Benjamin J. Dunmore, Stephen Moore, Christopher L.-H. Huang, Xudong Yang, Alexi Crosby, Eric D. Austin, Lu Long
Mutations in the gene encoding BMPR2 (bone morphogenetic protein type 2 receptor) are the major cause of heritable pulmonary arterial hypertension (PAH). Point mutations in the BMPR2 ligand-binding domain involving cysteine residues (such as C118W) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83be5bc57cfa8a0e7aea0cb8b5370d05
https://www.repository.cam.ac.uk/handle/1810/304151
https://www.repository.cam.ac.uk/handle/1810/304151
Autor:
Stefan Gräf, Bin Liu, J. Shih, Christopher Huang, Amer A. Rana, Nicholas W. Morrell, Marta Bleda, Matthias Haimel, Paul D. Upton
Publikováno v:
A67. STRUCTURE-FUNCTION RELATIONSHIPS.
Publikováno v:
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension ISBN: 9789811511844
Heritable pulmonary arterial hypertension belongs to a group of pulmonary vascular diseases for which there is currently no cure other than a heart and lung transplantation. Increased endothelial and smooth muscle cell proliferation leads to vascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434c3991dd6910292710a6efcf485a6d
https://doi.org/10.1007/978-981-15-1185-1_18
https://doi.org/10.1007/978-981-15-1185-1_18
Autor:
Robert Szulcek, Harm-Jan Bogaard, Iris van Zuijen, Christopher Huang, Catharina C. Wiesmeijer, Xiaoke Pan, Amer A. Rana, Maria Catalina Gomez-Puerto, Maarten van Dinther, Nicholas W. Morrell, Kondababu Kurakula, Marie-José Goumans, Peter ten Dijke
Publikováno v:
Journal of Pathology, 249(3), 356-367
Gomez-Puerto, M C, van Zuijen, I, Huang, C J Z, Szulcek, R, Pan, X, van Dinther, M A H, Kurakula, K, Wiesmeijer, C C, Goumans, M-J, Bogaard, H-J, Morrell, N W, Rana, A A & ten Dijke, P 2019, ' Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension ', Journal of Pathology, vol. 249, no. 3, pp. 356-367 . https://doi.org/10.1002/path.5322
Journal of Pathology, 249(3), 356-367. John Wiley and Sons Ltd
The Journal of Pathology
Gomez-Puerto, M C, van Zuijen, I, Huang, C J Z, Szulcek, R, Pan, X, van Dinther, M A H, Kurakula, K, Wiesmeijer, C C, Goumans, M-J, Bogaard, H-J, Morrell, N W, Rana, A A & ten Dijke, P 2019, ' Autophagy contributes to BMP type 2 receptor degradation and development of pulmonary arterial hypertension ', Journal of Pathology, vol. 249, no. 3, pp. 356-367 . https://doi.org/10.1002/path.5322
Journal of Pathology, 249(3), 356-367. John Wiley and Sons Ltd
The Journal of Pathology
Pulmonary arterial hypertension (PAH) is characterised by an increase in mean pulmonary arterial pressure which almost invariably leads to right heart failure and premature death. More than 70% of familial PAH and 20% of idiopathic PAH patients carry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec9507efe20052db98ba03322460ea3
http://hdl.handle.net/1887/120657
http://hdl.handle.net/1887/120657
Autor:
Nicholas W. Morrell, Baraa Kwieder, Sanjay Sinha, Christine Cheung, Christopher Huang, Amer A. Rana, C-Hong Chang, Felipe Serrano, Benjamin J. Dunmore, Fedir Kiskin
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 198:271-275
Supported by funding from the British Heart Foundation (BHF) (project grant PG/14/31/30786 and programme grant RG/13/4/30107), the Cambridge National Institute for Health Research Biomedical Research Centre, the Dinosaur Trust, Fondation Leducq, the
Autor:
Aharon Nachshon, Sarah E. Jackson, Christopher Huang, Noam Stern-Ginossar, John Sinclair, Fedir Kiskin, Nicholas W. Morrell, Eain A. Murphy, Bin Liu, Anna Basaj, Mark R. Wills, Amer A. Rana, Joy Shih, Gordon Dougan, Baraa Kweider, Emma Poole, Jessica L. Forbester, Dan J. Smith, Kate Roche, Miri Shnayder
Publikováno v:
Frontiers in Microbiology
Frontiers in Microbiology, Vol 10 (2019)
Frontiers in Microbiology, Vol 10 (2019)
Herpesviruses undergo life-long latent infection which can be life-threatening in the immunocompromised. Models of latency and reactivation of human cytomegalovirus (HCMV) include primary myeloid cells, cells known to be important for HCMV latent car