Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Amelie V. Guitart"'
Autor:
Simon D. J. Calaminus, Amelie V. Guitart, Amy Sinclair, Hannah Schachtner, Steve P. Watson, Tessa L. Holyoake, Kamil R. Kranc, Laura M. Machesky
Publikováno v:
PLoS ONE, Vol 8, Iss 5 (2013)
Externí odkaz:
https://doaj.org/article/7a88d4086c834ec1815637f9be24ff1f
Autor:
Kirsteen J. Campbell, Louie N. van de Lagemaat, Neil P. Rodrigues, Melania Barile, Berthold Göttgens, Arnaud Villacreces, Catarina Sepulveda, Hannah Lawson, Christopher Mapperley, Amelie V. Guitart, Suzanne Cory, Elise Georges, Joana Campos, Andrea Tavosanis, Aarushi Bellani, Lewis Allen, Catarina Martins-Costa, Kamil R. Kranc, Jozef Durko, Dónal O'Carroll
Publikováno v:
Stem Cell Reports
Summary Hematopoietic stem cells (HSCs) reside at the apex of the hematopoietic differentiation hierarchy and sustain multilineage hematopoiesis. Here, we show that the transcriptional regulator CITED2 is essential for life-long HSC maintenance. Whil
Autor:
Arnaud Villacreces, Olivier Mansier, Isabelle Vigon, Jean-Max Pasquet, Audrey Bidet, Pierre-Yves Dumas, Amelie V. Guitart, Arnaud Pigneux, Vanessa Desplat, Ali El-habhab, Solène Fernandez, Layal Massara, Delphine Martineau, Thibaut Leguay
Publikováno v:
Clinical Cancer Research
Clinical Cancer Research, American Association for Cancer Research, 2021, 27 (21), pp.6012-6025. ⟨10.1158/1078-0432.CCR-20-3114⟩
Clinical Cancer Research, 2021, 27 (21), pp.6012-6025. ⟨10.1158/1078-0432.CCR-20-3114⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, ⟨10.1158/1078-0432.CCR-20-3114⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, 27 (21), pp.6012-6025. ⟨10.1158/1078-0432.CCR-20-3114⟩
Clinical Cancer Research, 2021, 27 (21), pp.6012-6025. ⟨10.1158/1078-0432.CCR-20-3114⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, ⟨10.1158/1078-0432.CCR-20-3114⟩
Purpose: AXL has been shown to play a pivotal role in the selective response of FLT3-ITD acute myeloid leukemia (AML) cells to FLT3 tyrosine kinase inhibitors (TKI), particularly within the bone marrow microenvironment. Experimental Design: Herein, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c67dd36a63f2ce88ba9a920629e5ab
https://hal.archives-ouvertes.fr/hal-03455205
https://hal.archives-ouvertes.fr/hal-03455205
Autor:
Laura Rodriguez, Jean-Max Pasquet, Amelie V. Guitart, Pascale Duchez, Nicolas Touya, Zoran Ivanovic, Christelle Debeissat, Philippe Brunet de la Grange, Marija Vlaski-Lafarge
Publikováno v:
Biomolecules
Volume 11
Issue 4
Biomolecules, Vol 11, Iss 558, p 558 (2021)
Volume 11
Issue 4
Biomolecules, Vol 11, Iss 558, p 558 (2021)
Alpha tocopherol acetate (αTOA) is an analogue of alpha tocopherol (αTOC) that exists in the form of an injectable drug. In the context of the metabolic hypothesis of stem cells, we studied the impact of αTOA on the metabolic energetic profile and
Autor:
Jozef Durko, Andrea Tavosanis, Peter Giles, Hannah Lawson, Alena Shmakova, Nicholas M. Morton, Douglas Vernimmen, Dónal O'Carroll, Marie O'Shea, Neil P. Rodrigues, Amelie V. Guitart, Melania Barile, Andreas Lengeling, Kamil R. Kranc, Roderick N. Carter, Berthold Göttgens, Elise Georges, Milica Vukovic, Lewis Allen, Penny Timms, Catarina Sepulveda, Christopher J. Schofield, Joana Campos, Louie N. van de Lagemaat
Publikováno v:
Blood Adv
Lawson, H, Sepulveda, C, van de Lagemaat, L N, Durko, J, Barile, M, Tavosanis, A, Georges, E, Shmakova, A, Timms, P, Carter, R N, Allen, L, Campos, J, Vukovic, M, Guitart, A V, Giles, P, O'Shea, M, Vernimmen, D, Morton, N M, Rodrigues, N P, Göttgens, B, Schofield, C J, Lengeling, A, O'Carroll, D & Kranc, K R 2021, ' JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells ', Blood Advances, vol. 5, no. 3, pp. 889-899 . https://doi.org/10.1182/bloodadvances.2020002702
Lawson, H, Sepulveda, C, van de Lagemaat, L N, Durko, J, Barile, M, Tavosanis, A, Georges, E, Shmakova, A, Timms, P, Carter, R N, Allen, L, Campos, J, Vukovic, M, Guitart, A V, Giles, P, O'Shea, M, Vernimmen, D, Morton, N M, Rodrigues, N P, Göttgens, B, Schofield, C J, Lengeling, A, O'Carroll, D & Kranc, K R 2021, ' JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells ', Blood Advances, vol. 5, no. 3, pp. 889-899 . https://doi.org/10.1182/bloodadvances.2020002702
Lifelong multilineage hematopoiesis critically depends on rare hematopoietic stem cells (HSCs) that reside in the hypoxic bone marrow microenvironment. Although the role of the canonical oxygen sensor hypoxia-inducible factor prolyl hydroxylase has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9ce5b949122a2f262c58d0ad509090
Autor:
Kamil R. Kranc, Frédéric Mazurier, Amelie V. Guitart, Lewis Allen, Andrea Tavosanis, Annika Sarapuu, Milica Vukovic, Louie N. van de Lagemaat, Tim C. P. Somervaille, Gary J. Spencer, Richard I. Gregory, Jun-Ho Choe, Jasmin Paris, Douglas Vernimmen, Christopher Mapperley, Hannah Lawson, Dónal O'Carroll, Alena Shmakova, Christian Much, Joana Campos, Arnaud Villacreces, Catarina Sepulveda, Ali Anvari Azar, David Wotherspoon, Ali Nehme, Marcos Morgan, Ivayla Ivanova
Publikováno v:
Cell Stem Cell
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 25 (1), pp.137-148.e6. ⟨10.1016/j.stem.2019.03.021⟩
Paris, J, Morgan, M, Monteiro De Campos, J, Spencer, G J, Shmakova, A, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Pires Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Guitart, A, Villacreces, A, Much, C, Choe, J, Anvari Azar, A, Van De Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T C P, Gregory, R I, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m 6 A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia ', Cell Stem Cell, vol. 25, no. 1, pp. 137-148.E6 . https://doi.org/10.1016/j.stem.2019.03.021
Paris, J, Morgan, M, Campos, J, Spencer, G, Shmakova, E, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Villacreces, A, Much, C, Choe, J, Azar, A, van de Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T, Gregory, R, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia ', Cell Stem Cell, vol. 25, no. 1, e6, pp. 137-148 . https://doi.org/10.1016/j.stem.2019.03.021
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 25 (1), pp.137-148.e6. ⟨10.1016/j.stem.2019.03.021⟩
Paris, J, Morgan, M, Monteiro De Campos, J, Spencer, G J, Shmakova, A, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Pires Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Guitart, A, Villacreces, A, Much, C, Choe, J, Anvari Azar, A, Van De Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T C P, Gregory, R I, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m 6 A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia ', Cell Stem Cell, vol. 25, no. 1, pp. 137-148.E6 . https://doi.org/10.1016/j.stem.2019.03.021
Paris, J, Morgan, M, Campos, J, Spencer, G, Shmakova, E, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Villacreces, A, Much, C, Choe, J, Azar, A, van de Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T, Gregory, R, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia ', Cell Stem Cell, vol. 25, no. 1, e6, pp. 137-148 . https://doi.org/10.1016/j.stem.2019.03.021
Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation generating self-renewing leukemic stem cells (LSCs). Here we show that the mRNA m6A r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b00b59dad83bf24ff9587c68e68d11
https://hal-univ-tours.archives-ouvertes.fr/hal-02389825
https://hal-univ-tours.archives-ouvertes.fr/hal-02389825
Autor:
Badr Kilani, Olivier Mansier, Caroline Marty, Amelie V. Guitart, Alexandre Guy, Virginie Gourdou-Latyszenok, Marie Parrens, Isabelle Plo, William Vainchenker, Chloé James
Publikováno v:
Blood
Blood, American Society of Hematology, 2019, 134 (26), pp.2383-2387. ⟨10.1182/blood.2019001163⟩
Blood, American Society of Hematology, 2019, 134 (26), pp.2383-2387. ⟨10.1182/blood.2019001163⟩
The major weakness of most knock-in JAK2V617F mouse models is the presence of the JAK2 mutation in all rather than in a few hematopoietic stem cells (HSC), such as in human "early-stage" myeloproliferative neoplasms (MPN). Understanding the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3309b40fa86ef8912618a82c2a9ab7
https://hal.archives-ouvertes.fr/hal-03194452
https://hal.archives-ouvertes.fr/hal-03194452
Publikováno v:
The Journal of Experimental Medicine
The activation of Ca2+–mitochondria pathway drives cell division in hematopoietic stem cells, and the level of its activity is critical to determine cell fate after HSC division. Extracellular adenosine contributes to the regulation of Ca2+–mitoc
Autor:
Jasmin, Paris, Marcos, Morgan, Joana, Campos, Gary J, Spencer, Alena, Shmakova, Ivayla, Ivanova, Christopher, Mapperley, Hannah, Lawson, David A, Wotherspoon, Catarina, Sepulveda, Milica, Vukovic, Lewis, Allen, Annika, Sarapuu, Andrea, Tavosanis, Amelie V, Guitart, Arnaud, Villacreces, Christian, Much, Junho, Choe, Ali, Azar, Louie N, van de Lagemaat, Douglas, Vernimmen, Ali, Nehme, Frederic, Mazurier, Tim C P, Somervaille, Richard I, Gregory, Dónal, O'Carroll, Kamil R, Kranc
Publikováno v:
Cell Stem Cell
Summary Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self-renewing leukemic stem cells (LSCs). Here, we show that the
Autor:
Amelie V, Guitart, Theano I, Panagopoulou, Arnaud, Villacreces, Milica, Vukovic, Catarina, Sepulveda, Lewis, Allen, Roderick N, Carter, Louie N, van de Lagemaat, Marcos, Morgan, Peter, Giles, Zuzanna, Sas, Marta Vila, Gonzalez, Hannah, Lawson, Jasmin, Paris, Joy, Edwards-Hicks, Katrin, Schaak, Chithra, Subramani, Deniz, Gezer, Alejandro, Armesilla-Diaz, Jimi, Wills, Aaron, Easterbrook, David, Coman, Chi Wai Eric, So, Donal, O'Carroll, Douglas, Vernimmen, Neil P, Rodrigues, Patrick J, Pollard, Nicholas M, Morton, Andrew, Finch, Kamil R, Kranc
Publikováno v:
Guitart, A V, Panagopoulou, T I, Villacreces, A, Vukovic, M, Sepulveda, C, Allen, L, Carter, R N, van de Lagemaat, L N, Morgan, M, Giles, P, Sas, Z, Gonzalez, M V, Lawson, H, Paris, J, Edwards-Hicks, J, Schaak, K, Subramani, C, Gezer, D, Armesilla-Diaz, A, Wills, J, Easterbrook, A, Coman, D, So, C W E, O'Carroll, D, Vernimmen, D, Rodrigues, N P, Pollard, P J, Morton, N M, Finch, A & Kranc, K R 2017, ' Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions ', The Journal of experimental medicine, vol. 214, no. 3, pp. 719-735 . https://doi.org/10.1084/jem.20161087
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Guitart et al. performed an in vivo genetic dissection of the Krebs cycle enzyme fumarate hydratase (Fh1) in the hematopoietic system. Their investigations revealed multifaceted functions of Fh1 in the regulation of hematopoietic stem cell biology an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b414ecb67ecfd079f28382a9e58a2a5b
https://kclpure.kcl.ac.uk/en/publications/606e0f65-93b1-4f5f-9846-41292a145066
https://kclpure.kcl.ac.uk/en/publications/606e0f65-93b1-4f5f-9846-41292a145066